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简介：摘要本文测定90例临床恶性肿瘤患者血清GP-DA活力，发现肝癌患者GP-DA活力升高，胃癌GP-DA活力显著减低。肝癌患者血清GP-DA活力与r-GT呈正相关(r=0.7649)、与AFP无相关(r=0.1024)。

简介：AbstractBackground:The prevalence of skin diseases and diabetes mellitus (DM) are prominent around the world. The current scope of knowledge regarding the prevalence of skin diseases and comorbidities with type 2 DM (T2DM) is limited, leading to limited recognition of the correlations between skin diseases and T2DM.Methods:We collected 383 subjects from the Da Qing Diabetes Study during the period from July 9th to September 1st, 2016. The subjects were categorized into three groups: Normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and T2DM. The prevalence and clinical characteristics of skin diseases were recorded and investigated.Results:In this cross-sectional study, 383 individuals with ages ranging from 53 to 89-year-old were recruited. The overall prevalence of skin diseases was 93.5%, and 75.7% of individuals had two or more kinds of skin diseases. Additionally, there were 47 kinds of comorbid skin diseases in patients with T2DM, of which eight kinds of skin diseases had a prevalence >10%. The prevalence of skin diseases in NGT, IGT, and T2DM groups were 93.3%, 91.5%, and 96.6%, respectively; stratified analysis by categories showed a statistically significant difference in "disturbances of pigmentation" and "neurological and psychogenic dermatoses" . The duration of T2DM also significantly associated with the prevalence of "disturbances of pigmentation" and "neurological and psychogenic dermatoses" . Subsequently, the prevalence of "disturbances of pigmentation" was higher in males than females in NGT (P < 0.01) and T2DM (P < 0.01) groups. In addition, the difference in the prevalence of "disturbances of pigmentation" was also significant in NGT and T2DM groups (P < 0.01).Conclusions:There was a high prevalence of skin diseases in the Da Qing Diabetes Study. To address the skin diseases in the Da Qing Diabetes Study, increased awareness and intervention measures should be implemented.

简介：DA（柔红霉素＋阿糖胞苷）方案是目前治疗急性髓细胞白血病（AML）标准方案之一，综合有关资料统计其完全缓解（CR）率在65％左右。但有部分患者经治疗后仅达部分缓解（PR）或未缓解（NR），需使用CAG方案（粒细胞集落刺激因子＋阿柔吡星＋阿糖胞苷）进行第2次化疗，以达到较满意的效果。我科2007年1月至2009年3月用DA联合CAG方案治疗AML，并对治疗后引起的不良反应实施了有效的护理，取得了较好的临床效果，现报道如下。

简介：摘要目的评价胰高血糖素样肽-1和葡萄糖依赖性促胰岛素多肽双受体激动剂DA-JC4对老龄大鼠术后神经炎症反应的影响。方法清洁级健康SD大鼠45只，雌雄不拘，21～23月龄，体重530～630 g，采用随机数字表法分为3组(n＝15)：假手术组(S组)、外科手术组(O组)和DA-JC4组(G组)。O组和G组水合氯醛麻醉下行剖腹探查术。G组分别于术毕即刻、术后24和48 h时腹腔注射DA-JC4 10 nmol/kg(溶于1 ml无菌生理盐水)。术后第3天采用Western blot法测定海马Bax、Bcl-2、活化的caspase-3、Beclin-1、微管相关蛋白1轻链3Ⅱ(LC3Ⅱ)、高迁移率族蛋白B1(HMGB1)、IL-1β和TNF-α的表达水平。术后第14-18天行Morris水迷宫实验测试认知功能。结果与S组比较，O组术后第15-18天、G组术后第18天逃离潜伏期延长，O组和G组穿越原平台次数减少，目标象限停留时间缩短，海马活化的caspase-3、Bax、LC3Ⅱ、HMGB1、IL-1β和TNF-α表达上调，Bcl-2、LC3Ⅱ和Beclin-1表达下调(P<0.05)；与O组比较，G组术后第15-18天逃离潜伏期缩短，穿越原平台次数增加，目标象限停留时间延长，海马活化的caspase-3、Bax、HMGB1、IL-1β和TNF-α表达下调，Bcl-2、LC3Ⅱ和Beclin-1表达上调(P<0.05)。结论DA-JC4减轻老龄大鼠术后认知功能障碍的机制可能与抑制神经炎症反应有关。

