微颗粒在脓毒症中的作用

微颗粒 不同细胞来源 脓毒症 病理生理作用中图分类号R2 文献标号A 文章编号2095-7165（2015）10-0042-02Role Of Microparticles In SepsisYelijun Dengliehua（Department of Critical Care Medicine Affiliated Hospital of Guangdong Medical College Zhanjiang China 524001）abstractMicroparticles are plasma membrane vesicles releasing from various cell types which are stilling activation or apoptosis and they are measuredfrom 0.2 &mu m to 2 &mu m. Recently researches focus on the study of microparticles released from platelet endothelium and leucocyte and there are studiesshown that those microparticles are playing an important role in immune adjustment promoting coagulation induction of endothelial dysfunction.Haemostatic imbalance leads to various pathological states of inflammation and thrombosis including cardiovascular disease and sepsis where circulatingmicroparticles display both an increase in number and phenotypic change mainly of platelet origin microparticles enable both local and disseminated amplificationof the haemostatic