学科分类
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1 个结果
  • 简介:TelomeraseisanenzymethatmaintainstelomeresindividingcellsusingatemplateonitsinherentRNAcomponent.Additionally,theproteinpartTERT(TelomeraseReverseTranscriptase)hasvariousnon-canonicalfunctions.Forexample,itcanlocalizetomitochondriaunderincreasedstressandprotectcellsinvitrofromoxidativestress,DNAdamageandapoptosis.RecentlyithasbeendemonstratedthatTERTproteinpersistsinadultneuronsinthebrainanddataemergesuggestingthatitmighthaveaprotectivefunctioninthesepost-mitoticcellsaswell.WehaverecentlypublishedthatTERTproteinaccumulatedinmitochondriafrombraintissueofmicethathaveundergoneshort-termdietaryrestriction(DR)andrapamycintreatment.Thislocalizationcorrelatedtolowerlevelsofoxidativestressinthesebrainmitochondria.SincerapamycintreatmentdecreasesmTORsignalingwhichisalsothoughttoplayanimportantroleforthebeneficialeffectsofDR,weconcludethatthemTORpathwaymightbeinvolvedintheTERTlocalizationanditseffectsinbrainmitochondriainvivo.ThesedataareinlinewithpreviousfindingsfromourgroupaboutincreasedmitochondriallocalizationofTERTinAlzheimer'sdisease(AD)brainsandaprotectivefunctionofTERTproteininneuronsinvitroagainstpathologicaltau.

  • 标签: 端粒酶逆转录酶 MTOR 线粒体 大脑 连接 细胞分裂