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简介：摘要目的评价DA-JC4预处理对睡眠剥夺老龄大鼠认知功能的影响。方法清洁级健康雄性SD大鼠36只，18~22月龄，体重500~600 g，采用随机数字表法分为3组（每组12只）：对照组（C组）、睡眠剥夺组（S组）和DA-JC4组（D组）。S组和D组采用改良多平台水环境法建立老龄大鼠睡眠剥夺模型。D组每天10：00腹腔注射DA-JC4 25 nmol/kg（溶于1 ml生理盐水中），连续注射6 d，C组和S组于相同时间腹腔注射等量生理盐水。大鼠于睡眠剥夺结束后行Morris水迷宫实验，连续4 d，记录各组小鼠穿越平台次数及目标象限停留时间。于第5天水迷宫实验结束后处死大鼠取海马组织，采用ELISA法检测海马组织IL-1β、TNF-α含量，采用Western blot法检测海马细胞核NF-κB p65表达。结果与C组比较，S组和D组Morris水迷宫实验穿越平台次数减少，目标象限停留时间缩短，海马组织IL-1β、TNF-α含量增加，海马细胞核NF-κB p65表达上调（P<0.05）；与S组比较，D组Morris水迷宫实验穿越平台次数增多，目标象限停留时间延长，海马组织IL-1β、TNF-α含量降低，NF-κB p65表达下调（P<0.05）。结论DA-JC4预处理可改善睡眠剥夺老龄大鼠的认知功能，其机制可能与抑制海马组织炎性反应有关。

简介：AbstractObjective:Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephaly/CZS after the ZIKV outbreak in defined geographic areas. This study aimed to identify adverse outcomes in live births of fetuses exposed in utero to the ZIKV, compared to unexposed births, as well as maternal sociodemographic, delivery, and birth characteristics.Methods:Here, we conducted a cross-sectional observational study to investigate the characteristics of all live births in the city of Tangará da Serra, Mato Grosso, Brazil, in 2016, after the outbreak of ZIKV infection in late 2015. All live births of children to women residing in the municipality of Tangará da Serra between January 1 and December 31, 2016, were evaluated, and head circumference was measured at birth and after 24 hours. Children born with microcephaly or a maternal history of confirmed or suspected prenatal ZIKV infection were evaluated by a multidisciplinary team. The outcomes of the exposed and non-exposed children were compared. Prevalence ratios and their respective 95% confidence intervals were calculated for sociodemographic, delivery, and live birth characteristics.Results:Of 1,441 live births, 106 (7.3%) were from mothers with confirmed or highly probable exposure to ZIKV. The prevalence of severe congenital microcephaly (41.7/10,000) in Tangará da Serra in 2016 was ten-fold higher than that in Latin America before 2015.Conclusion:This study may serve as a model to investigate possible outbreaks of infections in a defined geographical space in the future.

简介：摘要目的探讨钩藤碱在帕金森病(PD)大鼠模型中对纹状体多巴胺(DA)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平表达的调节作用。方法首先从中药钩藤中分离提取出钩藤碱。其次采用脑内定位注射6-OHDA制备部分损伤PD大鼠模型，采用正常对照组、模型对照组和钩藤碱组来进行分析。用生化法对大鼠脑中DA、及血清中SOD、MDA活性进行测定，分析钩藤碱对其活性的影响。结果给药30天后，钩藤碱组DA水平密度明显高于模型对照组(P<0.01)。在SOD水平方面，钩藤碱组显著高于模型组(P<0.05)；而MDA含量与正常对照组比较，而钩藤碱组与正常对照组接近，显著低于模型对照组组(P<0.05)。结论钩藤碱对帕金森大鼠脑内SOD、DA、MDA表达的具有调节作用，提示其作为帕金森症的治疗或者预防药物具有一定的开发价值。

