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简介：Notopterygiumincisum(QH)hasbeenusedforthetreatmentofrheumatoidarthritis(RA),andvolatileoilsmaybeitsmainlybioactiveconstituents.ThepresentstudywasdesignedtoanalyzethevolatilecompoundsinQHandtodeterminetheanti-arthriticcapacityofNotopterygiumvolatileoilsandthepotentialmechanismofaction.ThevolatilecompoundsanalysiswasconductedbyGC-MS.Theanti-arthriticcapacitytestofthevolatileoilswasconductedonadjuvant-inducedarthritis(AIA)rats.Theanti-inflammatorypropertywastestedinNOreleasemodelinRAW264.7cells.Endothelialcellswereusedtoevaluatetheanti-proliferativeandanti-tubeformativeeffects.70compoundswereanalyzedbyGC-MSinthevolatileoils.NotopterygiumvolatileoilsweakenedtheratAIAinadose-dependentmanner(2,4,and8gcrudedrug/kg).TheNOproductionbyRAW264.7wasdecreasedbymorethan50%inNotopterygiumvolatileoils(5,15,and45μg·mL-1)pretreatedgroups.NotopterygiumvolatileoilsalsoinhibitedEAhy926cellproliferationandfurtherdelayedEAhy926cellcapillarytubeformationinaconcentration-dependentmanner.Theanti-NOproductive,anti-proliferative,andanti-tubeformativeeffectsofNotopterygiumvolatileoilsstronglysuggestedthatthetherapeuticeffectofQHinAIAmightberelatedtothepotentanti-inflammatoryandanti-angiogeniccapacitiesofthevolatileoils.

简介：Carbon-containingrefiactoriesareeasilyoxidizedathightenperature,thusmakingserviceliferapidlydrop.Theanti-oxidationmethods,suchasimpregnationandaddinganti-oxidatonagents,can'tmeettherequire-mentsofindustry'sdevelopmentandsomespecialcases,Byanalyzingthecharcteristicsofseveraloxidesandnon-oxidesrawmaerials,theoxidationresistantmechanismoftherefractoryanti-oxidationcoatings(RAOC),whichpossessthecharacteristcofself-healingathighttemperature,isdiscussed.

简介：ByusingthegeneralizedPoincaréindextheoremitisprovedthatifthen^2criticalpointsofann-polynomialsystemformaconfigurationoftype(2n-1)-(2n-3)+(2n-5)-…+(-1)^n-1,andthe2n-1outmostanti-saddlesformtheverticesofaconvex(2n-1)-polygon,thenamongthese2n-1anti-saddlesatleastonemustbeanode.

简介：目的：分析耳郭刺激抗衰老的疗效，寻求一种简便、安全的抗衰老的保健方法。方法：综合分析耳郭刺激与抗衰老的文献报道，从衰老与耳的关系，耳郭抗衰老的刺激方法、临床应用及机理研究等方面进行探讨。结果与结论：耳郭刺激通常选用与五脏相对应的耳穴心、肝、脾、肺、肾及内分泌、皮质下。耳郭刺激，尤其是耳穴贴压和耳郭按摩法，是简便有效的无创伤性保健、治疗方法，应当在抗衰老中起更大作用。

简介：Thepresentstudywasdesignedtoexaminetheanti-hyperuricemicandanti-inflammatoryeffectsandpossiblemechanismsofvaticaffinol,aresveratroltetramerisolatedfromethanolextractsofDipterocarpusalatus,inoxonate-inducedhyperuricemicmice.At1hafter250mg·kg~(-1)potassiumoxonatewasgiven,vaticaffinolat20,40,and60mg·kg~(-1)wasintragastricallyadministeredtohyperuricemicmiceoncedailyforsevenconsecutivedays.Vaticaffinolsignificantlydecreasedserumuricacidlevelsandimprovedkidneyfunctioninhyperuricemicmice.Itinhibitedhepaticactivityofxanthinedehydrogenase(XDH)andxanthineoxidase(XOD),regulatedrenalmRNAandproteinlevelsofuratetransporter1(URAT1),glucosetransporter9(GLUT9),organicaniontransporter1(OAT1),organiccationtransporter1(OCT1),OCT2,organiccation/carnitinetransporter1(OCTN1),andOCTN2inhyperuricemicmice.Moreover,vaticaffinolmarkedlydown-regulatedrenalproteinlevelsofNOD-likereceptor3(NLRP3),apoptosis-associatedspeck-like(ASC),andCaspase-1,resultinginthereductionofinterleukin(IL)-1β,IL-18,IL-6andtumornecrosisfactor-α(TNF-α)levelsinthisanimalmodel.Additionally,HPLCandLC-MSanalysesclearlytestifiedthepresenceofvaticaffinolinthecrudeextract.Theseresultssuggestthatvaticaffinolmaybeusefulforthepreventionandtreatmentofhyperuricemiawithkidneyinflammation.

