简介：In2006ProfessorPatrickW.Serruysintroducedtheuseoffullybiodegradabledrug-elutingscaffolds.Thisnewstentwastoeliminatethepresenceofametalstentwhichwasapermanentmetallicforeignbodyinthecoronarycirculation.Thisrevolutionizedthethenfieldofinterventionalcardiology.

简介：Stentsthatkeepweakenedarteriesfromcollapsinghavebeentruelife-savers,butarenolongerneededoncethearteriesarestrengthened.Now,aresearcherhasdevelopedabiodegradablestentforheartpatientswhichwillcarrydrugswherethey'reneededandwillthendissolve.

简介：Photothermalcancertherapyisanalternativetochemotherapy,radiotherapy,andsurgery.Withthedevelopmentofnanophotothermalagents,thistherapyholdsimmensepotentialinclinicaltranslation.However,thetoxicityissuesderivedfromthefactthatnanomaterialsaretrappedandretainedinthereticuloendothelialsystemslimittheirbiomedicalapplication.Developingbiodegradablephotothermalagentsisthemostpracticalroutetoaddresstheseconcerns.Inadditiontothephysicochemicalpropertiesofnanomaterials,variousinternalandexternalstimuliplaykeyrolesonnanomaterialsuptake,transport,andclearance.Inthisreview,wesummarizednovelnanoplatformsforphotothermaltherapy;thesenanoplatformscanelicitstimuli-triggereddegradation.Wefocusedontherecentinnovativedesignsendowedwithbiodegradablephotothermalagentsunderdifferentstimuli,includingenzyme,pH,andnear-infrared(NIR)laser.

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简介：一系列随机的共聚物(PCLA)被D，L减水乳酸(LA)和-caprolactone(CL)的戒指洞聚合与不同臼齿的比率综合。PCLA基于聚氨酯(PCLAU)被获得由有hexamethylenediisocyanate(HDI)的PCLA和polytetramethylene醚(PTMEG)扩大链。所有PCLAU超过98%与高形状固定性比率展出好形状记忆性质，在第一的超过82%的形状恢复比率骑车，91%在第二骑车。有更少的CL内容的PCLAU证明有更多的CL内容的更快的恢复速度和PCLAU显示出更高的形状恢复比率。扳机温度能被以CL调整LA的臼齿的比率在身体温度附近调节或控制。PCLAU有潜在的应用在植入生物医学的设备，特别为最低限度地侵略的可部署的设备。

简介：Biodegradablepolymerpoly(lactic-co-glycolicacid)(PLGA)wasusedtoencapsulatethepharmacologicalactivitymetaboliteoftolterodinebymeansofO/Wemulsionsolventevaporationmethodviahomogenizationintheemulsificationprocess.Theinfluencesofpreparationparameterswereinvestigated.TheresultsindicatethatincreasingPLGAconcentrationfrom15%to40%madetheencapsulationefficiencyof5-hydroxymethylderivativeoftolterodine(5-HMT)increasedfrom55.39%to76.32%,andtheparticlesizeincreasedfrom34.33μmto70.78μm.Inaddition,whenhomogenizationspeedincreasedfrom850r/minto2300r/min,bothparticlesizeandencapsulationefficiencyofmicrospheresdecreased.Anincreaseinthevolumeofaqueousphaseledtohigherencapsulationefficiencyandbiggerparticlesize.Increasingtemperaturemadeencapsulationefficiencyandparticlesizechangesignificantly.Whilereactiontemperatureincreasedfrom20°Cto50°C,theencapsulationefficiencydecreasedfrom70.44%to24.07%,andparticlesizeincreasedfrom38.66μmto69.38μm.Highreactiontemperature(over40°C)mayleadtoporoussurfaceofmicrospheres.Poroussurface,encapsulationefficiencyandparticlesizeinfluencedontheinvitroreleaseof5-HMTtogether.

