简介：尽管氧化是最普通生物并且精力生产反应，因为象自由激进分子和过氧化物那样的氧化的产品损坏细胞的部件，氧化应力对房间有害，引起几疾病。在DNA的损坏为癌症形成和前进负责。然而，几酶象superoxidedismutase那样，过氧化氢酶，谷胱甘肽peroxidase，谷胱甘肽reductase，是的谷胱甘肽S-transferase等等行为影响氧化应力的抗氧化剂。在这些酶的多型性应当与DNA损坏被联系，随后，个人癌症冒险危险性。这篇评论文章试图进一步阐明在由在癌症病人有关表示层次和抗氧化剂酶的基因多型性总结一些重要学习的调查结果的抗氧化剂酶和癌症之间的关系。

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简介：AbstractOxidative stress is caused by the imbalance between the generation of free radicals/reactive oxygen species (ROS) and the antioxidant defense systems, which can activate various transcription factors and affect their transcriptional pathways. Oxidative stress plays an important role in the occurrence and development of leukemia and is closely related to the treatment and prognosis of leukemia. The standard chemotherapy strategies for the pre-treatment of leukemia have many drawbacks. Hence, the usage of antioxidants and oxidants in the treatment of leukemia is being explored and has been preliminarily applied. This article reviews the research progress of oxidative stress and leukemia. In addition, the application of antioxidants treatment in leukemia has been summarized.

简介：三新diarylheptanoids，即，钠(5S,2E)-1,7-bis(4-hydroxyphenyl)-1-hydroxy-2-hepten-5-sulfonate(1)，钠(5R,2E)-1,7-bis(4-hydroxyphenyl)-1-hydroxy-2-hepten-5-sulfonate(2)和3,5-diacetoxy-1-(3-methoxy-4,5-dihydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)heptane(3)从姜officinale的根茎被孤立。新混合物的结构根据分光镜的方法被阐明。3的抗氧化剂活动在包含DPPH自由激进分子和超级氧化物阴离子激进分子的vitro模型旁边是assayed。

简介：Inordertocreateanewmimicofglutathioneperoxidase(GPx),bioimprintingwasusedtogenerategluta-thione(GSH)bindingsiteandchemicalmodificationwasusedtoincorporatecatalyticgroupselenocystine(Sec).Humanserumalbumin(HSA)andS-substituteddinitrophenylglutathione(GSH-S-DNP)werechosenastheimprintedmatrixandimprintingtemplate,respectively,togenerateaGSH-imprintedprotein(GSH-HSA)bybioimprinting.SecwasincorporatedintotheGSH-HSAbychemicalmodificationtogiveanewGPxmimic(Se-GSH-HSA).Se-GSH-HSAdisplayedconsiderablyhigherGPxactivitythannon-printedHSA(Se-HSA).TheenzymicpropertiesandkineticsofSe-GSH-HSAwerestudied.Moreover,Se-GSH-HSAwasconfirmedtohavestrongerantioxidantabilitytoprotectmitochondriaagainstoxidativedamagewithferroussulfate/ascorbate-inducedmitochondriadamagemodel,indicatingthatSe-GSH-HSAhaspotentialapplicationinmedicine.

简介：Alpiniapurpurata的目的Ethylacetate摘录在vitro抗氧化剂和anticancer活动为它的潜力被评估。抗氧化剂活动被1评估的方法，1-diphenyl-2-picrylhydrazyl(DPPH)免费激进的清除方法，氢氧根基活动，superoxide基清除活动，氮的氧化物基清除活动，氢过氧化物基清除活动和减少的力量活动。OAW42房间的生存能力被MTT试金评估。结果A。purpurata与一种集中依赖者方式展出了潜在的抗氧化剂活动。摘录与130.20g的IC50在第48小时显示出潜在的anticancer活动?潴??祥獥吗？

