简介：AbstractPreeclampsia (PE) is one of the leading causes of maternal and perinatal morbidity and mortality worldwide. This disorder has profound short-term and long-term impacts on both the affected woman’s and her child’s health. Early-onset PE requiring preterm delivery (preterm PE) is of particular importance because it is associated with a higher risk of adverse pregnancy outcomes than term PE. First trimester screening model developed by the Fetal Medicine Foundation (FMF), which uses Bayes-theorem to combine maternal characteristics and medical history together with measurements of mean arterial pressure, uterine artery pulsatility index, and serum placental growth factor, has been proven to be effective and have superior screening performance to that of traditional risk factor-based approach for the prediction of PE. Identification of high risk pregnant women for preterm PE and giving aspirin prophylaxis before 16th week of gestation would reduce the incidence of preterm PE. In Asia, although the prevalence of PE is slightly lower than the global estimation, early screening and prevention of this life-threatening condition is still crucial. The FMF Bayestheorem based screening method has been validated in a large-scale prospective Asia-wide study and revealed that the first trimester triple test achieves the highest detection rate, compared with the traditional risk factor-based approaches, and that the screening performance is comparable to the published data from the FMF in East Asian women. However, in order to achieve optimal screening performance, the key is to establish standardized methods for biomarker measurements and regular biomarker quality assessment, as each biomarker is susceptible to inaccurate measurement, thus affecting performance of screening. Furthermore, it is of great importance to emphasize that the optimal preventive effect of aspirin on preterm PE is clearly associated with good compliance to treatment. In conclusion, global implementation of an effective first trimester "screen and prevent" program for preterm PE would provide the opportunity to reduce the risk of both short-term maternal and perinatal morbidity and mortality, with the possibility of intergenerational prevention of future chronic diseases for both the mother and her offspring.

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简介：蜕膜的生来的杀手(dNK)房间表示一连串的激活受体在早怀孕期间调整胎盘的免疫和开发。我们在在dNK和trophoblast房间之间的怀孕期和相互作用的第一和第二个三个月期间调查了人的dNK房间的功能的特性。尽管CD56+在全部的CD45+白血球之中的CD16−dNK没在这个句号，激活的受体的表示，NKp80和NKG2D上变化，极大地upregulated。我们与第二三个月蜕膜比较在第一个三个月在最近观察了extravilloustrophoblast房间的一个显著地更高的数字到dNK房间。当co有教养时，由第一个三个月dNK房间的NKG2D表示与HTR-8trophoblast房间线被减少。在第二个三个月，dNK激活的功能的标记，即，angiogenic因素生产(例如，脉管的endothelial生长因素，interleukin-8，interferon-gamma)，尽管有NKp80或NKG2D表面表示的增加的仍然是的马厩。而且，dNK房间的degranulation能力由CD107a估计了在第二个三个月被减少。我们建议在第一个三个月，trophoblast-dNK相互作用与压制的激活的显型产生dNK房间的一张人口。在第二个三个月，trophoblast-dNK相互作用的损失导致了dNK房间功能的抑制，尽管他们的激活的受体表示被增加。我们推测在怀孕期间，二机制操作调制激活受体的dNK房间activation:suppression，这由在第二个三个月联合的receptor-ligand的trophoblasts和解开在第一个三个月铺平。

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简介：一、从词性上看区别first可用作形容词或副词,有时还可用作代词;而atfirst作为介词短语,只起副词作用(在句中用作状语)。如:

简介：布什总统的就职仪式刚刚结束，布什夫人劳拉就成为美国新的“FirstLady”(第一夫人。那么，“FirstLady”的称呼是从何而来的呢?

简介：小布什的总统就职仪式刚刚结束，布什夫人劳拉成为美国新的“FirstLady”(第一夫人)。那么，“FirstLady”的称呼是从何而来的呢?

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简介：Atdusk,theweatherbecamecolder,theskywasgray,thecoldwindwasblowingstrongly,itwasgoingtosnowsoon.

简介：如果你有什么明星真实麻辣的趣闻秘事，快快发邮件到easyknowstar@ieasy.tv告诉我们！

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简介：“如果我真的赢得了这个奖项．得奖的那个晚上．我可能会把奖杯留在记分台上．让球迷们知道这是给他们的。我想以此来表达我对他们的感激。”

简介：因为不想重头制造轮子，所以会从设计模式中寻求协助一学习了解、甚或组合创造他人的经验与实际的精华。

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简介：Afirstgradeteachercollectedwell-knownproverbs.Hegaveeachkidintheclassthefirsthalfoftheproverb,andaskedthemtocomeupwiththerest.Hereiswhatthekidscameupwith:

简介：Atthefootofahill,Silentlyliesthefirststep.Nosorrow,Notrouble,Noworry,Nocomplaint.Forthejoyoftravellers.Thetrampleoffeetyebear,Fromrainandwindyesuffer.SeeingpeoplegettingtothehilltopYetyou’restilllyingatthefoot

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