简介：TherelationshipsbetweenthepropertiesofPVC-MBSpolyblendandoftheMBSmultiphasestructureandbetweentheMBSstructureandpolymerizationparametersarestudiedtheoreticallyandexperimentally.MBSresinsynthesizedfromthemoleculedesignprincipleissuitabletopreparePVC-MBSpolyblendwithgoodtransparencyandhighimpactstrength.

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简介：控制并且操作单个fluorophores的荧光具有对为它在改进分子的photonics和分子的电子学的表演的潜在的使用的最近的年的大兴趣，例如在基于单个分子的器官的轻射出的设备，单个光子来源，器官的地效果晶体管，和探针或传感器。这评论显示出单个器官的分子的荧光排放怎么能用金属性的nanostructures和electric-field-induced电子转移的本地电磁的领域被修改。荧光开关的Electric-field-induced荧光调整，磁滞现象，和成就详细被讨论。

简介：Moleculardynamics(MD)simulationsareperformedtostudyadhesionandpeelingofashortfragmentofsinglestrandDNA(ssDNA)moleculefromagraphitesurface.Thecriticalpeel-offforceisfoundtodependonboththepeelingangleandtheelasticityofssDNA.FortheshortssDNAstrandunderinvestigation,weshowthatthesimulationresultscanbeexplainedbyacontinuummodelofanadhesiveelasticbandonsubstrate.Theanalysissuggeststhatitisoftenthepeakvalue,ratherthanthemeanvalue,ofadhesionenergywhichdeterminesthepeelingofananoscalematerial.

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简介：Apoptosis在众多的医药混乱的病原学或致病起一个枢轴的作用，并且这样，apoptotic房间指向可以实质地推进耐心的照顾。在我们为为apoptosis的新奇low-molecular-weight探针的探索，我们集中了于不平常的氨基酸纬-carboxyglutamic酸(Gla)，它在clotting因素的绑定起一个重要作用到否定地控告的phospholipid表面。基于Gla的alkyl-malonic酸主题，我们开发了并且现在介绍ML-10(2-(5-fluoro-pentyl)-2-methyl-malonic酸，MW=206Da)，apoptosis的小分子的察觉者的一个新奇家庭的原型的成员。ML-10被发现在apoptotic房间执行选择举起和累积，当从可行或坏死的房间被排除时。有caspase激活，Annexin-V绑定和mitochondrial膜潜力的混乱的apoptotic特点的ML-10举起相互关联。malonate一半被发现为在apoptosis察觉的ML-10功能关键。ML-10在早apoptosis对房间的特征的唯一的建筑群作出回应，包括膜潜力，房间膜和细胞质的永久使发酸，和膜正直的保藏的不可逆的损失。ML-10因此是迄今为止知道的最紧缩的apoptosis探查。由于它的氟的符号原子，ML-10对顺从与18F同位素标记收音机，向它为apoptosis的临床的正电子排放断层摄影术成像的潜在的未来使用。

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简介：IntroductionMoleculeimprintingtechnologyhasmadegreatprogressinmakingchiralstationaryphasewithpredeterminedchiralselectivityagainstenantiomerssuchasaminoacidandtheirderivatives;sugarandtheirderivatives;naproxenandmethylbenZylamine’-’.Functionalmonomer...

简介：Theanisotropicpotentialdevelopedinourpreviousresearchandtheclose-couplingmethodareappliedtotheHBr-3He(4He,5He,6He,7He)system,andthepartialcrosssections(PCSs)attheincidentenergyof60meVarecalculated.Basedonthecalculations,theinfluencesoftheisotopeheliumatomonPCSsarediscussedindetail.TheresultsshowthattheexcitationPCSsconvergefasterthantheelasticPCSsforthecollisionenergyandthesystemsconsideredhere.AlsotheexcitationPCSsconvergemorerapidlyforthehigh-excitedstates.Thetaileffectispresentonlyinelasticscatteringandlow-excitedstatesbutnotinhigh-excitedstates.Withtheincreaseofreducedmassofthecollisionsystem,theconvergingspeedoftheelasticandexcitationPCSsslowsdown,andthetaileffectgoesup.

简介：Theeffectsofthemagneticfieldonthevalencebondpropertyofthedouble-quantum-dotmoleculearenumericallystudiedbythefiniteelementmethodandperturbationapproachbecauseoftheabsenceofcylindricalsymmetryinthehorizontallycoupleddots.Thecalculationresultsshowthattheenergyvalueofthegroundstatechangesdifferentlyfromthatofthefirstexcitedstatewithincreasingmagneticfieldstrength,andtheycrossunderacertainmagneticfield.Theincreasingmagneticfieldmakesthecovalentbondstatechangeintoanionicbondstate,whichagreesqualitativelywithexperimentalresultsandandmakesionicbondstatesremain.Theoscillatorstrengthoftransitionbetweencovalentbondstatesdecreasesdistinctlywiththeincreasingmagneticfieldstrength,whenthemoleculeisirradiatedbypolarizedlight.Suchaphenomenonispossiblyusefulforactualapplications.

简介：Weproposeanewmeasurementschemefortheatom-moleculedarkstatebyusingelectromagneticallyinducedtransparency(EIT)technique.Basedonadensity-matrixformalism,wecalculatetheabsorptioncoefficientnumerically.TheappearanceoftheEITdipinthespectraprofilegivesclearevidenceforthecreationofthedarkstateintheatom-moleculeBose-Einsteincondensate.