简介：目的研究缺血预处理（IPC）对局灶性脑缺血的保护作用以及对TNFRSFexpressedonthemouseembryo（TROY）表达的影响。方法33只雄性成年SD大鼠，随机分为预处理6h组（IVC-6组，11只）、预处理72h组（IPC-72组，11只）和缺血组（CI组，11只）。利用线栓法建立大脑中动脉栓塞（MCAO）致局灶性脑缺血模型。MCAO10min作为IPC,IPC-6和IPC-72组分别在IPC后6h和72h制作短暂性局灶性脑缺血模型。再灌注24h后，对所有动物行神经功能缺损评分（NDS），并处死大鼠取脑，应用2％TTC染色测定梗死容积、TUNEL染色研究细胞凋亡情况和免疫组化观察TROY表达变化。结果与CI组比较，IPC-72组显著改善局灶性脑缺血24h后大鼠神经功能损害[两组评分分别为2（1．5-3），1（0—2）]，减少脑梗死容积[（299．33±70．98）mm^3，（69．25±47．66）mm^3]，抑制细胞凋亡和增强TROY的表达（阳性细胞数分别为42±11，87±17）（P〈0．01）。结论IPC对其后局灶性脑缺血有明显的保护作用．能诱导脑缺血耐受，可能与TROY表达上调相关。

简介：Ｃｈｉｎａ＇ｓＡｎｔｉ－ＪａｐａｎｅｓｅＷａｒＷＯＲＬＤＷＡＲⅡ，ｗｈｉｃｈｅｎｄｅｄｈａｌｆａｃｅｎｔｕｒｙａｇｏｉｎａｃｒｕｓｈｉｎｇｄｅｆｅａｔｆｏｒｔｈｅｆａｓｃｉｓｔｐｏｗｅｒｓ，ｗａｓａｌｉｆｅ－ａｎｄ－ｄｅａｔｈｓｔｒｕｇｇｌｅｂｅｔｗ...

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简介：ThecentralgovernmentwillallocateRMB470millionforAIDSpreventionandcontrol,saidViceHealthMinisterWangLongdetoaJnnepressconferenceheldbytheStateCouncilInformationOffice.

简介：Anti-globalizationtrendsareinplayintheUSandWesternEuropewhereelectoratesarerecalcitranttoallowimmigrantsintotheirsocieties,nationalsovereigntyissoughtincertaingeographicareas,andthenationalmoodseekstosuppressnewlyrisingcountries'tradeanddevelopment.ThecontinuationofeconomicdownturninWesterncountriesisreinforcedbytheirinternalwealthgapandexternalcompetition.Ascapitalism'sdemandforprofitisnowbeingcritiquedalongwiththeemergentprofitprospectstobedeliveredbypendingtechnologicalprogress,thetemperofthetimescouldtemporarilyslowdownbutnotreverseglobalization.Timelydiscussionsaboutreformofinternationaleconomicorderandaboutaneffectivenationaldevelopmentmodelshouldseeksustainablesolutionsforhealthy,stableglobalizationanddevelopmentoftheworldeconomy.

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简介：Therearefewstudiesontheneuroprotectiveeffectsofsyringaldehydeinaratmodelofcerebralischemia.Thestudyaimedtoelucidatethemechanismsunderlyingtheneuroprotectiveeffectsofsyringaldehydeonischemicbraincells.Ratmodelsofcerebralischemiawereintraperitoneallyadministeredsyringaldehyde.At6and24hoursaftersyringaldehydeadministration,celldamageinthebrainofcerebralischemiaratswasobviouslyreduced,superoxidedismutaseactivityandnuclearrespiratoryfactor1expressioninthebraintissueweremarkedlyincreased,malondiadehydelevelwasobviouslydecreased,apoptosis-relatedcysteinepeptidasecaspase-3and-9immunoreactivitywasobviouslydecreased,andneurologicalfunctionwasmarkedlyimproved.Thesefindingssuggestthatsyringaldehydeexertsneuroprotectiveeffectsoncerebralischemiainjurythroughanti-oxidationandanti-apoptosis.

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简介：ChinesetoplegislatorWuBangguoonDec.29,2004promisedthatthe10thNationalPeople'sCongress(NPC）woulddoitsbesttofullyreflectthecommonwillofallChinesepeopleinmakingtheanti-secessionlaw.