学科分类
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2 个结果
  • 简介:Colorectalcancer(CRC)isthethirdmostcommoncancerdiagnosedworldwideinhumanbeings.Surgery,chemotherapy,radiotherapyandtargetedtherapiesaretheconventionalfourapproacheswhicharecurrentlyusedforthetreatmentofCRC.Thesitespecificdeliveryofchemotherapeuticstotheirsiteofactionwouldincreaseeffectivenesswithreducingsideeffects.Targetedoraldrugdeliverysystemsbasedonpolysaccharidesarebeinginvestigatedtotargetanddeliverchemotherapeuticandchemopreventiveagentsdirectlytocolonandrectum.Site-specificdrugdeliverytocolonincreasesitsconcentrationatthetargetsite,andthusrequiresalowerdoseandhenceabridgedsideeffects.Somenoveltherapiesarealsobrieflydiscussedinarticlesuchasreceptor(epidermalgrowthfactorreceptor,folatereceptor,wheatgermagglutinin,VEGFreceptor,hyaluronicacidreceptor)basedtargetingtherapy;colontargetedproapoptoticanticancerdrugdeliverysystem,genetherapy.EventhoughgoodtreatmentoptionsareavailableforCRC,theultimatetherapeuticapproachistoaverttheincidenceofCRC.ItwasalsofoundthatCRCscouldbepreventedbydietandnutritionsuchascalcium,vitaminD,curcumin,quercetinandfishoilsupplements.ImmunotherapyandvaccinationareusednowadayswhichareshowingbetterresultsagainstCRC.

  • 标签: COLORECTAL cancer RECEPTOR based targetedtherapy GENE
  • 简介:瞄准:学习颜色的协会有侵略的癌,本地复发,synchronicity和损害的元慢性的表面的锯齿状腺瘤(SA)。方法:从在一个八年的时期(1987-1995)上的1,096个病人的4,536息肉的一个总数回顾地被检验。显示出至少50%serrated建筑学的腺瘤被三称为SA考察病理学家。结果:(2%)91所有息肉被称为SA,它在46个病人被发现。侵略的癌从46在3被看见(6.4%)病人,一个人是家庭腺瘤息肉病(FAP)的一个盒子。男优势被注意,发育异常的温和的度的特征在多数被看见(n=75,83%)锯齿状腺瘤。后续变化了有5.75年的一吝啬的时间的1-12年。SA的复发在3被看见(6.4%)盒子,在16的同步SA(34.8%)在9的盒子和异时SA(19.6%)盒子。结论:侵略的癌在锯齿状腺瘤产生是稀罕的,为2的财务(4.3%)在这个系列的casesstudied。

  • 标签: 结直肠肿瘤 病理学视觉 病理机制 临床