简介:Anewcaseofepithelioidhemangioendotheliomaisreportedtohaveoccurredtoa67-year-oldpatientwhoconsultedforrightsidedchestpain.Thework-upshowedmultiplerightpulmonarylesionsassociatedwithbilateralmoderatepleuraleffusionandleft-sidedpleuralthickeningandthreehypodensenodulesintherightlobeoftheliver,peritonealthickening,ascites,andmultiplevertebrallyticlesions.Thediagnosisofanepithelioidhemangioendotheliomawasconcludedthroughahistologicalexaminationofacomputedtomographyscanguidedbiopsyoftheliver.Thepatientreceivedaprimarymono-chemotherapywithAdriamycin(75mg/m~2everythreeweeks)andintravenousbisphosphonateswithoutresponseandgeneralstatusimpairment.Thepatientdiedafter16monthsoffollow-up.
简介:Sarcoidosisisabenignsystematicgranulomatousdisorderofunknownetiologyandisassociatedwithvariousmalignancies.However,granulomatousandmetastaticlymphnodelesionsaredifficulttodistinguishevenwhenusingpreciseandmoderndiagnosticmethods,suchaspositronemissiontomography.Thus,histologicalverificationistheonlymethodthatcanbeusedtoaccuratelydescribethenatureofthisdisease.Inthisarticle,wereportacaseofnon-luminalHER-2/neu-positivebreastcancerinapatientwithouthistoryofsarcoidosisandsuspectedtohavemetastaticdisease.
简介:Autoimmunehepatitis(AIH)hasrarelybeendescribedasanautoimmuneparaneoplasticsyndromeofthymoma.ThiscaseistheseventhcaseofAIHrevealedbycholestasisfewyearsafterthediagnosisofthymomaandthefirstcasetreatedwithchemotherapyalone.Wereportinthispaperanewapproachtothisrareseverecondition.A29year-oldmanpresentedwithchestpainanddyspneawithahistoryofthymomasurgicallyremoved4yearsago.CTscanshowedtherecurrenceofananteriormediastinalmass.Biologyshowedelevatedliverenzymesandprofoundcholestasis.Nosignofviralortoxichepatitisorbileductabnormalitieswereobserved.Autoimmuneantibodies,exceptfortheanti-nuclearantibody,werenegative.LiverbiopsyshowedactivechronicAIH.ThepatientwasdiagnosedwithrecurrentthymomawithAIHandunderwent6cyclesofchemotherapy.Acompleteresponseonthymomaandcholestasiswasobtainedafter10monthsoffollow-up.SteroidsandimmunosuppressorsarethestandardtreatmentforAIH.Theeffectofchemotherapyasaspecifictreatmentofthisparaneoplasticsyndromeneedstobeconsidered.
简介:Breastmetastasisfromextra-mammarymalignancyisrare.Anincidenceof0.4%to1.3%hasbeenreportedinliterature.Theprimarymalignanciesthatmostcommonlymetastasizetothebreastareleukemia,lymphoma,andmalignantmelanoma.Inthisreport,twocasesofpulmonarymetastasistothebreastwerepresented.A40-year-oldfemalemanifestedarightbreastmassof2-monthduration.Afterphysicalexaminationwasperformed,apoorlydefinedmasswasnotedintheupperouterquadrantoftherightbreast.Another49-year-oldfemalemanifestedrightbreastmassof5-dayduration.Apoorlydefinedmasswasnotedinthelowerinnerquadrantoftherightbreast.Mammographyresultsalsorevealedbreastcancer.Thepatientsunderwentlocalexcision.Afterhistologicalandimmunohistochemicalanalyseswereconducted,aprimarylungcarcinomathatmetastasizedtothebreastwasdiagnosed.Anaccuratedifferentiationofmetastasistothebreastfromprimarybreastcancerisveryimportantbecausethetreatmentandprognosisofthetwodiffersignificantly.
