简介：AbstractThe complement system plays a key role in the pathogenesis of autoimmune diseases, which usually injures the kidney. More and more studies have shown the pathogenic role and indicated that abnormal activation of the complement system was highly involved in the outbreak of autoimmune diseases. This review mainly introduced recent studies of complement system activation contributing to the pathogenesis of autoimmune diseases, including systemic lupus erythematosus, antiphospholipid syndrome, antineutrophil cytoplasmic antibody-associated vasculitides, and so on. Understanding the pathogenic roles of complement activation in various autoimmune diseases will identify potential novel therapeutic targets on complement systems.

简介：补充系统对普通病原体在天生的防卫起一个关键作用。补充的激活导致柔韧、有效的解朊的串联，它通过有势力proinflammatory分子的生产在病原体以及在古典煽动性的反应的产生的opsonization和细胞溶解终止。然而，更最近，在有免疫力的反应的补充的角色由于连接补充激活到适应有免疫力的回答的观察被扩展了。补充是在允许综合主人防卫到病原的挑战的天生、适应的有免疫力的回答之间的一座功能的桥，这现在被欣赏。因此，它的函数的研究象主机免疫者反应的组织和组织一样允许卓见进主人病原体相互作用的分子的underpinnings。这评论试图总结在主人防卫上在天生、适应的有免疫力的回答和这些相互作用的后果补充戏的角色。

简介：由T表示复杂射影的花托，我们能在ℂℙ5嵌入表面ℂℙ1×T。在这篇论文，我们计算这表面的分支曲线的补充的基本的组。因为嵌入不是“足够宽大”的，嵌入的表面不属于基本的组是几乎可解决的表面的班：为这些组成立为的一个性质“足够宽大”嵌入钟声。在另一方面，作为它是为非简单地连接的表面的这计算的第一个例子，这个组的结构(是出现在这篇论文)关于任何表面的那些基本的组的结构产生conjecture的延期。

简介：［1］AbdelmotyAI,WilliamsMH.Advancedgeographicdatamodeling.Spatialdatamodelingandquerylanguagefor2Dand3Dapplications.Delft:TheNetherlands,1994［2］FranzA.Voronoidiagrams——asurveyofafundamentalgeometricdatastructure.ACMComputingSurveying,1991,23(3)［3］ZhengC,ChenJ.Organizingandretrievingcadasatraldatabasedonspatio-temporaltopologybetweenfather-sonparcels.JournalofWuhanTechnicalUniversityofSurveyingandMapping,1997,22(3):216～221(inChinese)［4］ChenJ,GoldCM,CuiBL,YongHU,etal.Extendingordinaryplanar-graph-basedspatialdatamodelwithVoronoiapproach.In:ProceedingsofIEAS&IWGIS'97.Beijing,1997.18～20［5］ChenJ,CuiBL.AddingtopologicalfunctionstoMapInfowithVoronoiapproach.JournalofWuhanTechnicalUniversityofSurveyingandMapping,1997,22(3):195～200(inChinese)［6］Clementini,Elisel,PaolinoDiFelice,PetervanOosterom.Asmallsetofformaltopologicalrelationshipssuitableforend-userinteraction.AdvancesinSpatialDatabases,LectureNotesinComputerScience.Springer-Verlag,1993.277～295［7］EdwardsG,LigozatG,FrylA,etal.AVoronoi-basedPIVOTrepresentationofspatialconceptsanditsapplicationtoroutedescriptionsexpressedinnaturallanguage.SpatialDataHandling'96,1996,7B.1～15［8］EgenhoferMJ.Reasoningaboutbinarytopologicalrelations.In:Proceedingsofthe2ndSymposiumonLargeSpatialDatabases.LectureNotesinComputerScience,Springer-Verlag,1991.143～160［9］EgenhoferMJ,FranzosaRD.Point-settopologicalspatialrelations.INT.J.GeographicalInformationSystems,1991,5(2):161～176［10］EgenhoferMJ,HerringJ.Categorizingbinarytopologicalrelationshipsbetweenregions,lines,andpointsingeographicdatabases.TechnicalReport,DepartmentofSurveyingEngineering,UniversityofMaine,Orono,1991［11］EgenhoferMJ,Al-tahaKK.Reasoningaboutgradualchangesoftopologicalrelations,inTheoriesandMet

简介：我们基于clocked传播门为一个布思编码器建议一个新式样计划断热的逻辑(CTGAL)。当时，在新式样，布思编码器的结构的复杂性被减少速度更多样地被改进。断热二是补充收益增殖率,乘法器,乘数蓄电池(MAC)而且一个图案基于CTGAL。计算机模拟结果显示设计电路让正确逻辑工作并且显著地与MAC的相比的更少的能源消耗基于互补金属氧化物半导体(互补金属氧化物半导体)逻辑。

简介：InthispaperwestudythecomputationalperformanceofvariantsofanalgebraicadditiveSchwarzpreconditionerfortheSchurcomplementforthesolutionoflargesparselinearsystems.Inearlierworks,thelocalSchurcomplementswerecomputedexactlyusingasparsedirectsolver.Therobustnessofthepreconditionercomesatthepriceofthismemoryandtimeintensivecomputationthatisthemainbottleneckoftheapproachfortacklinghugeproblems.InthisworkweinvestigatetheuseofsparseapproximationofthedenselocalSchurcomplements.TheseapproximationsarecomputedusingapartialincompleteLUfactorization.Suchanumericalcalculationisthecoreofthemulti-levelincompletefactorizationsuchastheoneimplementedinpARMS.Thenumericalandcomputingperformanceofthenewnumericalschemeisillustratedonasetoflarge3Dconvection-diffusionproblems;preliminaryexperimentsonlinearsystemsarisingfromstructuralmechanicsarealsoreported.

