简介：Eatmore‘green’oreat‘fiveaday’isoneofthemostimportanthealthylifestylebehavioursinthe21century.Aimingtofightcancereffectively,morethanhalfpatientsusevitaminsorherbsconcurrentlywithconventionalanticancertreatment.Flavonoidsorpolyphenolsexistinginvegetables,fruitsandgreenteaarecommonplantpigmentswithantioxidantpropertiesandconsideredactingascancerpreventingoranti-canceragents.RecentlyitwasfoundthatsomeflavonoidsandvitaminCindietorsupplementshaveantagonisticeffectwiththeanti-cancerdrugbortezomib.Bortezomibisaspecificinhibitorforproteasomeandiscurrentlyusedfortreatmentofrelapsedandrefractorymultiplemyeloma.Despiteitssuccessfulratesintreatingmultiplemyelomaandothersolidtumors,itisunabletokillleukemiccellsintheblood.ItwasrecentlyrevealedthatsomeflavonoidsandvitaminCpresentingreenleavesandgreenteasinthebloodcanneutralizebortezomibbydirectlyinteractionbetweentwochemicals.Herewesummarizewhydietaryflavonoidsshouldbeavoidedinpatientswhotakebortezomibaschemotherapeuticdrug.

简介：Objective:Thisrandomizedstudyaimedtocomparetheclinicalefficacybetweenthenoveldualtracercomposedofindocyaninegreen(ICG)andbluedye(BD)andtheconventionaldualtracercomposedofradioisotopeandBDforsentinellymphnode(SLN)mappinginpatientswithbreastcancer.Methods:Thisstudyenrolled471clinicallylymphnode-negativepatientswithprimarybreastcancer.Allpatientsunderwentmastectomy,andthoseundergoingsentinellymphnodebiopsy(SLNB)wererandomizedtoreceivebluedyeplusradioisotope(RBgroup)orBDplusICG(IBgroup).ThedetectionperformancesonSLNidentificationrate,positiveSLNcounts,detectionsensitivity,andfalse-negativeratewerecomparedbetweenthetwogroups.Results:IntheIBgroup,97%(194/200)ofthepatientswhounderwenttheICGandBDdualtracerinjectionshowedfluorescentpositivelymphaticvesselswithin2–5min.TheidentificationrateofSLNswascomparablebetweentheIBgroup(99.0%,198/200)andtheRBgroup(99.6%,270/271)(P=0.79).NosignificantdifferenceswereobservedintheidentificationrateofmetastaticSLNs(22.5%vs.22.9%,P>0.05,RBgroupvs.IBgroup,thesamebelow),positiveSLNcounts(3.72±2.28vs.3.91±2.13,P>0.05),positivemetastaticSLNcounts(0.38±0.84vs.0.34±0.78,P>0.05),SLNBdetectionsensitivity(94.4%vs.92.5%,P>0.05),orfalse-negativerate(5.6%vs.7.5%,P>0.05)betweenthetwogroups.Conclusions:ICGcanbeusedasapromisingalternativetracerforradioisotopeinSLNmapping,andwhenitiscombinedwithBDinlymphangiography,itofferscomparabledetectionsensitivitycomparedtotheconventionallymphaticmappingstrategiesthatarewidelyusedinclinicalpractice.