简介:Extrapulmonarysmallcellcarcinoma(EPSCC)isarareneoplasmcomprising2.5%to5%ofsmallcellcarcinomas(SCCs).BladderSCCisthemostcommonsiteofgenitourinarytract.PrimaryrenalSCCisextremelyrare.WereportacaseofprimarySCCofthekidneywhichisrarelyreportedintheurinarytractandpresentsanaggressiveclinicalpicture.A59-year-oldfemalevisitedaurologicclinicwithcomplaintofpersistentleftflanksoreness10yearsafterundergoingrenaltransplantation.Abdominalcomputedtomographyshowedaleftrenalpelvistumor.Afterthepatientreceivedleftnephroureterectomywithbladdercuffresection,herpathologyresultsshowedSCC.Aftersurgery,shereceivedadjuvantsystemicchemotherapy,andherrecoveryhasbeenuneventfulasof8months.PrimaryrenalSCCpresentswithanadvancedtumorstageandashortmediansurvivalperiod,thereforeearlyinterventionandclosefollow-uparerecommended.
简介:Renalcellcarcinoma(RCC)accountsforapproximately3%ofallcancercases.RCCsusuallymetastasizetothelungs,bones,liver,orbrain.Only<1%ofpatientswithbonemetastasesmanifestedclavicularRCCmetastases.Thus,clavicularmetastasisastheinitialpresentationofRCCisextremelyrare.WereportapatientwithRCCmetastasistotheleftclavicle,whichwasfirstpresentedwithpaincausedbyapathologicalfracture.Magneticresonanceimagerevealedarenaltumor,andtechnetium-99m–methylenediphosphonatebonescintigraphyshowedmultipleosseousmetastases.Thepatienteventuallyunderwentsurgerytoremovethelateralendoftheleftclavicleandrightkidney.Histopathologyrevealedrenaltumorandclearcellcarcinomaintheclavicle.Finally,wereview17casesofclavicularmetastasesoriginatingfromdifferentmalignancies.
简介:Lymphomararelyoccursduringpregnancy,makingthisconditiondifficulttodefine.Lymphomasthatoccurinreproductiveorgansduringpregnancyexhibituniqueclinicalcharacteristics.Amongthelimitedcases,non-Hodgkin'slymphoma(NHL)showsaconsiderablyhigherincidenceratethanHodgkin'slymphoma(HL);NHLalsodisplaysclinicalcharacteristics,suchashighaggressiveness,advancedstage,andpooroutcome.Thisstudyreportsonfourcasesoflymphomasinnon-gonadalorgans(HL,n=2;NHL,n=2)duringpregnancy.Thetumorsrapidlyprogressedinallpatientsduringpregnancybutremittedattheendofpregnancyand/ortherapy.ThetwoHLcaseswerenodularsclerosisclassicalHLandtreatedwithchemotherapyafterterminatingthepregnancy.OneoftheNHLcaseswasprimarycutaneousfollicularcenterlymphoma,aBcell-derivedindolentlymphoma.Thepatientwasfollowedupwithoutanytherapyafterterminatingherpregnancy.Theothercasewasafollicularlymphomagrade3B,whichwastreatedwithchemotherapyafterdelivery.Wealsoconductedaliteraturereviewof165lymphomacasesoccurringduringpregnancyreportedfrom1976to2013torevealthecorrelationbetweenpregnancyandlymphomaprogression.Immunohistochemistrystudieswereperformedtodeterminetheexpressionofestrogen/progesteronereceptors(ER/PR),andERwasweaklypositiveandsporadic.Weconcludedthatlymphomasoccurringduringpregnancyshouldbemanagedwithapromptandreasonabletreatment.Highestrogenlevelinmaternalbodymayaffectlymphomaprogression.
简介:Surgeryfollowingneoadjuvantchemoradiotherapy(NCRT)isacommonmultidisciplinarytreatmentforresectableesophagealcancer(EC).Afteranalyzing12randomizedcontrolledtrials(RCTs),wediscussthekeyissuesofsurgeryinthemanagementofresectableEC.Alongwithchemoradiotherapy,NCRTisrecommendedforpatientswithsquamouscellcarcinoma(SCC)andadenocarcinoma(AC),andmostchemotherapyregimensarebasedoncisplatin,fluorouracil(FU),orboth(CF).However,taxane-basedschedulesoradditionalstudies,togetherwithnewerchemotherapies,arewarranted.Innineclinicaltrials,post-operativecomplicationsweresimilarwithoutsignificantdifferencesbetweentwotreatmentgroups.In-hospitalmortalitywassignificantlydifferentinonly1outof10trials.HalfoftherandomizedtrialsthatcompareNCRTwithsurgeryinECdemonstrateanincreaseinoverallsurvivalordisease-freesurvival.NCRToffersagreatopportunityformarginnegativeresection,decreaseddiseasestage,andimprovedloco-regionalcontrol.However,NCRTdoesnotaffectthequalityoflifewhencombinedwithesophagectomy.Futuretrialsshouldfocusontheidentificationofoptimumregimensandselectionofpatientswhoaremostlikelytobenefitfromspecifictreatmentoptions.
