Acoustic trauma-induced auditory cortex enhancement and tinnitus-中国期刊网

摘要 Thereisgrowingevidencesuggeststhatnoise-inducedcochleardamagemayleadtohyperexcitabilityinthecentralauditorysystem(CAS)whichmaygiverisetotinnitus.However,thecorrelationbetweentheonsetoftheneurophysiologicalchangesintheCASandtheonsetoftinnitushasnotbeenwellstudied.Toinvestigatethisrelationship,chronicelectrodeswereimplantedintotheauditorycortex(AC)andsoundevokedactivitiesweremeasuredfromawakeratsbeforeandafternoiseexposure.Theauditorybrainstemresponse(ABR)wasusedtoassessthedegreeofnoise-inducedhearingloss.Tinnituswasevaluatedbymeasuringgap-inducedprepulseinhibition(gap-PPI).Ratswereexposedmonaurallytoahigh-intensitynarrowbandnoisecenteredat12kHzatalevelof120dBSPLfor1h.Afterthenoiseexposure,alltheratsdevelopedeitherpermanent(>2weeks)ortemporary(<3days)hearinglossintheexposedear(s).TheACamplitudesincreasedsignificantly4hafterthenoiseexposure.Mostoftheexposedratsalsoshoweddecreasedgap-PPI.Thepost-exposureACenhancementshowedapositivecorrelationwiththeamountofhearingloss.Theonsetoftinnitus-likebehaviorwashappenedaftertheonsetofACenhancement.

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Acoustic trauma-induced auditory cortex enhancement and tinnitus

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Acoustic trauma-induced auditory cortex enhancement and tinnitus

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