简介：摘要目的探讨DA-EPOCH治疗初诊非霍奇金淋巴瘤的疗效及安全性。方法收集37例经病理确诊的初诊非霍奇金淋巴瘤患者，使用DA-EPOCH方案行6-8个疗程化疗后评估疗效及不良反应，具体为依托泊苷（VP-16）50mg/m2，多柔比星（ADM）或吡柔比星（THP）10mg/m2，长春新碱（VCR）0.4mg/m2持续静脉滴注，第1天至第4天，环磷酰胺（CTX）750mg/m2静脉滴注第5天，地塞米松15mg静脉滴注第1天至第5天，21d为1个疗程。结果37例患者总有效率为71%，骨髓抑制及神经毒性为主要不良反应。结论DA-EPOCH方案治疗初诊非霍奇金淋巴瘤缓解率高，安全性好。

简介：摘要：沙枣的主要活性成分沙枣多酚是富含酚羟基结构的化合物，作为天然的抗氧化剂，植物多酚在医药、食品、化妆品以及电化学等很多领域被广泛应用。本论文以 XDA-1型大孔树脂为分离材料，乙醇为洗脱剂，通过单因素考察得出：当洗脱剂浓度为 50%、洗脱剂用量为 4BV、洗脱剂 pH值为 4时，可使 XDA-1型大孔树脂对沙枣多酚的解吸率达到最高。

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简介：在公园里，很多老人喜欢把腿放在树上或者栏杆上压腿，甚至攀比谁抬得高。专家指出，60岁后老年人身体平衡能力较弱，像压腿、踢腿等容易使老年人失去平衡的锻炼方法，尽量不要去尝试。

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简介：摘要急性重症肝炎(暴发性肝炎)病死率高，无满意的治疗方法，故探讨较好的综合基础治疗措施是非常必要的。国内外学者均在研究寻找可以降低病死率提高成活率的药物或方法考虑到急性重症肝炎的病变主要是肝细胞大量坏死或水肿变性，所致肝功能衰竭，尤其是维持机体生理活动的代谢、解毒、凝血等重要功能受累，表现出肝脏缩小，肝功能损害不同程度昏迷及凝血机制障碍，目前抢救治疗暴发性肝炎的治疗原则是针对病情发展各阶段的主要矛盾，应用对症与支持的综合基础治疗维持病人生命，以期促进肝细胞的再生，以待病人恢复。应治疗纠正一高(血氨增高，并有假性神经传导阶质影响神经传导)，三低(低血糖、低血钾、低白蛋白血症)，二水肿(脑水肿及继发性肺水肿)，出血及肝肾综合征(急性肾功能衰竭)，并应采取措施抗病毒感染，促进肝细胞再生，调节免疫功能。我科2009年收治急性重症肝炎60例，取得较满意效果。现报告如下。

简介：摘要目的急性胃炎的治疗效果。方法将相关60例患有急性胃炎疾病的患者按治疗方式进行分组，分为实验组和常规组，每组各30例。对实验组患者进行结合现代医疗科技的对症治疗。结果实验组中患者对治疗效果十分满意有27例，较为满意有2例，满意率为98%，对常规组患者按照常规的形式进行一般治疗，十分满意2例，较为满意有27例，不满意有1例，满意率为百分之九十五。结果显示实验组对治疗效果的满意程度高于常规组的，差异具有统计学意义（P＜0.05）。结论急性胃炎对症治疗方式提高了患者的恢复速度，提升了患者的满意程度，是合理化的治疗方式，推荐对患者进行推广。

简介：摘要目的探讨脑梗死患者的优质护理方法，总结相关护理经验，以提高临床护理质量。方法对60例脑梗死患者采取监护护理、基础护理、用药护理、心理护理、康复护理的护理措施及健康教育。结果本组60例患者痊愈32例，好转28例，无死亡病例。结论科学合理的护理方法和全面的健康教育有利于提高患者的治愈率和病后生存质量。值得临床探讨、应用。