摘要
摘要目的研究多发性硬化(MS)患者抑郁的发生率及相关因素.方法应用汉密尔顿抑郁量表(HAMD)对４５例MS患者和４０名健康体检者进行抑郁评定,以及对MS患者进行日常生活能力量表(ADL)评分,匹兹堡睡眠质量指数量表(PSQI)评分.结果４５例MS患者１８例(４０．０％)伴发抑郁,其中轻度抑郁１２例(２６．７％),中度抑郁５例(１１．１％),重度抑郁１例(２．２％);４０例对照组中５例(１２．５％)伴发抑郁,其中轻度４例(１０％),中度抑郁１例(２．５％).两组相比较差异有统计学意义.(X２＝２１．４５８,１１．０４５,４．８９,P＜０．０１).MS患者抑郁组与非抑郁组PSQI总分及各因子比较显示PSQI总分、主观睡眠质量(F１)、入睡时间(F２)、睡眠干扰(F５)差异有统计学意义.抑郁与MS患者ADL评分,睡眠质量,左侧大脑半球病灶,性别相关,(P＜０．０１).结论MS患者有较高的抑郁发生率,抑郁的程度与ADL评分,睡眠质量,幕上病灶数,性别相关.关键词多发性硬化;抑郁;日常生活能力评分AbstractObjectiveTostudytheincidenceandrelatedfactorsofMultiplesclerosis(MS)patientswithdepression,．Methods４５Multiplesclerosis(MS)p(atientsand４０healthysubjectswereassessedwithHamiltonDepressionScale(HAMD),aswellasMSpatientswereassessedwithactivitiesofdailylivingADL)scoreandPittsburghSleepQualityIndexScale(PSQI)score．ResultsOf４５Multiplesclerosispatients,１８cases(４０．０％)wereComplicatedbydepresＧsion．１２cases(２６．７％)milddepression,５cases(１１．１％)moderatedepression,onecase(２．２％)severedepression．Of４０casesinthecontrolgroup,５cases(１２．５％)wereComplicatedbydepression．４cases(１０％)milddepression,onecase(２．５％)moderatedepression．Thereweresignificantstatisticallydifferentbetweentwogroups(X２＝２１．４５８,１１．０４５,４．８９,P＜０．０１).DifferentenceofPSQIscores,subjectivesleepquality(F１),sleeptime(F２),sleepdisturbances(F５)betweendepressiongroupandnon－depressiongroupwerestatisticallysignificant．MSpatientswithdepressionwererelatedwithADLscore,qualityofsleep,theleftcerＧebralhemispherelesionsandgenderofpatients(P＜０．０１)．ConclusionsMSpatientshaveahigherincidenceofdepression;MSpatientswithdepressionwerereＧlatedwKietyhAwoDrLdsscores,qualityofsleep,numberoflesionsonthescreen,andgender．Multiplesclerosisdepressionactivitiesofdailyliving(ADL)score中图分类号R７４４．５文献标识码B文章编号１００８－６３１５(２０１５)１２－００９４－０２
出版日期
2015年12月22日（中国期刊网平台首次上网日期，不代表论文的发表时间）
