摘要
Objective:ToevaluatetherelationshipbetweentheefficienciesofsubsegmentalTAEandtheexpressionofPCNAwithABCimmunohistochemicalstaininginHCCs.Methods:Ultrasound-guidedneedlebiopsieswereperformedin43patients(41men,2women;agerange:32～75years,mean,55.6years).PCNAwereexaminedusingABCimmunohistochemicalstaining.TumorscoresofPCNAwereassessedbycountingthepositivenucleiper1,000cells.AllthecasesreceivedsubsegmentalTAEwithiodizedoilandgelatinsponge.AcorrelationbetweentheexpressionofPCNAandtheefficienciesofsubsegmentalTAEwassought.Normalitytest,ranksumtestandChi-squaretestwereusedinstatisticalanalyseswithSASpackage.Results:ThemeanPCNAlabelingindexwas58±29(range,27-100%)in43patients.Whencomparedwiththemacroscopicandpathologicparameters,PCNAlabelingindexwasfoundtobesignificantlyrelatedtothepresenceandactivityofcirrhosis.PCNAlabelingindexdidnotrelatedtopatients'age,sex,HbsAgstatusorserumα-fetoproteinlevel.ThePCNAlabelingindexcorrespondedtothedegreeofhistologicaldifferentiation(Edmenderson-Steinergrading).ThesurvivalratesaftersubsegmentalTAEwererespectively86.05%,65.12%and51.16%inone-,two-andthree-years,andweresignificantlyhigherinthelowlabelingindexgroupthanthatinthehighlabelingindexgroup.Conclusion:ThePCNAlabelingindexwasshowntobecloselyrelatedtohistologicalcharacteristicsandsurvivalofthepatients.
出版日期
2004年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
