简介：

简介：Traditionally,thematerialswhichareregardedasantigensrecognizedbyγδTlymphocytesareproteinandcarbohydrate,notnucleicacidorlipid.Recently,ithasbeendemonstratedthatγδTcellscanrecognizelipidAanddirectlyinduceimmuneresponsesthatinvolveCD1(clusterofdifferentiationtype1)familyandTolllikereceptors(TLRs).Thisisareviewabouttheinteracting-mechanism,immunologicaleffectandclinicalapplicationofthem.Cellular&MolecularImmunology.

简介：

简介：

简介：沿着山东省的东方海岸有教养的牡蛎的化学成分的每月的差别被分析。部件分析了包括的肝糖，丰满的酸和免费氨酸(FAA)。肝糖的内容在1月和三月高(2.89并且2.82g(100g)~(-1)平均，分别地)并且在10月低(2.07g(100g)~(-1)平均)。在10月的中立类脂化合物的低内容反映了牡蛎的相对差的营养的价值(1.42g(100g)~(-1)平均)。牡蛎的主要的丰满的酸是十六酸酸(16:0)，油的酸(18:1)，eicosapentaenoic酸(EPA，20:5ω-3)并且docosahexaenoic酸(DHA，22:6ω-3)。牡蛎的majorFAAs是公牛的，Glutamicacid，Glycin，丙氨酸，精氨酸和脯氨酸。公牛有它的内容的最丰富的FAA从603mg(100g)正在~(-1)到1139mg(100g)~(-1)。肝糖的高内容，丰满的酸和FAA显示出的多元不堡和沿着山东省的东方海岸有教养的那只牡蛎是在1月和三月好的营养联盟者。

简介：ObjectivesToobservetherelationshipbetweenThyroidHormone(TH)levelandbloodlipidlevelinthehealthyelderlywiththerapyofsmalldoseofTH.MethodsAtotalof120healthyoldpersonswererandomlydividedintotwogroups:60oldpersonsastreatmentgroupandother60personsascontrolgroup.Eachpersoninthetreatmentgrouptookathyroidtablet10mgdailycontinuouslyforsixmonthswhilethecontrolgrouptookVitB130mgdailyinsteadofthyroidtablet.ThelevelofTH,M-TSH,FT3,FT4,TT4,rT3,TC,TG,LDL-C,HDL-C,ApoA1weremeasuredintwogroupsbeforeandafterreceivingTHorVit.B1treatment.ResultsInthetreatmentgroupthelevelofTHincreasedobviously.AndTC,TG,LDL-ClevelsdecreasedalsotosomeextentwhileHDL-C,ApoAllevelsincreasedslightlywhichwassignificantwhencomparedwiththecontrolgroupandpre-treatmentgroup.ConclusionsTousesmalldoseofTHassupplementtreatmentcanincreasetheTHlevelofhealthyoldpersonsanddecreasethei

简介：

简介：我们关于Blattellagermanica男性的表皮、内部的类脂化合物的研究的结果在B的表皮、内部的类脂化合物的作文在变化上提供新信息。在到杀虫药剂的存在的暴露以后的germanica男性。煤气的层析和煤气的层析团spectrometry分析被用来鉴别在男性和男性的表皮、内部的类脂化合物作文暴露了到杀虫药剂并且确定。有显著地有碳原子的一个偶数的更多的酸在里面分子，和这些通常也在更高的集中。下列酸在更高的集中：C16:0和C18:1，C18:2，C18:0。在暴露于杀虫药剂的男性和男性，24丰满的酸从C6到C22是坚定的。然而，有在B的表面类脂化合物的丰满的酸的一个显著地更高的内容。在到杀虫药剂的暴露以后的germanica男性。我们的结果显示n链烷的一个更高的内容，甾醇，特别地胆固醇，丰满的酸，和在B的丰满的酸甲基酉旨。在到chlorpyrifos的暴露以后的germanica表面比在男性，那没被暴露。