简介：Inordertoelucidatetheroleofantioxidantresponsesinsalinitytoleranceinricegenotypesundersaltstress,experimentswereconductedusingfourricevarieties,includingsalt-sensitiveBRRIdhan28andthreesalt-tolerantvarietiesBRRIdhan47,BINAdhan8andBINAdhan10.Thirty-day-oldriceseedlingsweretransplantedintopots.Attheactivetilleringstage(35daftertransplanting),plantswereexposedtodifferentsalinitylevels(0,20,40and60mmol/LNaCl).Saltstresscausedasignificantreductioningrowthforallthericegenotypes.Growthreductionwashigherinthesalt-sensitivegenotypethaninthesalt-tolerantones,andBINAdhan10showedhighersalttoleranceinallmeasuredphysiologicalparameters.ThereductioninshootandrootbiomasswasfoundtobeminimalinBINAdhan10.ChlorophyllcontentsignificantlydecreasedundersaltstressexceptforBINAdhan10.Prolinecontentsignificantlyincreasedinsalt-tolerantricegenotypeswithincreasedsaltconcentration,andthehighestprolinecontentwasobtainedfromBINAdhan10undersaltstress.Catalaseandascorbateperoxidaseactivitiessignificantlydecreasedinsalt-sensitivegenotypewhereassignificantlyincreasedinsalt-tolerantoneswithincreasingsaltconcentration.However,saltstresssignificantlydecreasedguaiacolperoxidaseactivityinallthericegenotypesirrespectiveofsalttolerance.K+/Na+ratioalsosignificantlydecreasedinshootsandrootsofallthericegenotypes.Thesalt-tolerantgenotypeBINAdhan10maintainedhigherlevelsofchlorophyllandprolinecontentsaswellascatalaseandascorbateperoxidaseactivitiesundersaltstress,thus,thismightbetheunderlyingmechanismforsalttolerance.

简介：一系列新与酉分的抗氧化剂消炎痛结合为提高的antiinflammatory被综合活动以及减少的ulcerogenic力量。都结合，这被发现很在vitro的有势力抗氧化剂。他们能显著地禁止类脂化合物peroxidation，当11b11e和13b13e能也与DPPH交往时。然而这些对巴豆油结合显示出的小抑制导致的老鼠耳朵胀大。

简介：超声的抽取(UE)为竹子叶多糖(BLP)的抽取被采用。包括抽取时间，超声的力量和固体/液体的比率的UE过程的有影响的参数被直角的实验优化。DEAE纤维素列层析被使用净化BLP然后BLP的激进的清除活动也被评估。最佳的抽取条件是：15min，300W的超声的力量，和1:15的固体/液体的比率的抽取时间。四种多糖被DEAE纤维素列层析获得；清除的最大的superoxide激进分子BLP的率(20.4%)低于维生素C的(VC，控制)并且清除的氢氧根激进分子率(50%)等价于VC的。

简介：Marineorganismsconstituteunlimitedresourceofbioactivesubstancesduetotheirhighbiodiversityandrepresentavaluablesourceofnewcompounds.Thisstudyoptimizedthealkali-extractionconditionsandantioxidantactivitiesofsolublepolysaccharidesfromthebodywallofSipunculusnudus.Theeffectsofsolid-liquidratio,extractionduration,extractiontemperature,andalkaliconcentrationontheyieldofS.nuduspolysaccharides(SNP)wereexamined,accordingtowhichtheoptimalcombinationofextractionparameterswasobtainedbyanorthogonaltest.TherelativeinfluencingimportanceofdifferentextractionparametersontheyieldofSNPfollowedtheorderassolid-liquidratio>extractiontemperature>alkaliconcentration>extractionduration.Thehighestextractionyield,1.98%,wasachievedunderanoptimalextractioncondition:temperature60℃,solid-liquidratio1:6gmL?1,duration5h,andalkali(NaOH)massfraction6%.TheinvitroantioxidantactivitiesexaminationshowedthatextractedSNPunderthisoptimizedconditionhadstrongpowerinreducingcertainhydroxylandsuperoxideradicalscavengingabilities.ThepromisingresultsshowedthatextractedSNPcouldbeapotentnaturalantioxidant.

简介：联系精索静脉曲张的男不孕古典主义地用外科被管理了或帮助了繁殖技术。与在联系精索静脉曲张的不孕作为一个pathophysiological因素增加氧化应力的证据，医药治疗特别抗氧化剂可能与更低的风险成为一种治疗选择。我们在归因于精索静脉曲张的男不孕的管理在各种各样的医药代理人的角色上考察了存在文学。医药治疗典型地与外科对药治疗作为辅助治疗与安慰剂，药对手术的(b)比较，和药的(c)比较处于象二药或一药的(a)比较那样的三种不同状况被评估独自一个。由于数据的异质和进行得好的研究的缺乏，有不够的数据与联系精索静脉曲张的不孕为人推荐医药治疗的平淡的使用，外科仍然是选择的处理。怀孕和实时出生率通常没在精子参数在大多数研究和仅仅的改进被报导或抗氧化剂能力是不够的支持它的平淡的使用。抗氧化剂治疗由于它的理论利益，从现出症状之前的潜的研究的数据，和主要副作用的缺乏是一种潜在的选择。有在精索静脉曲张的外科的修理以后的抗氧化剂的辅助治疗可以改进结果并且是为进一步的研究的一个潜在的区域。

