替吉奥单药治疗初治老年晚期胃癌的临床观察

替吉奥 晚期胃癌 临床疗效 毒副反应 Abstract Objective To study the efficacy and toxicity of S-1 alone in the treatment of untreated patients with advanced gastric cancer. Methods From Jan 2012 to Jun 2014 34 untreated patients with advanced gastric cancer were enrolled for this study. All patients underwent chemotherapy with S-1 single regimen. Results All 34 patients received at least two cycles of chemotherapy with S-1 single regimen. The median survival time was 8.2 months and the clinical benefite rate was 47%. The main adverse events were myelosuppression and gastrointestinal disorders. Conclusion S-1 single regimen in the treatment of untreated patients with advanced gastric cancer is effective and the toxicities are tolerable and improve patient's life quality. It deserves further clinical applications. Key Words S-1 Advanced gastric cancer Clinical efficacy Toxicity