简介:糖尿病视网膜病变(DR)是作为一种常见的糖尿病并发症,对其发病机制的研究一直是关注的焦点。经典的糖尿病视网膜病变的发病机制假说集中与多元醇通路的异常、蛋白质非酶糖基化产物的堆积、蛋白激酶C及氨基己糖途径有关。聚腺苷二磷酸核糖聚合酶(PARP)作为统一机制中的一个关键分子,与DR发病机制及其防治密不可分,对其进行适当干预,可成为DR治疗的重要方法之一。
简介:目的:探讨超声乳化术治疗特殊类型白内障的安全性和有效性。方法:回顾性分析临床资料,研究超声乳化吸出(联合)人工晶状体植入术治疗青光眼术后白内障、小瞳孔白内障、葡萄膜炎并发白内障和外伤后并发白内障等特殊类型白内障的技术要领。结果:进行治疗的73例84眼特殊类型白内障患者中,单纯行超声乳化术27例28眼,植入后房型人工晶状体52眼,植入前房型人工晶状体4眼;术后1mo平均眼压12.72±2.63mmHg,脱盲率99%,脱残率96%;并发症发生率4%。结论:特殊类型白内障手术难度大,超声乳化术切口小,可保留晶状体后囊膜和植入人工晶状体,是摘除特殊类型白内障的理想术式。
简介:AIM:Toevaluatetheefficacyofintralesionalradiofrequencyablationinthetreatmentofperiorbitalsyringomas.·METHODS:Wetriedtheintralesionalradiofrequencyablationfor64patientswithperiorbitalsyringomasfrom2007to2011.Theoperationwasperformedunder2.5loupemagnifications.Thehandpiecewasassembledwithaneedleelectrodeandconnectedtotheradiofrequencyablationapparatus.Theelectrodewastheninsertedintothetargetlesionsindermisanddeliveringinjurytothebaseofthesetumors.Resultswereassessedclinicallybycomparingpre-andpost-treatmentphotographsandpatientsatisfactionrates.·RESULTS:Clinicalimprovementincreasedwitheachsubsequenttreatmentsession.Thepercentofpatientswhoseclinicimprovementgradewere≥3aftereachsessionwasrespectively71.9%(Session1),83.3%(Session2),and100%(Session3).Thestatisticalresultsindicatedtheconcordanceoftheclinicalassessmentandthesatisfactionlevelofpatients(kappa=0.78ofthesession1;kappa=0.82ofthesession2).Themajorityofpatientshadgoodorexcellentcosmeticresults.Postoperatively,therewerenopermanentsideeffectsorrecurrences.·CONCLUSION:Asanewtechniqueofminimallyinvasion,theintralesionalradiofrequencyablationwasfoundtobeaneffective,inexpensive,highlypreciseandsafewayoftreatingperiorbitalsyringomas.