简介：Anticancerimmunotherapyhasundergonealongevolvingjourneyfordecades,andhasbeendramaticallyappliedtomainstreamtreatmentsinoncologyinrecent5years.Thisprogressrepresentsanadvancedmilestonefollowingcytotoxicmedicineandtargetedtherapy.Cellularimmunityplaysapivotalroleintheimmuneresponsesofhoststotumorantigens.Suchimmunityisnotablysuppressedduringneoplasticprogressionduetoimmuno-editingprocesses.Cellularimmunitycanalsobeselectivelyreactivatedtocombatmalignancieswhileexploitingtheadvantagesofcontemporaryscientificbreakthroughsinmolecularimmunologyandgeneticengineering.Therapidadvancementofcellularimmunity-basedtherapeuticapproacheshasachievedhighefficacyincertaincancerpatients.Consequently,thelandscapeofoncologicmedicineandpharmaceuticalinnovationhastransformedrecently.Inthisregard,wepresentacomprehensiveupdateonclinicallyestablishedanti-cancertreatmentswithcellimmunityaugmentationasthemajormechanismofaction.

简介：Weintroducemultilevelaugmentationmethodsforsolvingoperatorequationsbasedondirectsumdecompositionsoftherangespaceoftheoperatorandthesolutionspaceoftheoperatorequationandamatrixsplittingscheme.Weestablishageneralsettingfortheanalysisofthesemethods,showingthatthemethodsyieldapproximatesolutionsofthesameconvergenceorderasthebestapproximationfromthesubspace.Theseaugmentationmethodsallowustodevelopfast,accurateandstablenonconventionalnumericalalgorithmsforsolvingoperatorequations.Inparticular,forsecondkindequations,specialsplittingtechniquesareproposedtodevelopsuchalgorithms.Thesealgorithmsarethenappliedtosolvethelinearsystemsresultingfrommatrixcompressionschemesusingwavelet-likefunctionsforsolvingFredholmintegralequationsofthesecondkind.Forthisspecialcase,acompleteanalysisforcomputationalcomplexityandconvergenceorderispresented.Numericalexamplesareincludedtodemonstratetheefficiencyandaccuracyofthemethods.IntheseexamplesweusetheproposedaugmentationmethodtosolvelargescalelinearsystemsresultingfromtherecentlydevelopedwaveletGalerkinmethodsandfastcollocationmethodsappliedtointegralequationsofthesecondkind.Ournumericalresultsconfirmthatthisaugmentationmethodisparticularlyefficientforsolvinglargescalelinearsystemsinducedfromwaveletcompressionschemes.

简介：DenotebyQmthegeneralizedquaterniongroupoforder4m.LetR（Qm）beitscomplexrepresentationring,andΔ（Qm）itsaugmentationideal.Inthispaper,theauthorgivesanexplicitZ-basisfortheΔn（Qm）anddeterminestheisomorphismclassofthen-thaugmentationquotientΔn（Qm）/(Δn+1（Qm）)foreachpositiveintegern.

简介：AnapproximationalgorithmispresentedforaugmentinganundirectedweightedgraphtoaK-edge-connectedgraph.Thealgorithmisusefulfordesigningareliablenetwork.

简介：为河环境的保存和恢复，一种沉积补充技术，它传送在水坝下面从水库挖掘或挖出到河的沉积的部分被开发并且在几个水坝尝试性地被实现了。作为补充放的沉积能外面被冲洗并且由洪水或水坝版本下游地搬运了。冲洗沉积被期望贡献降级和低流动的隧道的变化的控制。然而，因为有许多未知因素，这种技术在发展阶段。因此，系统的调查为这种技术的实际管理是必要的。在这研究，沉积涌出上并且在降级的控制上的补充沉积的地点的效果借助于斜槽实验被调查。一个二维的数字模型也被开发进一步在河恢复上调查沉积扩大的效果。数字模型享受在固定的床上存侵蚀和沉积运输。模拟结果对试验性的结果被验证。补充沉积的涌出的过程首先被调查，然后它的效果作为为河床降级的一项反措施被分析。结果如下被总结：(1)扩大在上面翻动为补充沉积和低流动的隧道的变化涌出是有效的。(2)降级的改善能在放置的二种类型的情况中被发现。改善效果上面翻动放置比的大更低翻动在固定的床上的补充地点附近的床的沉积率是的放置(3)在大更低翻动放置与相比上面翻动放置。(4)数字模型被发现作为一个预兆的工具通常成功。

简介：AbstractPurpose:Comminuted intraarticular distal radial fractures are difficult to treat conservatively and require operative treatment. This study compared the functional outcomes between variable angle volar plating and external fixator with K-wire augmentation in open reduction and internal fixation.Methods:A total of 62 adult patients with comminuted intraarticular distal radius fracture were randomized into 2 groups: volar plate group and external fixator group. These patients aged between 18 and 60 years had unilateral fractures, and agreed to be included in the study. Patients with a history of fracture, bilateral fracture, associated other injuries, delayed injury for more than 2 weeks, open fracture, pre-existing arthrosis or disability, psychiatric illness and pathological fracture were excluded. Patients were followed up at 6 weeks, 3 months, 6 months and 1 year. The assessment of pain, functional activity, range of motion and grip strength was done at each stage of follow-up. The pain and functional activities were assessed by patient rated wrist evaluation (PRWE) score and disabilities of the arm, shoulder and hand (DASH) score.Results:Patients in volar plate group had superior PRWE score and DASH score at each stage of follow-up. At 1 year follow-up, the mean PRWE score were 7.48 for volar plate group and 7.35 for external fixator group; while the mean DASH score was 4.65 for volar plate group and 5.61 for external fixator group. They had better flexion and extension range of movement. They also had better pronation and supination range of motion at initial follow-up, however the difference get attenuated by 1 year. Volar plate group had significantly better grip strength than external fixator group. Complication rates were higher in external fixation group.Conclusion:Fixation with variable angle volar plate results in early wrist mobilization, better range of movement, less pain and disability and early return of function.