简介:摘 要:随着信息技术的不断发展,5G技术获得了较为广泛的应用,促进了广播技术的不断发展。本文对5G广播技术进行了一定的论述,分别从网络架构、帧结构和参数集、无线发射系统以及业务承载能力等方面进行了分析,有助于促进5G广播技术在更大的范围内进行推广应用,对于从事相关工作的技术人员具有一定的借鉴意义。
简介:AbstractBackground:The elimination of Plasmodium vivax malaria requires 8-aminoquinolines, which are contraindicated in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to the risk of acute haemolytic anaemia. Several point-of-care devices have been developed to detect G6PD deficiency. The objective of the present study was to evaluate the performance of two of these devices against G6PD genotypes in Mauritania.Methods:Outpatients were screened for G6PD deficiency using CareStart™ rapid diagnostic test (RDT) and CareStart™ G6PD biosensor in Nouakchott, Mauritania, in 2019-2020. African-type and Mediterranean-type G6PD genotypes commonly observed in Africa were determined by polymerase chain reaction-restriction fragment length polymorphism and sequencing. Qualitative variables were compared using Fisher’s exact test.Results:Of 323 patients (74 males and 249 females), 5 males and 2 homozygous females had the African-type A-genotype: A-(202) in 3 males and 2 females and G6PD A-(968) in 2 males. Among heterozygous females, 13 carried G6PD A-(202), 12 G6PD A-(968), and 3 G6PD A-(542) variants. None had the Mediterranean-type G6PD genotype. Eight had a positive G6PD RDT result, including all 7 hemizygous males and homozygous females with A- or A-A- (0.12 to 2.34 IU/g haemoglobin, according to G6PD biosensor), but RDT performed poorly (sensitivity, 11.1% at the cutoff level of < 30%) and yielded many false negative tests. Thirty-seven (50.0%) males and 141 (56.6%) females were anaemic. The adjusted median values of G6PD activity were 5.72 and 5.34 IU/g haemoglobin in non-anaemic males (n = 35) and non-anaemic males and females (n = 130) with normal G6PD genotypes using G6PD biosensor, respectively. Based on the adjusted median of 5.34 IU/g haemoglobin, the performance of G6PD biosensor against genotyping was as follows: at 30% cut-off, the sensitivity and specificity were 85.7% and 91.7%, respectively, and at 80% cut-off, the sensitivity was 100% while the specificity was 64.9%.Conclusions:Although this pilot study supports the utility of biosensor to screen for G6PD deficiency in patients, further investigation in parallel with spectrophotometry is required to promote and validate a more extensive use of this point-of-care device in areas where P. vivax is highly prevalent in Mauritania.
简介:学校变革是教育改革的突破口与落脚点。大学与中小学在政府的支持保障或促成下进行合作的U-G-S模式具有重要意义,然而其局限也很明显:投入多、见效慢,理论研究者与实践者交流不畅。U-G-S-S模式承继了U-G-S模式的优势,并进行了突破:强调参与学校变革行动的中小学的数量为两所及以上,且学校教育质量是异质的,既有城市优质学校,也有城郊薄弱学校或乡村学校;U-G-S-S四方主体平等互动、各司其职。个案研究表明,U-G-S-S模式可以通过制度建构、任务驱动和文化营造促进各参与学校的整体发展,促进城乡义务教育均衡发展。U-G-S-S模式成功的三个主要要素:文化异质交融、知识多维共享、理论实践有机结合。