摘要
Aim:Todetermineifandrogensdirectlyregulateveno-occlusionorifandrogensactindirectlytomaintainthepenilestrutureswhichcontroloutflow.Methods:UsingCASTRATEandTESTOrots,measurementwasmadeofmeanarterialpressure(MAP),intracavemosalpressure(CCP),andintracavemosalflow(CCF)duringerectionresultingfromstimulationoftheautonomicinnervationofthepenis.CCPandCCFwerealsomeasuredduringsalineinfusionintothecavemosalsinusesbeforeandaftertreatmentwithsodiumnitropmsside(SNP,anitricoxidedonordrug)tofullyrelaxcavemosalsmoothmuscle.Peniletissuewasalsocollectedtomeasurethecontentofaactinandproliueandhydroxyprolinetodetermineifbriefwithdrawalofandrogenicsupportledtochangesinthenumberofsmoothmusclecellsorthecollagencontentofthetissue.Resttlts:Infusionofsalineintothecavemosalsinusesdemonstratedthatveno-occlusionwasdefectiveinCASTRATEratswhileveno-occlusionwasfullyfunctionalinTESTOanimals.Funtmmore,veno-occlusioncouldbeinducedinCASTRATEratsiftheywerefirstnearedwithSNP.Thisobservationsuggeststhatfailureofveno-occlusionintheCASTRATEratsisduetoadeficiencyintheproductionofNOresultinginareductioninthedegreeofrelaxationofthepenilesmoothmuscle.Themeasurementsofsmoothmuscleaactinandprolineandhydroxyprolinecontentofcollagenshowedthatbothwereunaffectedbycastrationandthatthebasicstructureofthepenisdidnotdegenerateafteroneweekwithoutandrogenicsupport.Conclusion:Theseresultscanbeinteipretedtomeanthatandrogenscontroltheveno-occlusivemechanismindirectlyviaaNOdependentmechanismandnotbymaintainingthestructuresofthepeniswhichareessentialtoveno-ocelusion.(AsianJAndrol1999Jun;1:53-59)
出版日期
1999年01月11日（中国期刊网平台首次上网日期，不代表论文的发表时间）