简介：Inordertoinvestigatetheimmtmogenicityofthecontrolled-releasemicroencapsulatedhepatitisBvaccineinmice,polyethyleneglycol-poly-dl-lactide(PELA)microsphereswithentrappedHSsAgwerepreparedbydoubleemulsionW/O/Wbasedonsolventextractionmethods.BALB/cmicewereimmunizedwiththeencapsulatedvaccinebyoralfeedingorinjection.Bloodsampleswerecollectedat8^th,10^th,14^thand24^thweeks,respectively,andthelevelsofantibodyresponseweredetectedbyEI.ISA.Itwasfoundthatthescanningelectronmicroscopyshowedthepreparedmicrosphereshadsmoothandsphericalsurface,suitableforvaccinedelivery.Twogroupsofmiceorallyfedwiththeencapsulatedorconventionalrecombinantvaccines,respectively,theresereshowednoobviousdifferenceintheIgGlevels.At14^thweek,thegroupinjectedwithasingledoseofencapsulatedvaccinehadasimilarlevelofIgGresponsetothegroupinjectedwithtwodosesoftherecombinationvaccine.At24^thweek,theIgGlevelsofthegroupinjectedwithtwodosesofencapsulatedvaccinewerehigherthanthoseofthegroupinjectedwithtwodosesoftherecombinationvaccine.ItconcludesthatControlled-releasemicroencapsulatedhepatitisBvaccinepossessesthefeatureofslowlyreleasinginv/voandlongtimesimmtmogenicity.

简介：竹子powder/polycaprolactonecomposites(BPPC)被转矩电流计准备调查配方的效果，处理在变阻器上调节BPPC的逻辑性质。词法行为和BPPC的机械性质也被学习。结果证明合成材料的最佳配方由70%polycaprolactone组成，30%竹子根据体积搽粉，联合代理人的铝酸盐的1.6%，1.2%硬脂的酸，和到竹子的2%石蜡根据质量搽粉比率。处理条件参数的最佳为BPPC在100°C在−1和温度在50r·m作为旋转速度被决定。BPPC(包含30拷贝竹子粉末)拥有的著名界面的相容性和BPPC的机械性质。

简介：Awidevarietyofdifferenttypesofmicroorganismsareknowntoproduceintracellularenergyandcarbonstorageproducts,whichhavebeengenerallydescribedasbeingpoly(β-hydroxybutyrate),PHB,butwhichare,moreoftenthannot,copolymerscontainingdifferentalkylgroupsattheβ-position.Hence,PHBbelongstothefamilyofpoly(β-hydroxyalkanoastes),PHA,allofwhichareusuallyformedasintracellularinclusionsinbacteriaunderunbalancedgrowthconditions.Recently,itbecameofindustrialinteresttoevaluatethesePHApolyestersasnaturalbiodegradableandbiocompatibleplasticsforawiderangeofpossibleapplications,suchassurgicalsuturesorpackagingcontainers.Forindustrialapplications,thecontrolledincorporationofrepeatingunitswithdifferentchainlengthsintoaseriesofcopolymersisdesirableinordertoproducepolyesterswitharangeofmaterialpropertiesbecausephysicalandchemicalcharacteristicsdependstronglyonthepolymercomposition.Such"tailor-made"copolymerscanbeproducedundercontrolledgrowthconditionsinthat,ifadefinedmixtureofsubstratesforacertaintypeofmicroorganismsissupplied,awelldefinedandreproduciblecopolymerisformed.

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简介：Anovelpolymercontainingthesucrosegroupwassynthesizedbyradicalpolymerizationfromanenzymaticallypreparedmonomer,1′-O-vinyladipoyl-sucrose(VAS).TransesterificationreactionofsucrosewithdivinyladipateinanhydrouspyridinecatalyzedbyanalkalineproteasefromBacillussubtilisat60℃for7daysgaveVAS(yield55%)withoutanyblocking/deblockingsteps.ThevinylsucroseestercouldbepolymerizedwithpotassiumpersulfateandH2O2asinitiatortogivepoly(1′-O-vinyladipoyl-sucrose)withMn＝33,000andMw＝53,200,Mw/Mn＝1.61.Thepolymerwasbiodegradable.After6daysinaqueousbuffer(pH7),thisalkalineproteasecoulddegradepoly(1′-O-vinyladipoyl-sucrose)toMnofca.1080,Mw/Mn＝3.30(37℃),andMnofca.5200,Mw/Mn＝2.44(4℃).Thepolymercontainingthesucrosebranchwouldbeafunctionalmaterialinvariousapplicationfields.

