简介：INTRODUCTIONHydrothermallysynthesized,nanograde,needle-shapeapatitecrystal(nanoapatite)issimilartohoneapatiteinmorphology,crystalstructure,compositionandcrystallinity,andprobablyhasbetterosteoconductivitythanbulkHAceramic.Butwhenthenanoapatiteisdriedinair,itcloggedtomicrometer-sizedapatiteparticles.

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简介：这研究的目的是准备PVA-GAG-COL，并且调查为织物工程用作脚手架的可行性合成的由聚乙烯化合物的酒精(PVA)的材料，glycosaminoglycan(作呕)并且骨胶原(关口)。PVA与各种各样的数量被混合作呕并且关口。不同比例的脚手架能与不同分子的重量和PVA的醇解度和不同数量被获得作呕，它展出了高水位线内容(60%-95%)并且与胀大的比率(120%-620%)显示出不同内部配置。SEM证明不同合成材料有不同多孔的结构。

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简介：Objective:AnovelPVA-CaAlgcompositematerialbypolyvinylalcohol(PVA)andsodiumalginate(SA)wasfabricatedtoinvestigatethefeasibilityservingasascaffoldfortissueengineeringandtofindoutthemostidealproportionaccordingtotheirproperties.Methods:Film,graininessandspongescaffoldsofPVA-CaAlgwerefabricatedbythreedifferentmethods.Watercontentandswellingratioweretested.SEMwasusedtoobservetheconfigurationofthecrosssection.Results:DifferentproportionalscaffoldscouldbeobtainedwithdifferentPVAmolecularweight,alcoholysisdegreeanddifferentSAdosages.Thewatercontentofdifferentscaffoldsrangedfrom48%to93%andshoweddifferentinnerconfigurationwithswellingratiobetween120%and470%.SEMprovedthatdifferentcompositematerialshaddifferentporousstructures.Conclusion:AscaffoldfortissueengineeringwithhighwatercontentandproperswellingratiocanbefabricatedusingPVAandSA.Theporousstructureshowspotentialintissueengineeringandcellculture.

简介：客观:准备nanophase人工的骨头合成支架基于bionics，进满足在骨胶原和无机的部分以及黏合的代理人的不同分子的重量之间的比率怎么不同的理论，和探查影响支架的微观结构和性质。方法：在象内容比率和环境，然后nanophasecollagen/calcic的pH价值那样的某些反应条件下面在一起沉淀期间带钙的无机的分子到deposite到自我装配的骨胶原模板上盐被获得。以便改进机械性质，有性质和可控制的可被细菌破坏的活动被选择为黏合的代理人的稳定的平等者的poly乳的酸(PLLA)，然后瞄准人工的骨头支架(nanophasecollagen/calcicsalt/PLLA合成)被完成。在有isoproanol酒精的准备液体排水量方法以后，扫描电子显微镜(SEM)，传播电子显微镜(TEM)，fourier变换红外线的spectrometry(FTIR)，机械测试系统被执行到测试孔和密度，形态学，符合构造，作文和机械性质，respectively.Results:合成支架主要是的人工的综合骨头部分与B类型碳酸盐代替的骨胶原和钙磷酸盐创作了。crystallinity是低的，并且水晶尺寸到达类似于自然骨头的纳米。有效地使用的PLLA改进能在cancellous标准的地板水平到达的机械性质，并且与80%的高孔开发three-dimensional-porous结构。根据比较，在象黏合的PLLA的增加一样的骨胶原和钙的无机的盐之间的内容比率都在综合支架的微观结构上有效果，这能被看见，PLLA的另外分子的重量在机械properties.Conclusion上有效果:nanophase人工的骨头合成支架由biomimetic综合了进程是最答应为临床的申请的最佳的材料不管怎么从结构，作文和pr判定了之一

简介：Theobjectiveofthispaperistodesignaporouspolyvinylalcohol(PVA)basedoncompositemembranewithcertainmechanicalstrengthandbiocompatibilitiesservingastissueregenerativescaffolds.PVA-glycosaminoglycan(GAG)-typeIcollagen(COL)compositemembranewasfabricatedbyPVAwithdifferentmolecularweight(Mw)andalcoholysisdegree(AD)beingblendedwithcertainamountsofGAGandCOLanddriedat38℃for24h.Thewatercontentofthecompositemembraneswerefrom61.9%to95.1%andswellingratiorangedfrom123.6%to621.7%.Scanningelectronmicroscope(SEM)analysisprovedthatPVA-GAG-COLcompositemembranehasporousandhomogenousstructure.Biocompatibilitytestresultsshowedthatthecompositemembranewasnontoxic,whichcouldpromoteadhesionandproliferationoffibroblastsonthecompositemembrane.Inconclusion,PVA-GAG-COLcompositemembranewithhighwatercontentandswellingratio,suitablemechanicalstrengthandgoodbiocompatibility,haspotentialintissueengineeringandregenerativemedicine.更多还原

简介：Thecruxoftissueengineeringistoconstructhighlyporousthree-dimensionalscaffoldwithdesiredcellsonit.Becausethescaffoldservesasbothaphysicalsupportandanadhesivesubstrateforisolatedcellsduringinvitrocultureandsubsequentimplantation,thematerialsforscaffoldshouldbenon-toxicandbiocompatible,highlyporousandprocessableintodevicesofvariousshapes.

简介：Objective:ToexplorethepreparativemethodandstudythedegradationcharacteristicsofbonerepaircompositeofDL-polylacticacid(PDLLA)/hydroxyapatite(HA)/decalcifyingbonematrix(DBM)invitro.Methods:AnemulsionblendmethodwasdevelopedtopreparethecompositeofPDLLA/HA/DBMinweightratioofPDLLA:HA:DBM=1.5-2:1-1.5:1.Thedynamicchangesofweight,biomechanicalpropertyandpHvalueofPDLLA/HA/DBMandPDLLAinphosphatebufferedsaline(PBS,pH7.4)werestudiedrespectivelythroughdegradationtestsinvitro.Results:Withoutbeingheated,PDLLA,HAandDBMcouldbesynthesizedwiththeemulsionblendmethodasbonecompositeofPDLLA/HA/DBM,whichhadbothosteoconductiveandosteoinductiveeffects.Thediameteroftheaperturewas100-400μmandthegapratewas71.3%.Duringdegradation,thepHvalueofPDLLAsolutiondecreasedlightlywithin2weeks,butdecreasedobviouslyattheendof4weeksandthevaluewas4.0.WhilethepHvalueofPDLLA/HA/DBMkeptquitesteadyandwas6.4attheendof12weeks.TheweightofPDLLAchangedlittlewithin4weeks,thenchangedobviouslyandwas50%ofitsinitialweightattheendof12weeks.WhiletheweightofPDLLA/HA/DBMchangedlittlewithin5weeks,thenchangedobviouslyandwas60%oftheinitialweightattheendof12weeks.TheinitialbiomechanicalstrengthofPDLLAwas1.33MPa,decreasedlittlewithin3weeks,thenchangedobviouslyandkeptat0.11MPaattheendof12weeks.TheinitialbiomechanicalstrengthofPDLLA/HA/DBMwas1.7MPa,decreasedlittlewithin4weeks,thenchangedobviouslyandkeptat0.21MPaattheendof12weeks.Conclusions:Theemulsionblendmethodisanewmethodtopreparebonerepairmaterials.Asanewbonerepairmaterial,PDLLA/HA/DBMismoresuitableforregenerationandcellimplantation,andtheenvironmentduringitsdegradationisadvantageoustothegrowthofbonecells.