简介：Therapiesthatcomplementfreeradicalscavengingareanimportantapproachfortreatingaginginthebrain.Inthepresentstudy,twoformulationsofmoxaconemoxibustionwereappliedatacupointsZusanli(ST36)andXuanzhong(GB39),andatacupointsBaihui(DU20)andGuanyuan(RN4),inD-galactose-inducedsenilemice.TheresultsrevealedthatmoxaconemoxibustionimprovedtotalsuperoxidedismutaseandCu/Zn-superoxidedismutaseactivityinthehomogenatesofthecerebraltissue,aswellasamelioratingdeficitsinneuronalmorphologyandneuronaldensityinthecerebralcortexandhippocampalCA3.Moxaconemoxibustionalsoenhancedlearningandmemoryfunctionsofsenilemice.MoxaconemoxibustionatZusanli,Xuanzhong,BaihuiandGuanyuanacupointscanthusbeusedtocomplementfreeradicalscavengers,withefficacythatisequaltothatofelectroacupunctureatZusanliandXuanzhong,andsuperiortothatofnimodipinetreatment.

简介：图G的导致的路径数字(G)被定义为G的顶点集合能被划分成的子集的最小的数字以便每个子集导致一条路径。Broere等。如果G是顺序n的一张图，证明了那，那么$\sqrtn\leqslant\rho\left(G\right)+\rho\left({\barG}\right)\leqslant\left\lceil{\tfrac{{3n}}{2}}\right\rceil$。在这份报纸，我们描绘图G为哪个$\rho\left(G\right)+\rho\left({\barG}\right)=\left\lceil{\tfrac{{3n}}{2}}\right\rceil$，在$\rho\left(G\right)上改进更低的界限+\rho\left({\barG}\right)$在一个当n是一个奇怪的整数的平方时，并且为$\rho\left(G\right)决定最好的可能的上面的界限+\rho\left({\barG}\right)$当既不G也不$\barG$孤立顶点时。

简介：AparallelhybridlinearsolverbasedontheSchurcomplementmethodhasthepotentialtobalancetherobustnessofdirectsolverswiththeefficiencyofpreconditionediterativesolvers.However,whensolvinglarge-scalehighly-indefinitelinearsystems,thishybridsolveroftensuffersfromeitherslowconvergenceorlargememoryrequirementstosolvetheSchurcomplementsystems.Toovercomethischallenge,weinthispaperdiscusstechniquestopreprocesstheSchurcomplementsystemsinparallel.Numericalresultsofsolvinglarge-scalehighly-indefinitelinearsystemsfromvariousapplicationsdemonstratethatthesetechniquesimprovethereliabilityandperformanceofthehybridsolverandenableefficientsolutionsoftheselinearsystemsonhundredsofprocessors,whichwaspreviouslyinfeasibleusingexistingstate-of-the-artsolvers.

简介：CD59可以由绑定禁止补充的cytolytic活动到C8/C9并且保护主人房间膜免于相应的膜攻击建筑群(MAC)。然而，CD59是广泛地肿瘤房间上的overexpressed，它在tumorigenesis被含有。相对MAC的CD59的活跃地点仍然被糊涂。是报导MAC有约束力的地点在蛋白质的远侧的脸在残余W40附近集中了的膜上位于一条恐水病的沟的附近。这里，二指导地点的mutagenesis被重叠延期PCR执行删除残余W40地点(异种1，M1)或把C39W40K41改变到W39W40W41(异种2，M2)。然后，我们构造了变异的CD59真核细胞的表达式系统并且与野类型的CD59相比在CHO房间上调查了他们的生物函数。表示recombinant蛋白质的CHO房间的稳定的人口被immunotechnique屏蔽。在30段落culturing以后，蛋白质能被测试。染料版本试金建议M1CD59对补充失去这项活动，当M2CD59稍微增加反补充活动时。结果显示人的CD59的W40对它的活动重要，并且这个地点的禁止可以是增加补充活动并且治疗肿瘤的一个潜在的方法。

简介：无

简介：CD59，属于膜补充规章的蛋白质(mCRPs)，禁止补充的cytolytic活动并且在稳固的癌症是过去表示的，包括卵巢癌症。现在的学习的目的是构造编码shRNA的recombinantretrovirus指向的人的CD59并且感染A2780房间以便调查在减少的CD59表示和卵巢癌症的tumorigenesis之间的关系。siCD59和siCD59-C被分别地定序的PCR，限制endonuclease分析和DNA成功地构造并且识别。siCD59能高效地感染A2780房间，它被西方的弄污证实。当与新鲜正常人的浆液孵化了时(8%，v/v)为在37掳C的1h，房间生存能力被减少，房间损坏在感染的siCD59被增加与siCD59-C相比的A2780房间感染了房间。这导致了caspase-3的激活。在感染的房间用染色的Hoechst与hypercondensed原子核被显示出的siCD59的apoptosis。同时，在裸体老鼠的卵巢肿瘤接枝的重量显著地与siCD59-C组的相比在siCD59组被减少。并且在在siCD59组的肿瘤织物的CD59蛋白质的表示显著地被减少。这些结果建议在经由调停retrovirus的RNAi的卵巢癌症房间的CD59silencing能提高调停补充的房间损坏，禁止卵巢癌症的生长。CD59可能是为在卵巢癌症的基因治疗的一个潜在的目标。