简介：AIMToinvestigatetheinfluenceofprotonpumpinhibitors（PPIs）exposureonthediagnosisofHelicobacterpylori（H.pylori）gastritisandintestinalmetaplasia.METHODS：ChronicPPIuseisassociatedwithmaskingofH.pyloriinfection.PatientswithH.pyloriinfectionarepredisposedtogastricandduodenalulcers,andlong-terminfectionwiththisorganismhasbeenassociatedwithgastricmucosalatrophyandseriouslong-termcomplications,suchasgastriclymphomaandadenocarcinoma.ThreehundredpatientsdiagnosedwithgastritisbetweenJanuary2008andApril2010wereincludedinourstudy.Thecomputerizedmedicaldatabaseofthesepatientswasreviewedretrospectivelyinordertoassesswhetherthetypeofgastritisdiagnosed（H.pylorivsnon-H.pylorigastritis）isinfluencedbyPPIexposure.H.pyloridensitywasgradedaslow,ifcorrespondingtomilddensityfollowingtheUpdatedSydneySystem,orhigh,ifcorrespondingtomoderateorseveredensitiesintheUpdatedSydneySystem.RESULTS：Patientswereequallydistributedbetweenmalesandfemaleswithamedianageatthetimeofdiagnosisof50yearsold（range：20-87）.ThehistologicaltypesofgastritiswereclassifiedasH.pylorigastritis（n=156,52%）andnon-H.pylorigastritis（n=144,48%）.Allpatientswithnon-H.pylorigastritishadinactivechronicgastritis.PatientswithnopreviousPPIexposureweremorelikelytobediagnosedwithH.pylorigastritisthanthosewithpreviousPPIexposure（71%vs34.2%,P〈0.001）.Intestinalmetaplasiawasmorelikelytobedetectedinthelatterpatients（1.4%vs6.5%,P=0.023）.MultivariateanalysishasalsodemonstratedthatinthepresenceofpreviousPPIexposure（OR=0.217,95%CI：0.123-0.385）,GERD（OR=0.317,95%CI：0.132-0.763,P=0.01）,alcoholintake（OR=0.396,95%CI：0.195-0.804,P=0.01）,thedetectionofH.pyloriwaslesslikely.ChronicuseofPPIsmaymaskH.pyloriinfectionspromotingthediagnosisofnon-H.pylorigastritisandleadstoasi