Study on the value of exogenous bFGF in the treatment of brain injury-中国期刊网

摘要 Objective:ToinvestigatetherelationbetweennecrosisandapoptosisinthehippocampusofexogenousbFGFonthisprocess.Methos:WithMarmarou'smethodweproducedaseverediffusebraininjuryandstudiedthechangesinthehippocampusbyadaptingamodifiedTdT-mediateddUTP-biotinnickendlabeling(TUNEL)method.AtthesametimeweobservedtheeffectofexogenousbFGFonneuronalnecrosisandapoptosis.Results:WefoundthattogetherwithcellnecrosistherewasanincreaseinthenumberofapoptoticneuronsinthehippocampusCA2-3sectorsasearlyas4hafterinjury,withnumbersreachingamaximumat7d.ExogenousbFGFresultedinadefinitereductionintheamountofnecrosisandapoptosis.Conclusions:NeuronalnecrosisandapoptosisoccurincombinationafterbraininjuryandthatoneofthecausesmaybetheinsufficienceexpressionofthebFGFgeneinthehippocampusaftersevereinjury.ExogenousbFGFandsimilarsubstancemayproveclinicallyusefulafterbraininjurybyreducingcellnecrosisandapoptosis.

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Study on the value of exogenous bFGF in the treatment of brain injury

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Study on the value of exogenous bFGF in the treatment of brain injury

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