简介：

简介：Objective:Tostudytheanti-inflammatoryactivityandtissuedistributionpatternsofintravenousemulsionofdexamethasoneacetateinmice.Methods:Theanti-inflammatorysolutionforinjectionandLimethasone(Jepaneseproduct)givenintravenouslywereevaluatedbyusingthepreformedcarrageenangranulomapouchmethodinrats.Results:Theanti-inflammatoryactivityofdexamethasoneacetateemulsionatlowdoseof0.05mg.kg1wasaspotentasdexamethasonesodiumphosphatesolutionathighdoseof0.3mg.kg1.Thedistributionpatternsinmicetissuesof[^3H]dexamethasoneacetateemulsionand[^3H]dexamethasonesodiumphosphatesolutioninmiceweremarkedlydifferent.Dexamethasoneacetateemulsionshowedamuchhigherconcentrationintheliver,spleen,lung,andinflamedtissues,whereasdexamethasonesodiumphosphatehadahighconcenti,moninthemusclesofvastuslateralis.Theseresultsmayindicatethatdexamethasoneincoporatedinlipidemulsionwastakenupbythereticuloendothelialsystemandinflammatorycellsmuchmorethandexamethasonesodiumphosphatesolution.Conclusion:Whendexamethasoneacetatewasincorporatedinemulsion,thedistributionpatternsintissueswerechangedandtheyhadastrongeranti-inflammatoryactivity.

简介：

简介：Bothendotheliallipasegene(LIPG)584C>T(rs2000813)polymorphismandalcoholconsumptionmodulateserumlipidlevels.Buttheirinteractionsonserumlipidprofilesarenotwellknown.ThepresentstudywasundertakentodetecttheinteractionsofLIPG584C>Tpolymorphismandalcoholconsumptiononserumlipidlevels.GenotypingoftheLIPG584C>Twasperformedin763nondrinkersand520drinkersaged15-85.Interactionsbetweenthegenotypesandalcoholconsumptionwereassessedbyusingacross-productterm.Thelevelsofserumtotalcholesterol(TC),triglyceride(TG),high-densitylipoproteincholesterol(HDL-C),apolipoprotein(Apo)AI,andtheratioofApoAItoApoBwerehigherindrinkersthaninnondrinkers(P<0.01forall).Therewasnosignificantdifferenceinthegenotypicandallelicfrequenciesbetweennondrinkersanddrinkers.ThelevelsofserumTC,HDL-CandApoAIinnondrinkersweredifferentamongthethreegenotypes(P<.05-.01).ThesubjectswithCTgenotypehadhigherserumTC,HDL-CandApoAIlevelsthanthesubjectswithCCgenotype.ThelevelsofserumHDL-CandApoAIindrinkersweredifferentamongthethreegenotypes(P<.001andP<.05;respectively).TheindividualswithTTgenotypehadhigherserumHDL-CandApoAIlevelsthantheindividualswithCCandCTgenotypes.ThelevelsofTCinnondrinkerswerecorrelatedwithLIPG584C>Tallele(P<.05),whereasthelevelsofTGandHDL-CwereassociatedwithLIPG584C>Talleles(P<.05)andgenotypes(P<.05);respectively.ThepresentstudysuggeststhatthesubjectswithTTgenotypebenefitedmorefromalcoholconsumptionthanthesubjectswithCTandTTgenotypesinincreasingserumHDL-CandApoAIlevels.

简介：Objective:Toobservetheeffectofacupunctureandmoxibustiononbloodlipidlevelinapoplectichemiplegiapatientswithomalgia.Methods:90casesofapoplecticherniplegiapatientswithomalgiawererandomlydividedintosimpleacupuncture(n=30),acupuncture+medication(n=30)andsimplemedication(n=30)groups.MainacupointsusedwereShuigou(GV26),Neiguan(PC6),Tongli(HT5),

简介：AbstractBackground:Thyroid dysfunction is associated with cardiovascular diseases. However, the role of thyroid function in lipid metabolism remains partly unknown. The present study aimed to investigate the causal association between thyroid function and serum lipid metabolism via a genetic analysis termed Mendelian randomization (MR).Methods:The MR approach uses a genetic variant as the instrumental variable in epidemiological studies to mimic a randomized controlled trial. A two-sample MR was performed to assess the causal association, using summary statistics from the Atrial Fibrillation Genetics Consortium (n = 537,409) and the Global Lipids Genetics Consortium (n = 188,577). The clinical measures of thyroid function include thyrotropin (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) levels, FT3:FT4 ratio and concentration of thyroid peroxidase antibodies (TPOAb). The serum lipid metabolism traits include total cholesterol (TC) and triglycerides, high-density lipoprotein, and low-density lipoprotein (LDL) levels. The MR estimate and MR inverse variance-weighted method were used to assess the association between thyroid function and serum lipid metabolism.Results:The results demonstrated that increased TSH levels were significantly associated with higher TC (β = 0.052, P = 0.002) and LDL (β = 0.041, P = 0.018) levels. In addition, the FT3:FT4 ratio was significantly associated with TC (β = 0.240, P = 0.033) and LDL (β = 0.025, P = 0.027) levels. However, no significant differences were observed between genetically predicted FT4 and TPOAb and serum lipids.Conclusion:Taken together, the results of the present study suggest an association between thyroid function and serum lipid metabolism, highlighting the importance of the pituitary-thyroid-cardiac axis in dyslipidemia susceptibility.