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简介：我们采用nonequilibrium格林的函数方法理论上在一个使变形的分子学习Kondo效果，它被当作一个电子声子相互作用(EPI)系统。为声子部分的自我精力在标准许多身体被计算图解的扩大直到在EPI力量的第二份订单。我们发现多重帮助声子的Kondo卫星除平常的Kondo回声以外产生。在反平行的磁性的配置切开主要Kondo山峰和帮助声子的卫星仅仅发生因为不均匀的点铅couplings，而是它从为平行磁性的配置的对称是免费的。EPI力量和震动的频率能提高主要Kondo和卫星切开的旋转。压制的零偏爱的Kondo回声能被使用一个外部磁场恢复，这被显示出，其大小显著地依赖于phononic效果。尽管在隧道联合的不对称现象没有贡献到Kondo山峰切开的纺纱的恢复，它能缩小需要交换在大否定剧降和大积极山峰之间的通道磁致电阻比率的外部地。

简介：AbstractBackground:Pulmonary fibrosis is a respiratory disease caused by the proliferation of fibroblasts and accumulation of the extracellular matrix (ECM). It is known that the lung ECM is mainly composed of a three-dimensional fiber mesh filled with various high-molecular-weight proteins. However, the small-molecular-weight proteins in the lung ECM and their differences between normal and fibrotic lung ECM are largely unknown.Methods:Healthy adult male Sprague-Dawley rats (Rattus norvegicus) weighing about 150 to 200 g were randomly divided into three groups using random number table: A, B, and C and each group contained five rats. The rats in Group A were administered a single intragastric (i.g.) dose of 500 μL of saline as control, and those in Groups B and C were administered a single i.g. dose of paraquat (PQ) dissolved in 500 μL of saline (20 mg/kg). After 2 weeks, the lungs of rats in Group B were harvested for histological observation, preparation of de-cellularized lung scaffolds, and proteomic analysis for small-molecular-weight proteins, and similar procedures were performed on Group C and A after 4 weeks. The differentially expressed small-molecular-weight proteins (DESMPs) between different groups and the subcellular locations were analyzed.Results:Of the 1626 small-molecular-weight proteins identified, 1047 were quantifiable. There were 97 up-regulated and 45 downregulated proteins in B vs. A, 274 up-regulated and 31 down-regulated proteins in C vs. A, and 237 up-regulated and 28 downregulated proteins identified in C vs. B. Both the up-regulated and down-regulated proteins in the three comparisons were mainly distributed in single-organism processes and cellular processes within biological process, cell and organelle within cellular component, and binding within molecular function. Further, more up-regulated than down-regulated proteins were identified in most sub-cellular locations. The interactions of DESMPs identified in extracellular location in all comparisons showed that serum albumin (Alb) harbored the highest degree of node (25), followed by prolyl 4-hydroxylase beta polypeptide (12), integrin β1 (10), apolipoprotein A1 (9), and fibrinogen gamma chain (9).Conclusions:Numerous PQ-induced DESMPs were identified in de-cellularized lungs of rats by high throughput proteomics analysis. The DESMPs between the control and treatment groups showed diversity in molecular functions, biological processes, and pathways. In addition, the interactions of extracellular DESMPs suggested that the extracellular proteins Alb, Itgb1, Apoa1, P4hb, and Fgg in ECM could be potentially used as biomarker candidates for pulmonary fibrosis. These results provided useful information and new insights regarding pulmonary fibrosis.

简介：IntheHL-1Mplasmaexperiments,tworefuelingways,thepelletinjectionandthegaspuffing,areusuallyused.Inrecentyears,anewrefuelingmethod,thesupersonicmoleculebeam(SMB)injection,hasbeendeveloped.SMBinjectionisanattempttoenhancethepenetrationdepthandthefuellingefficiencyofgas,aswellastoreducesurfaceabsorptionoftheinjectedparticlesandtheimpuritycontentintheplasma.InSMBinjectionexperiments,thegasisinjectedintotheplasmathroughaLavalnozzleathighgaspressure.Inthiscase,thepeakdensityandimprovingconfinementhavebeenachievedasinthecaseofapelletinjection.

简介：Rareattentionhasbeenpaidtothecomparisonbetweenamonomeranditscorrespondingpolymerintermsoftheoptoelectroniccharacteristics.Inthisarticle,amodelH-shapedmoleculeanditscorrespondingpolymer,bothofwhichexhibitedsimilarpropertiesincludingblueemissionandsolutionprocessing,weredesignedandsynthesized.Optoelectronicpropertiesandvariouskindsofstabilityfeatures,includingthethermostabilities,spectralstabilitiesandamplifiedspontaneousemissioncharacteristicofthemonomerandpolymerwereinvestigated.Ingeneral,thecorrespondingpolymerPHexhibitedsimilaroptoelectronicpropertiesbutdeterioratedstabilitiescomparedwithitsH-shapedmonomerH-1probablyowingtothesimilarchemicalstructurebutthewidermolecularweightdistributionandmetalcatalystresidue.Importantly,monomerH-1displayedacomparableASEthresholdvaluewithitspolymerPH,suggestingthatH-shapedfluorene-basedsmallmoleculesmaybemorepromisingopticalgainmediainsolidstateamplifersandlasers.