简介：ObjectiveTorecordtheendocochlearpotential(EP)andcalculatepotassiumconcentration[K+]inMinipigcochleae.MethodsWeusedmulti-barreledelectrodestomeasuretheEPandthepotential,[K+].EPandpotassiumelectroderecordingweremadein9cochleaefrom5minipigstogetnormalEPvalues.ResultsTheaverageEPvalueinthecochleafromtheminipigswas77.3±14mV.Theaverage[K+]fortheminipigswas147.1±13mM.ConclusionsTheEPandpotential,[K+]inminipigsarelowerthaninthehumanandrodents.ThismaybethereasonwhyporcineABRthresholdsareslightlyhigherthanhumansandrodents.

简介：Minipigmodelsarelargemammalsandtheirearsaremoresimilarwithhumanbeingsinstructureanddevelopmentthanotheranimals.However,thestudyonporcineearsisstillintheinitialstageandthereisnodescriptionofanidealoperationapproachtoendocochlearpotentialandpotassiumionconcentrationmeasurements.Inthisarticle,wedescribeapre-auricularsurgicalapproachtoaccessthemiddleandinnerearforendocochlearpotentialandpotassiumionconcentrationmeasuresinminipigmodels.Tenone-weekoldnormalminipigswereusedinthestudy.Thebullaofthetemporalbonewasaccessedviaapre-auricularapproachforendocochlearpotentialandpotassiumionconcentrationmeasurements.Theconditionoftheanimalsduringthefirstpost—experiment24hwasobserved.Oneanimaldiedduringsurgery.Thepreauricularapproachimprovedprotectionandpreservationofrelevantnervousandvascularelementsincludingthefacialnerveandcarotidartery.So,thepre-auricularapproachcanbeusedforendocochlearpotentialandpotassiumionconcentrationmeasurementswithimprovednerveandarterypreservationminipigs.