简介：TheSENforthinslabcon-castingiseasytobreakanddamagebecauseoftheoxidationduringpreheatingandapplication.TheenamelcoatingmaterialisgenerallyappliedonthesurfaceofSENtoavoidtheoxidation.Thecoatingmaterialwithbornglassandsiliconasmainstartingmaterialsandsilicasolasbinderwasstudied.ZrO2-CandAl2O3-Cmaterialscontaining15%carbonwereisostaticpressed,andheatedat600℃,900℃,1200℃,1500℃for2h,respectively.Theresultsshowthatthecoatingmaterialwith70%ofboronglassand30%ofsiliconbondedbysilicasolcanformdenserprotectionlayerintheabovementionedmaterialsattherangeof600-1500℃.Theoxidationarearatioandweightlossratiowiththecoatingaremuchlowerthanthosewithoutthecoating.

简介：在聚丙烯(PP)改进硅石的分散矩阵并且避免抗氧化剂的物理损失，有表面(SG-PAMAM)上的dendricpolyamidoamines的nanosilica被使用分叉的方法综合。然后使nanosilica不能调动的抗氧化剂(SG-PAMAM-AO)被从2,6-di-tert-butyl-4-phenol(AO)被导出的grafting2,6-di-tert-butyl-4-aminophenol准备。SG-PAMAM-AO被增加进PP由融化混合学习变老的性质。PP/SG-PAMAM-AO和PP/AO混合物的氧化正式就职时间被测量。SG-PAMAM-AO的抗氧化剂性质比AO的优异，这被发现。根据在相片热的老化前后的羰基吸收的变化，PP/SG-PAMAM-AO的相片热的氧化稳定性比PP，PP/SG-PAMAM和PP/AO的高得多。

简介：BackgroundFlavonoidsfromfruits,vegetablesandplantshavebeenwidelystudiedontheireffectsofimprovinglipidemia,anti-inflammation,anti-plateletaggregationandanti-oxidativeactivities.However,wedon'tknowifflavonoidsfromrapebeepollenhavethesameeffectsinpatientswithdyslipidemia(DL),type2diabetesmellitus(T2DM),andcerebralinfarction(CI).MethodsThestudyinvolvedwithpatientsselectedanddividedinto4groups,30casesofDL,ofT2DM,ofCIandhealthcontrol(HC)foreach.Fortymgflavonoidsfromrapebeepollenadministratedorallytwiceadayfortwomonths.Bloodsugar(BG),totalcholesterol(TC),triglyceride(TG),highdensitylipoprotein-cholesterol(HDL-C),lowdensitylipoprotein-cholesterol(LDL-C),whiteblood-cellcounts(WBC),plateletcounts(PLT),high-sensitivityC-reactiveprotein(hsCRP)andmalondialdehyde(MDA)wereanalyzedinfourgroupsbeforeandaftertakingflavonoidsfortwomonths.Results(1)BasiclevelsofTC,BG,WBC,PLTandhsCRPingroupsofT2DM,CI,andTGandMDAingroupsofDL,T2DMandCIweresignificantlyhigherthanthoseinHC(P<0.05-0.001).(2)ThelevelsofTG,WBC,PLT,hsCRPandMDAweresignificantlydecreased,whileHDL-Cwasremarkablyincreasedaftertakingflavonoidsfortwomonths(P<0.05-0.001)ingroupofDL,T2MD,andCI.TheseindexeswerenotdifferentinthegroupofHCaftertakingflavonoids(P>0.05).ConclusionsTheresultscouldindicatemetabolicdisturbance,inflammation,andhighoxidativestressinpatientswithdyslipidemisa,type2diabetesmellitus,andcerebralinfarction.Theflavonoidsfromrapebeepollenmayhaveeffectsofantioxidantactivity,improvinglipids,andanti-inflammationonthesepatients.

简介：Aim:Tofindouttheeffectoflindaneontesticularantioxidantsystemandtesticularsteroidogenesisinadultmalerats.Methods:Adultmaleratswereorallyadministeredwithlindaneatadoseof5.0mg/kgbodyweightperdayfor30days.Twenty-fourhoursafterthelasttreatmenttheratswerekilledusinganestheticether.Testes,epididymis,seminalvesiclesandventralprostatewereremovedandweighed.A10%testicularhomogenatewaspreparedandcentrifugedat4°C.Thesupematantwasusedforvariousbiochemicalestimations.Results:Thebodyweightandtheweightsoftestes,epididymis,seminalvesiclesandventralprostatewerereducedinlindane-treatedrars.Therewasasignificantdeclineintheactivitiesofantioxidantenzymessuperoxidedismutase(SOD),catalaseandglutathionereductasewhileanincreaseinhydrogenperoxide(H2O2)generationwasobserved.Thespecificactivitiesoftesticularsteroidogenicenzymes3β-hydroxysteroiddehydrogenaseand17β-hydroxysteroiddehydrogenaseweredecreased.ThelevelsofDNA,RNAandproteinwerealsodecreasedinlindane-treatedrats.Conclusion:Lindaneinducesoxidativestressanddecreasesantioxidantenzymesinadultmalerats.

