摘要
Superdisintegrantsarecross-linkedpolymersthatcanbeusedasdispersantsforfastreleaseofdrugnanoparticlesfromnanocompositemicroparticlesduringinvitroandinvivodissolution.Currentlyavailablesuperdisintegrantparticleshaveaveragesizesofapproximately5-130μm,whicharetoobigfordrugnanocompositeapplications.Hence,productionofstablesuperdisintegrantsuspensionswithlessthan5μmparticlesisdesirable.Here,weexplorethepreparationofcolloidalsuspensionsofanionicandnonionicsuperdisintegrantsusingawetstirredmediamillandassesstheirphysicalstability.Sodiumstarchglycolate(SSG)andcrospovidone(CP)wereselectedasrepresentativeanionicandnonionicsuperdisintegrants,andhydroxypropylcellulose(HPC)andsodiumdodecylsulfate(SDS)wereusedasastericstabilizerandawettingagent/stabilizer,respectively.Particlesizing,scanningelectronmicroscopy,andzetapotentialmeasurementswereusedtocharacterizethesuspensions.Colloidalsuperdisintegrantsuspensionswerepreparedreproducibly.Theextensiveparticlebreakagewasattributedtotheswelling-inducedsofteninginwater.SSGsuspensionswerestableevenintheabsenceofstabilizers,whereasCPsuspensionsrequiredHPC-SDSforminimizingparticleaggregation.Thesefindingswereexplainedbythehigherabsolute(negative)zetapotentialofthesuspensionsoftheanionicsuperdisintegrant(SSG)ascomparedwiththoseofthenonionicsuperdisintegrant(CP).
出版日期
2014年03月13日（中国期刊网平台首次上网日期，不代表论文的发表时间）
