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简介：　　ThemissionoftheChemicalProcessR&DDepartmentatDuPontPharmaceuticalsCompanyistosupplydrugsubstanceinatimelyfashionandtodiscover/developascalable,economical,environmentallyfriendlyprocessforthecommercialproductionofthebulkdrugsubstance.Severalexampleswillbepresentedtoillustrateourefforttoaccomplishthemission.Briefdiscussionwillincludethefollowingprojects:1)SynthesisofDMP728,acyclicpeptideofGPIIb/IIIainhibitor2)Methodforthepreparationofa-chloroboronicacid,akeyintermediateforDuP714,apotentthrombininhibitor3)ProcessresearchanddevelopmentofRoxifiban,apotentandorallyactiveGPIIb/Illainhibitor　　……
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Development of a Two-photon Ratiometric Fluorescent Probe for Glutathione and Its Applications in Living Cells

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