简介:DearFriendsandColleaguesOnbehalfoftheorganiingCommittee,wearepleasedtowelcomeyoutoparticipateinthe2~(nd)InternationalSymposiumonTranslationalCancerResearchtobeheldonAugust18~(th)-20(th),2016inTianjin,China.In2002,TianjinMedicalUniversityCancerInstituteandHospital,togetherwithTheUniversityof
简介:Molecularsubtypingofbreastcancermayprovideadditionalprognosticinformationregardingpatientoutcome.Theepidermalgrowthfactorreceptor(HER2)overexpressingbreastcancersaredesignatedasHER2-postive(HER2+)breastcancerandcarryaparticularlyunfavorableprognosis.WepresenttwocasesofHER2-postivemetastaticbreastcancer(MBC)whoarefoundtobeachallengetotreat,especiallyduetotheoccurrenceofbrainmetastasis.Trastuzumab-basedtherapyimprovesclinicaloutcomes,evenifthepatienthasundergonemulti-linetreatment.ThesecasereportsalsoemphasizetheimportanceofretestingHER2statusbecauseitcanbediscordanceinreceptorstatusbetweenprimaryandrecurrentbreastcancer.
简介:Objective:Toassesstheimpactofpastlivermetastasesonthesurvivaldurationofpatientswhoareundergoingsurgeryforlungmetastases.Methods:Weconductedareviewofliteraturepublishedfrom2007to2014.ThestudieswereidentifiedbysearchingPubMed,MEDLINE,andEmbaseandweresupplementedbyamanualsearchofthereferenceslistedbytheretrievedstudies.Thefollowingsearchtermswereused:lungmetastasectomy,pulmonarymetastasectomy,lungmetastases,andlungmetastasis.Weselectedretrospectiveandprospectivestudiespublishedfrom2007to2014onpatientswithlungmetastasesfromcolorectalcancerandwereundergoingsurgerywithcurativeintent.Weexcludedreviews,studiesthatfocusedonsurgicaltechniques,patientswhoweretreatednon-surgically,analysesofspecificsubgroupsofpatients,andthosethatdidnotreportfollow-upofthepatientsundergoingsurgery.Results:Weidentified28papersthatassessedsurvivalafterlungmetastases,21ofwhichweremostlyretrospectivestudiesthatidentifiedpreviouslivermetastasestoexploretheirimpactonpatientsurvival.Inmorethanhalfofthepapersanalyzed(63.2%),patientswithahistoryofresectedlivermetastaseshadalowersurvivalratethanthosewhodidnothavesuchahistory,andthedifferencewasstatisticallysignificantineightofthesestudies.However,datawerepresenteddifferently,andauthorsreportedmeansurvivaltime,survivalrates,orhazardratios.Conclusions:Ahistoryoflivermetastasesseemstobeanegativeprognosticfactor,buttheindividualdataneedtoundergoameta-analysis.
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简介:Aseventyeightyearsoldmalepatientunderwentawholebody18F-FDGPET/CTimagingtodiagnosethelesionwhichwasshowedintherightlungbyachestXraytestandCTscanbefore.Besidestheintense18F-FDGuptakeofthelesionintherightlung,alesionintheleftparotidglandalsoshowedintense18F-FDGuptake.Toevaluatethepathologyofthelesionintheleftparotidgland,aparotidglandscintigraphyimagingwithTc-99mpertechnetatewasdoneandrevealedaWarthin'stumor.Laterafineneedleaspiration(FNA)confirmedthatitwasaWarthin'stumor.