学科分类
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1 个结果
  • 简介:Ionchannelsareessentialforcellularsignaling.Voltage-gatedionchannels(VGICs)arethelargestandmostextensivelystudiedsuperfamilyofionchannels.Theypossessmodularstructuralfeaturessuchasvoltage-sensingdomainsthatencircleandformmechanicalconnectionswiththepore-formingdomains.Suchfeaturesareintimatelyrelatedtotheirfunctioninsensingandrespondingtochangesinthemembranepotential.Inthepresentwork,wediscussthethermodynamicmechanismsoftheVGICsuperfamily,includingthetwo-stategatingmechanism,sliding-rockingmechanismofthevoltagesensor,subunitcooperation,lipid-infiltrationmechanismofinactivation,andtherelationshipwiththeirstructuralfeatures.

  • 标签: Ion channel GATING mechanism MEMBRANE potential