简介：目的:利用生物传感器跟踪技术从抗炎中药中筛选出具有拮抗内毒素的中药,为进一步对中药拮抗内毒素活性成分的分离纯化提供实验依据.方法:将革兰阴性细菌的脂质A(LipidA)包被于生物传感器的非衍生板建立靶点,跟踪测定赤芍、大黄、黄芩等78种中药的水提物和醇提物与LipidA的结合活性,再将筛选出的中药去鞣质后与定量的内毒素(LPS,20、50ng·ml-1)37℃孵育30min后,测定孵育后的样品与LipidA的结合情况,以评价样品内的活性物质含量.结果:在所筛选的78种中药中有12种中药的水提物与LipidA具有较高的亲和活性,在这12种中药中有6种中药的醇提物与LipidA也具有较高的亲和活性;通过对所筛选出的12种中药的水提物去除鞣质后与LPS的消耗实验,发现所筛选出的12种中药均含有除鞣质以外的与lipidA具有特异性结合的物质,并且12种中药中能与LipidA发生特异性结合作用的活性物质含量存在较大的差异.结论:生物传感器跟踪技术是一种快速、准确、有效的筛选平台,筛选出的12种中药均含有非鞣质类能与lipidA发生特异性结合作用的物质,为进一步对12种中药抗内毒素有效部位或单体的分离提供了重要的实验依据.

简介：Pomegranateleaf(PGL)hasadefiniteroleinregulatinglipidmetabolism.However,pharmacokineticresultsshowthemainactiveingredient,ellagicacid,inPGLhasloweroralbioavailability,suggestingthatthelipid-loweringeffectofPGLmayactthroughinhibitinglipidabsorptioninthesmallintestine.Ourresultsdemonstratedthatpomegranateleafanditsmainactiveingredients(i.e.,ellagicacid,gallicacid,pyrogallicacidandtannicacid)werecapableofinhibitingpancreaticlipaseactivityinvitro.Incomputationalmoleculardocking,thefouringredientshadgoodaffinityforpancreaticlipase.AcutelipidoverloadexperimentsshowedthatalargedosageofPGLsignificantlyreducedserumtotalcholesterol(TG)andtriglycerides(TC)levelsinadditiontoinhibitingintestinallipaseactivity,whichdemonstratedthatPGLcouldinhibitlipaseactivityandreducetheabsorptionoflipids.WealsofoundthatPGLcouldreversethereducedtight-junctionproteinexpressionduetointestinallipidoverload,promoteOccludinandClaudin4expressioninthesmallintestine,andenhancetheintestinalmucosalbarrier.Inconclusion,wedemonstratedthatPGLcaninhibitlipidabsorptionandreducebloodTGandTCbytargetingpancreaticlipase,promotingtight-junctionproteinexpressionandtherebypreventingintestinalmucosadamagefromanoverloadoflipidsintheintestine.

简介：AbstractEbola virus (EBOV) is one of the most pathogenic viruses in humans which can cause a lethal hemorrhagic fever. Understanding the cellular entry mechanisms of EBOV can promote the development of new therapeutic strategies to control virus replication and spread. It has been known that EBOV virions bind to factors expressed at the host cell surface. Subsequently, the virions are internalized by a macropinocytosis-like process, followed by being trafficked through early and late endosomes. Recent researches indicate that the entry of EBOV into cells requires integrated and functional lipid rafts. Whilst lipid rafts have been hypothesized to play a role in virus entry, there is a current lack of supporting data. One major technical hurdle is the lack of effective approaches for observing viral entry. To provide evidence on the involvement of lipid rafts in the entry process of EBOV, we generated the fluorescently labeled Ebola virus like particles (VLPs), and utilized single-particle tracking (SPT) to visualize the entry of fluorescent Ebola VLPs in live cells and the interaction of Ebola VLPs with lipid rafts. In this study, we demonstrate the compartmentalization of Ebola VLPs in lipid rafts during entry process, and inform the essential function of lipid rafts for the entry of Ebola virus. As such, our study provides evidence to show that the raft integrity is critical for Ebola virus pathogenesis and that lipid rafts can serve as potential targets for the development of novel therapeutic strategies.

