摘要
Aseriesofcross-linkedhydrogelsforcolon-specificdrugdeliveryweresynthesizedbygraftcopolymerizationofChitosanandacrylicacidusingN,N'-methylene-bis-(acrylamide)asacross-linker.TheirswellingbehaviorindifferentpHbuffersolutionsandcolonicenzymaticdegradabilitywerestudied.TheobtainedresultsshowthatthesehydrogelshavegoodpHsensitivitywhichcanavoiddrugreleaseinstomach,andtheirswellingkineticsinstimulantintestinalenvironmentfollowsecond-orderswellingkineticsequation.Thefactorsinfluencingtheswellingkineticsincludethedegreeofcross-linkingandthecomposition,whichmaycontrolnoreleaseoralittleamountreleaseofdruginsidethehydrogelsinthesmallintestinebytailoringthesefactors.Thegelsaredegradablebycolonicenzymesandthereisacorrelativitybetweenthedegradationofnetworksandtheswellingdegreeofthegels,whichmaytriggerthereleaseofdruginthecolon.Thehydrogelsshowagreatpotentialfortheirapplicationinoralcolon-specificdrugdeliverysystem.
出版日期
2010年02月12日(中国期刊网平台首次上网日期,不代表论文的发表时间)