简介：Thisreviewbeginswithabriefcommentaryonthediversityofplacentationmechanisms,andthengoesontoexaminetheextensivealterationswhichoccurintheplasmamembraneofuterineepithelialcellsduringearlypregnancyacrossspecies.Ultrastructural,biochemicalandmoregeneralmorphologicaldatarevealthatstrikinglycommonphenomenaoccurinthisplasmamembraneduringearlypregnancydespitethediversityofplacentaltypes-fromepitheliochorialtohemochorial,whichultimatelyformindifferentspecies.Toencapsulatetheconceptthatcommonmorphologicalandmolecularalterationsoccuracrossspecies,thattheyarefoundbasolaterallyaswellasapically,andthatmoreovertheyareanongoingprocessduringmuchofearlypregnancy,notjustaneventatthetimeattachment,braneduringearlypregnancyarekeytouterinereceptivity.

简介：AbstractNormal pregnancy is associated with dramatically increased estrogen biosynthesis whose role is believed to raise uterine blood flow to facilitate the bi-directional maternal-fetal exchanges of gases (O2 and CO2), to deliver nutrients, and exhaust wastes to support fetal development and survival. Constrained uterine blood flow in pregnancy is a leading cause of preeclampsia with fetal growth restriction, rendering investigations of uterine hemodynamics to hold a high promise to inform pathways as targets for therapeutic interventions for preeclampsia. The mechanisms of estrogen-induced uterine vasodilation in pregnancy have long been attributed to enhanced endothelium production of nitric oxide, but clinical trials targeting this pathway that dominates uterine hemodynamics have achieved no to little success. Emerging evidence has recently shown a novel proangiogenic vasodilatory role of hydrogen sulfide in regulating uterine hemodynamics in pregnancy and preeclampsia, provoking a new field of perinatal research in searching for alternative pathways for pregnancy disorders especially preeclampsia and intrauterine growth restriction. This minireview is intended to summarize the nitric oxide pathway and to discuss the emerging hydrogen sulfide pathway in modulating estrogen-induced uterine vasodilation in pregnancy and preeclampsia.

简介：Thisisareportofanonrandomizedcomparisonoftreatmentresultsof139patientswithstageIB,HAandproximalIIBcarcinomaoftheuterinecervixtreatedbyradiationaloneand113treatedwithacombinationofradiationandsurgery.Thefive-yeartumorfreeacturialsurvivalforthepatientswithstageIBeitherwithirradiationalone(RT)orcombinedwithsurgery(RS)wasapproximately87%.ForstageⅡthetumorfreeactuarialfive-yearsurvival79%withpatientsofRS,and76%withRT.Inthe113patientstreatedwithRStherewere18(16%).Inthe139patientstreatedbyRTtherewere18(13%)recurrencesofpelvic,4localrecurrences,11combinedwithparametrial,andfreeparametrialrecurrences.Therewasnosignificantdifferenceinthesurvivalandrecurrencerateofthepatientstreatedwitheithermethod.Majorcomplicationswerecomparableinbothgroups(RTapproximately25%andRSapproximately10%),but2/3ofthosecomplicationsrecoveredwithoutsequelae.Themostfrequentminor

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简介：Theuterinetetaniccontractionanduterinearterybloodflowreductionarepossiblereasonsforprimarydysmenorrhea（PD）.Inthepresentstudy,weaimedtoevaluatetheuterinerelaxanteffectandtheinfluenceonuterinearterybloodvelocityofGe-GenDecoction（GGD）,awell-knownChineseherbalformula.InfemaleICRmice,uterinecontractionwasinducedbyoxytocinexposurefollowingestradiolbenzoatepretreatment,andtheuterinearterybloodvelocitywasdetectedbyDopplerultrasound.HistopathologicalexaminationoftheuterinetissuesampleswereperformedbyH&Estaining.Exvivostudiesdemonstratedthatoxytocin,posteriorpituitary,oracetylcholineinducedcontractionsinisolatedmouseuterus.GGDinhibitedbothspontaneousandstimulatedcontractions.InvivostudydemonstratedthatGGDsignificantlyreducedoxytocin-inducedwrithingresponseswithamaximalinhibitionof87%.FurtherstudydemonstratedthatGGDnormalizedoxytocin-inducedabnormalitiesofprostaglandinsF2alpha(PGF2α)andCa2+inmice.Inaddition,injectionofoxytocininducedadecreaseinuterinearterybloodflowvelocity.PretreatmentwithGGDreversedtheoxytocinresponseonbloodflowvelocity.HistopathologicalexaminationshowedpretreatmentwithGGDalleviatedinflammationandedemaintheuteruswhencomparedwiththemodelgroup.BothexvivoandinvivoresultsindicatedthatGGDpossessedasignificantspasmolyticeffectonuterinetetaniccontractionaswellasimprovementonuterinearterybloodvelocitywhichmayinvolvePGF2αandCa2+signaling,suggestingthatGGDmayhaveaclinicpotentialinPDtherapy.

简介：生来的杀手(NK)房间是骨头导出髓的淋巴细胞。他们生产cytokines调整获得的免疫的发展。鉴于他们在母亲胎儿的接口的累积，子宫的生来的杀手(uNK)房间也被认为在怀孕期间起必要作用。我们的结果在子宫的子宫内膜，肝，怒气和外部血由NK房间比较了cytokine分泌物侧面的差别，并且由uNK房间集中了于cytokines分泌物。在怀孕鼠标的子宫的子宫内膜的IFN-和TNF-的表达式是比在肝的那些低的，这被表明，但是他们在怀孕期间显著地增加。我们的学习证明uNK房间的数字在怀孕期间显著地被增加。他们比另外的导出器官的NK房间，和他们也分泌IL-4和IL-5的次要的数量的生产了更多的IFN-和TNF-。结果显示uNK房间生产的IFN-和TNF-保证了成功的怀孕进步。