简介：Asubstitutedglycolide,3-benzyloxymethyl-1,4-dioxane-2,5-dione,wassynthesized.Itisasuitableprecursorforthepreparationofanewhydrophilicbiodegradablepoly(a-hydroxyacid).ThepolymerizationswerecarriedoutinbulkinthepresenceofSn(Oct)2at120-140℃.TheresultingpolymersweresubjectedtohydrogenolysiswithaPd/Ccatalystinamixedsolventtoremovetheprotectingbenzylgroups.Anovelpoly(a-hydroxyacid)withpendanthydroxygroupswasobtained.Thehydrophilicityoftheresultingpolymerwasevaluatedpreliminarily.``

简介：预防和治疗，而是他们的低水的溶解度，差的稳定性，相反的bioavailability，和低目标特性使在治疗学的剂量管理他们不现实的在癌症的许多phytochemicals表演诺言。这是特别地真的为(−)-epigallocatechingallate，curcumin，橡黄素，resveratrol，和genistein。对为这些自然产品开发新奇交货策略有增加的兴趣。Liposomes，微粒，nanoemulsions，稳固的类脂化合物nanoparticles，nanostructured类脂化合物搬运人并且poly(lactide-co-glycolide)nanoparticles是biocompatible和可被细菌破坏的nanoparticles。那些nanoparticles能增加phytochemicals的稳定性和溶解度，展出一个持续版本性质，提高他们的吸收和bioavailability，保护他们免受早熟的酶的降级或新陈代谢的伤害，延长他们的发行量时间，经由被动或指向的交货改进他们的目标特性到癌症房间或肿瘤，通过阻止他们过早地与生物环境交往降低毒性或副作用到正常房间或纸巾，并且提高纳米技术为为癌症的预防和治疗开发装载phytochemical的nanoparticles打开一扇门。

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简介：Poly-α-aminoacidisakindofbiodegradablebiomedicalmaterial.Itisusedforthepreparationofsustaineddrug-releasedevice.Therearesomeadvantagesofthedrugdeliverydevices.Theycanprovidethetherapywithsideeffects.Thedrugre-leaseismaintainedatabeneficialrateforaprolongedtime.Thepolymermaybebiodegradedafterthedrughasbeenexhausted.

简介：Aseriesofbiodegradablehydrogelsbasedondextranandpoly(L-glutamicacid)werefabricatedforeffectivevancomycinloadingandrelease.Thepreparationofhydrogelswassimplyachievedbyphotocross-linkingofmethacrylateddextranandpoly(L-glutamicacid)-g-hydroxyethylmethacrylate(PGH)inthepresenceofphotoinitiatorI2959.ThestructuresofhydrogelswerecharacterizedbyFTIRandSEM.Theswellingandenzymaticdegradationbehaviorsofhydrogelswereexaminedtobedependentonthepoly(L-glutamicacid)contentinthehydrogels.Thehighercontentofpoly(L-glutamicacid)inthegel,thehigherswellingratioandquickerdegradationwereobserved.Moreinterestingly,thehydrogelwithhigherPGHratioshowedhighervancomycin(VCM)loadingcontent,whichmightbeduetotheelectrostaticinteractionbetweencarboxylategroupsinhydrogelandammoniumgroupofVCM.InvitrodrugreleasefromtheVCM-loadedhydrogelsinaqueoussolutionexhibitedsustainedreleaseofVCMupto72h,whiletheinvitroantibacterialtestbasedontheVCM-loadedhydrogelshowedanefficientMethicillin-ResistantS.aureus(MRSA)inhibitionextendingoutto7days.Theseresultsdemonstratedthatthebiodegradablehydrogelswhichformedbyinsituphoto-crosslinkingwouldbepromisingasscaffoldsorcoatingsforlocalantibacterialdrugreleaseintissueengineering.

简介：INTRODUCTIONApproximately400millionpersonsworldwidesufferfrombladderdisease.Individualswithend-stagebladderdiseaseoftenrequirebladderreplacementorrepair.Severalbladdersubstituteshavebeenattemptedwithbothorganicmaterialsandsynthetics.

简介：electrospun(lactide-co-glycolide)(PLGA)poly，膜被准备并且过去常执行跟腱的反粘附。在整个实验，膜显示出适当降级率，并且降级媒介的pH价值在约7.4点被维持。同时，在vitro并且在vivo的膜的优秀biocompatibility被实时/死了、组织病理学说的分析证实。同时，膜能显著地减少腱粘附并且有效地支持功能的恢复。令人鼓舞的结果被hematoxylin和曙红(H&E)进一步表明，并且Massons三色的染色，和类型我骨胶原immunohistochemical分析。没有处理，与electrospunPLGA膜对待的模型比那关于粘附预防和织物修理显著地更好，这被结束。就降级和粘附预防功效的结果而言，electrospunPLGA膜将是手术后的腱粘附的预防的一个大候选人。