简介:摘要目的探讨榄香烯注射液治疗恶性胸腔积液的临床疗效,生活质量及不良反应。方法把42例恶性胸腔积液患者随机分成治疗组及对照组,治疗组22例采用榄香烯注射液胸腔内注射,对照组20例用顺铂胸腔内注射治疗。连用两周,判断临床疗效。结果治疗组较对照组临床疗效、生活质量改善明显,P<0.05,差异有统计学意义;不良反应对照组较治疗组发生率稍多,P>0.05,差异无统计学意义。结论榄香烯注射液胸腔内注射治疗恶性胸腔积液具有良好的临床疗效,不良反应轻,有一定的临床应用价值。
简介:摘要目的探讨榄香烯乳剂联合放疗治疗非小细胞肺癌脑转移的疗效及安全性.方法60例非小细胞肺癌脑转移患者随机分为榄香烯乳联合放疗组30例(治疗组)和单纯放疗治疗组30例(对照组),比较两组的有效率、生活质量及不良反应.结果治疗组有效率为63.3%,对照组有效率为40%,两组差异有统计学意义(P<0.05);治疗组卡氏评分提高率为53.3%,对照组为26.7%,两组差异有统计学意义(P<O.05);治疗组骨髓抑制低于对照组.结论榄香烯乳剂联合放疗治疗非小细胞肺癌脑转移效果优于单纯放射治疗,可提高患者的生活质量,减少不良反应.关键词榄香烯乳剂;放射治疗;非小细胞肺癌;脑转移ClinicalStudyofElemeneEmulsionCombinedwithRadiotherapyintheTreatmentofNon-smallCellLungCancerwithBrainMetastasisPatientsChiHongliang(Departmentofoncology,People'sHospitalofJiaozhoucityinShandongProvince,Jiaozhou266300)AbstractobjectiveToexploretheefficacyofelemeneemulsioncombinedwithradiotherapyintreatmentofnon-smallcelllungcancerwithbrainmetastasispatients.MethodsSixtynon-smallcelllungcancerwithbrainmetastasisweredividedintoelemeneemulsioncombinedwithradiotherapygroup(30cases)andraGdiotherapygroup(30cases).Theefficiencyoftreatment,thequalityoflifeandadversereactionswerecomparedbetweentwogroups.ResultTheefficacyinthetreatmentgroupwas63.3%and40%inthecontrolgroup,Therewasasignificantdifferencebetweenthetwogroupsintermsoftheirtreatmentresponse(P<0.05).andtheKPSinthetreatmentgroupwas53.3%and26.7%inthecontrolgroup,TherewasasignificantdifferencebetweenthetwogroupsintermsofthequaliGtyoflife(P<0.05).andthecasesofbonemarrowsuppressioninthetreatmentgroupwerelessthanthatinthecontrolgroup.ConclusionTheeffectofelemeneeGmulsioncombinedwithradiotherapyfornon-smallcelllungcancerwithbrainmetastasispatientsissuperiortoradiotherapy,whichcanimprovethequalityoflifeandleskseeynwsoraddsversereactions.Elemeneemulsion;Radiotherapy;Non-smallcelllungcancer;Brainmetastasis中图分类号R148文献标识码B文章编号1008-6315(2015)12-1412-01
简介:摘要目的本文研究榄香烯注射液在儿童颅内实体瘤及恶性实体瘤颅内转移病例化疗中的辅助治疗作用.方法2005年9月-2014年12月收集经病理确诊的儿童颅内实体瘤12例,恶性实体瘤颅内转移22例.所有病例随机分成研究组(常规化疗+榄香烯注射液)和对照组(常规化疗组)两组.分析化疗期间以及化疗后骨髓抑制、毒副作用以及不良反应.结果(1)颅内实体瘤12例,其中髓母细胞瘤10例,胶质瘤1例,星形细胞瘤1例,随机分成研究组8例,对照组4例.实体瘤颅内转移病例22例,其中神经母细胞瘤颅内转移6例,视网膜细胞瘤颅内转移16例,随机分成研究组10例,对照组12例.(2)化疗后骨髓抑制情况研究组化疗后白细胞最低值0.40×109/L,对照组白细胞最低值0.07×109/L,研究组与对照组的差异具有统计意义(X2=4.1,P=0.02);研究组外周血白细胞恢复中位时间为(9.5±1.3)d,对照组为(11.9±2.4)d,研究组与对照组的差异具有统计意义(X2=3.9,P=0.025).(3)不良反应分析研究组不良反应发生较对照组少,差异有统计学意义(P<0.05).结论榄香烯注射液联合常规化疗可明显缓解颅内肿瘤及实体瘤颅内转移患儿化疗期间的骨髓抑制,明显减轻不良反应,具有一定临床应用价值.关键词颅内肿瘤;实体瘤;转移;儿童;榄香烯注射液TheClinicalStudyofElemeneInjectioninChildrenwithIntracranialTumorandSolidTumorwithIntracranialMetastasisAbstractObjectiveTostudytheadjuvanttherapywithelemeneinjectioninchemotherapyinchildrenwithintracranialtumorandmalignantsolidtumorwithintracranialmetastasis.Methodsfrom2005Septemberto2014December,atotalof12caseswithpathologicallyconfirmedintracranialtumor,22casesofintracranialmetastasiswithmalignantsolidtumor.Allpatientswererandomlydividedintotwogroups,theonewasthestudygroup(chemotherapy+ElemeneInjection)andtheotherwasthecontrolgroup(chemotherapygroup).SuppressionofbonemarrowduringchemotherapyandtoxicsideeffectsandadversereacGtionsafterchemotherapywereanalyzed.Results(1)12casesofintracranialtumors,included10casesofmedulloblastoma,1caseofglioma,1caseofastrocytoGma,wererandomlydividedintothestudygroupwith8casesandthecontrolgroupwith4cases.22casesofintracranialtumormetastasisincluded6casesdiagGnosedasneuroblastomaand16casesthosewerediagnosedasretinoblastoma.These22caseswererandomlydividedinto10casesinthestudygroupand12casesinthecontrolgroup.(2)bonemarrowsuppressionafterchemotherapyastudygroupofwhitebloodcellsafterchemotherapythelowestvalueofWBCinthestudygroupwas0.40x109/L,thevalueinthecontrolgroupwas0.07x109/L.Thedifferenceshowedthestatisticalsignificancebetweenthethetwogroups(X2=4.1,P=0.02).Mediantimeofperipheralwhitebloodcellsrecoverywas(9.5+1.3)daysinthestudygroup,andthetimewas(11.9+2.4)daysintheconGtrolgroup.Thedifferenceshowedthestatisticalsignificancebetweenthestudygroupandthecontrolgroup(X2=3.9,P=0.025).(3)AdversereactionadGversereactionbetweenthetwogroupswereanalyzedandthedifferencewasstatisticallysignificant(P<0.05).ConclusionElemeneInjectioncombinedwithconventionalchemotherapycansignificantlyrelievebonemarrowsuppressionafterchemotherapytochildrenwiththeintracranialtumorandsolidtumorwithinGtracranKiealymwoertadsstasis,anditcanalleviatetheadversereaction.ElemeneInjectionhascertainvalueofclinicalapplication.intracranialtumor;solidtumor;metastasis;children;elemeneinjection中图分类号R656.1文献标识码B文章编号1008-6315(2015)12-1058-02