简介：Mercury(Hg)isoneofthecommonlyencounteredheavymetals,whichiswidespreadininshoresedimentsofChina.InordertoinvestigatethetoxicityofHgonmarineinvertebrates,westudiedtheeffectsofthedivalentmercuricion(Hg2+)(attwofinalconcentrationsof0.0025and0.0050mgL-1,preparedwithHgCl2)onmetallothionein(MT)content,DNAintegrity(DNAstrandbreaks)andcatalase(CAT)inthegillsandhepatopancreas,antioxidantenzymeactivitiesofsuperoxidedismutase(SOD),catalase(CAT)andglutathioneperoxidase(GPx),inthehemolymph,gillsandhepatopancreasoftheportunidcrabCharybdisjaponicaforanexperimentperiodupto15d.TheresultsindicatedthatMTwassignificantlyinducedafter3d,withapositivecorrelationwithHg2+doseandtimeinthehepatopancreasandanegativecorrelationwithHg2+doseandtimeinthegills.WhileCATinthehemolymphwasnotdetected,itincreasedinthehepatopancreasduringtheentireexperiment;SODandGPxinthethreetissueswerestimulatedafter12h,bothattainedpeakvalueandthenreducedduringtheexperimentalperiod.Meanwhile,DNAstrandbreakswereallinducedsignificantlyafter12h.TheseresultssuggestedthedetoxificationstrategiesagainstHg2+inthreetissuesofC.japonica.

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简介：温室实验被进行在在正常、含硒的土壤上种的二个米饭变化(PR116和PusaBasmati1121)调查硒累积和它的抗氧化剂反应。植物生长在早发展的阶段被减少，flowering被10d的一个时期在含硒的土壤上推迟。3–20和13–14增加的硒累积在叶子合拢，在从PusaBasmati1121和PR116变化的谷物的18和3褶层分别地。在从在含硒的土壤上种的大米植物的叶子的硒累积导致了叶绿素内容，氢过氧化物，脯氨酸，免费氨基酸，全部的酚和丹宁内容的重要增加。而过氧化氢酶活动显示出一个反向的趋势，在叶子的类脂化合物peroxidation层次和peroxidase活动增加了。硒累积减少了，这被结束在在庄稼期间，开发而是这些种的米饭的干燥的事内容能由在他们的防卫系统导致改变与硒毒性作斗争。

简介：Zygosaccharomycesrouxiiisasalt-tolerantyeastspeciescapableofremovingcadmium(Cd)pollutantfromaqueoussolution.Presently,thephysiologicalcharacteristicsofZ.rouxiiunderthestressofsodiumchloride(NaCl)andCdarepoorlyunderstood.ThisstudyinvestigatedtheeffectsofNaClandCdonthegrowth,oxidativestressandantioxidantenzymeactivitiesofZ.rouxiiafterstresstreatmentfor24h.ResultsshowedthatNaClorCdalonenegativelyaffectedthegrowthofZ.rouxii,butthegrowth-inhibitingeffectofCdonZ.rouxiiwasreducedinthepresenceofNaCl.FlowcytometryassayshowedthatunderCdstress,NaClsignificantlyreducedtheproductionofreactiveoxygenspecies(ROS)andcelldeathofZ.rouxiicomparedwiththoseintheabsenceofNaCl.Theactivitiesofsuperoxidedismutase(SOD),catalase(CAT),andperoxidase(POD)ofZ.rouxiiweresignificantlyenhancedby2%–6%NaCl,whichlikelycontributedtothehighsalttoleranceofZ.rouxii.ThePODactivitywasinhibitedby20mgL-1CdwhiletheSODandCATactivitieswereenhancedby8mgL-1Cdandinhibitedby20mgL-1or50mgL-1Cd.Theinhibitoryeffectofhigh-levelCdontheantioxidantenzymeactivitiesofZ.rouxiiwascounteractedbythecombineduseofNaCl,especiallyat6%.ThisprobablyaccountedforthedecreaseinCd-inducedROSproductionandcelldeathofZ.rouxiiafterincubationwithNaClandCd.OurworkprovidedphysiologicalcluesastotheuseofZ.rouxiiasabiosorbentforCdremovalfromseawaterandliquidhighlysaltyfood.