简介：EffectofplasmacoronadischargesonthepH,wholecelllipidsandDNAofbacteriaisinvestigated.Resultsshowedanincreaseintheaciditylevelsofwaterduetoplasmareactivespecieswhich,however,werenotresponsibleforbacterialcelldeath.Nochangesinthewholecelllipidcontentswereobserved,whileDNAafterplasmatreatmentshoweddeteriorationoftheamplifiedsequences,indicatingthepossibleoccurrenceofDNAdegradation.Inconclusion,reactivespeciesproducedbyplasmadischargesaffectsDNA,possiblycontributingtocelldeath.

简介：BackgroundInthisstudy,weaimedtoevaluatetheimpactofabnormalglucose,lipidandCystatin-ConthevirtualPvectorcharacteristics,whichhaven’tbeenreportedinpreviousstudies.Methods204ofnon-diabetesmellitus(NDM),130ofDM(type2)and39ofimpairedglucosetolerance(IGT)patientswereconsecutivelyandretrospectivelyrecruited.Weselectedaone-minutelengthofelectrocardiogramat4AMforanalysis.Afteraseriesofcalculatingalgorisms,weobtainedthevirtualplanarPvectorparameters.ResultsTherewerenosignificantdifferencesinFPV,FPA,RSPV,RSPA,HPVandHPAgroups.Afteradjustingconfoundingfactors,theregressioncoefficients(RC)wereestimatedasfollow:forFPV,femalegender(RC-0.21,P=0.02),triglyceride(RC-0.09,P<0.01),RVOT(RC0.03,P=0.02);forRSPV,femalegender(RC-0.21,P<0.01),triglyceride(RC-0.10,P<0.01),averageheartrate(RC0.01,P=0.02);forHPV,triglyceride(RC-0.08,P<0.001),LDL(RC-0.19,P<0.01),ApoB(RC0.67,P<0.01);forRSPA,Btypeofblood(RC-22.06,P=0.02),Cystatin-C(RC-72.79,P=0.02),thicknessofinterventricularseptum(RC3.70,P=0.01).Cystatin-CwassuggestedasacurerelatedtoRSPA,andthecut-offpointwas1.6mg/L.TherewerenosignificantriskfactorsassociatedwithFPAandHPA.TherewasnodifferenceinvirtualPvectoramongDM,IGTandNDMgroups.ConclusionIncreasedlevelsoflipidandCystatin-CsignificantlyimpactthecharacteristicsofvirtualPvector,whereasglucosedoesnot.Thesechangesmaycomefromahigherlowvoltageatrialareaandabnormalorientationofatrialdepolarization.

简介：瞄准：为了在streptozotocin(STZ)的阴囊的组织每氧化(LPO)和抗氧化剂酶的活动在类脂化合物上检验melatonin治疗的效果，导致了糖尿病的老鼠。方法：26只雄的老鼠随机如下被划分成三个组：组我，控制，非糖尿病的老鼠(n=9)；组II，导致STZ的、未经治疗的糖尿病的老鼠(n=8)；组III，导致STZ，对待melatonin(10mg/kg的剂量。白天)糖尿病的老鼠(n=9)。后面的8星期的melatonin处理，所有老鼠被使麻木然后被打死把睾丸从阴囊移开。结果：作为与组相比我，在老鼠组II的阴囊的纸巾，malondialdehyde(MDA)的增加的层次(P<0.01)并且超级氧化物歧化酶(草皮)(P<0.01)象过氧化氢酶(猫)的减少的层次一样(P<0.01)并且谷胱甘肽过氧化物酶(GSH-Px)(P>0.05)被发现。相反作为与组II相比，在老鼠组III的阴囊的纸巾，MDA的层次减少了(但是这减少不是重要的，P>0.05)并且草皮(P<0.01)象猫一样(P<0.05)增加。GSH-Px没被任何处理影响。Melatonin显著地没影响糖尿病的组的提高的葡萄糖集中。在学习的结束，借助于身体和阴囊的重量在对待melatonin的组和未经治疗的组之间没有有效差量。结论：糖尿病增加氧化应力，melatonin每氧化和力量禁止类脂化合物调整糖尿病的老鼠睾丸的抗氧化剂酶的活动。