简介：乙醇2-的催化不对称的加氢的申请(benzo[b]thiophen-5-yl)为认知enhancerT-588的正式合成的-2-oxoacetate被描述。加氢作为添加剂与HCl在Ru-SunPhos系统的催化作用下面被进行。乙醇2-(benzo[b]thiophen-5-yl)-2-hydroxy-acetate与98.6%ee被获得，它能容易在简单再结晶以后被升级到99.5%ee并且在T-588的合成用作关键中介。
Catalytic Asymmetric Hydrogenation of Ethyl 2-（Benzo[b]thiophen-5-yl）-2-oxoacetate with Ru-SunPhos in the Formal Synthesis of T-588
![Catalytic Asymmetric Hydrogenation of Ethyl 2-（Benzo[<b style='color:red'>b</b>]thiophen-5-yl）-2-oxoacetate with Ru-SunPhos in the Formal Synthesis of T-588](/image/thesis0 "Catalytic Asymmetric Hydrogenation of Ethyl 2-（Benzo[<b style='color:red'>b</b>]thiophen-5-yl）-2-oxoacetate with Ru-SunPhos in the Formal Synthesis of T-588")