简介：Inordertoimprovethecompressivestrengthofxonotlite,thepretreatedquartzpowder,slakedCaO,additive,deionizedwater(water-solidratioof30)wereplacedinamagneticallystirredautoclave,andthecorrespondingproductswereobtainedafterincubatingat220℃for0,1,3and6h,respectivelytoexplorethesyntheticprocessofxonotlite.Inthepreparedxonotlitepowder,0,5%,10%,15%and20%(bymass,thesamehereinafter)ofpre-treatedceramicstaplefiberswereadded,andtwosetsofspecimenwiththespecificationsofφ50mm×35mmweremoldedbypressedfiltration.Onesetofspecimenswerenotsintered,andtheothergroupwasfiredat1000℃for2htoexploretheeffectofceramicfiberadditiononthecompressivestrengthbeforeandaftersinteringofxonotlite.TheresultsshowthatC-S-Hgelisfirstsynthesizedinthesynthesisofxonotlite,andthentheC-S-Hgelistransformedtoformtobermlite,atlasttobermlitefullyreactstoproducexonotlite.Theadditionofceramicfiberenhancesthecompressivestrengthofthexonotlitebeforeandaftersintering.Whenthe15%ceramicfiberisadded,thecompressivestrengthisthehighest.Thespecimensbeforeandafterthehightemperaturefiringcontainxonotlitephaseandcalciumsilicatephase,respectively,andthecompressivestrengthofthefiredspecimensishigherthanthatofthegreenones.

简介：Asworldconsumptionofenergygrowsfast,theprovenpetroleumreservesarelimitedintoday'sworld,andtheoilpricefluctuatesandmostoftensoarsupsharply,energyhasbecomeamostcrucialfactorintheworldeconomyandtheenergysecurity

简介：Inrecentyears,aconsiderableamountofmicroscopicspheruleshavebeenfoundinconcentratesrecoveredfromsomestrataboundgolddepositsoccurringinMiddle-UpperTriassicturbiditeseriesinnorthwesternSichuan.Studyindicatesthatthesespherulesarecosmicdust.ItisthefirsttimethatcosmicdustofextraterrestrialoriginhasbeenfoundinhydrothermalgolddepositsinChina.Thespherulesaresteel-greyincolourandshowmetallicluster.Theirgrainsizeiscommonlylessthan100μm.Accordingtotheircomposition,theybelongtochromium-richironcosmicdust.Thespheruleshavecomplexanddiversemicroscopicstructuresandtextures,i.e.theyshowaverydistinctWidmanstatenstructure.Thevariationofcosmicdustcontentingolddepositsexhibitsapositivecorrelationwiththemineralizationintensitiesandhydrothermalalteration.Sucharelationindicatesthattheoresub-stancesmaytransportnotonlymechanicallybutalsomaychemicallyinhydrothermalsolutions.

简介：LanddegradationisoneofthesignificantenvironmentalproblemsinbothChinaandCanada,whichseriouslythreatensthesustainabledevelopmentofnationaleconomyandsocietyofbothcountries.Thispaperintroducedsomepolicies,regulationsanddepartmentcoordinationmechanismsoflandresourcemanagement,restoration/rehabilitationofdegradedland,forestresourcesmanagement,agriculturalenvironmentalprotectionandmineralarealandreclamationinCanada.Somepractices,experiencesandeffectsinlanddegradationcontrolofCanadawerelistedandanalyzed.Finally,itwassuggestedthatthesuccessfulexperiencesofCanadaintechnology,policyandmanagementforlanddegradationcontrolshouldbelearnedforimprovingefficiencyoflanddegradationinChina’swesternregion.

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简介：Bonedefectisoneofthemostcommondiseasesinclinic.Existingtherapeuticapproacheshaveencounteredmanyproblems,suchaslackofautogenousallogeneicboneandimmunologicalrejectiontoallogeneicimplant.Synthetichydroxyapatite（HA）providedsolutionsforbonerepair,sincetheHAisthemaininorganiccomponentofanimals＇bone.AlthoughHAhasgoodbiocompatibility,butonlythelimitedosteogeniccapability,whichisofsignificanceformodernbonerepairmaterials.Siisanessentialtraceelementinbonetissue,andithasbeendemonstratedtobeabletopromoteboneformation.Therefore,silicate-dopedhydroxyapatite（Si-HA）mayserveasapromisingmaterialforbonerepair,andpromoteboneregenerationintherepair.ThecurrentreviewdiscussesdevelopmentofSi-HA,focusingonitspreparationandcharacterization,invitroandinvivoevaluationsofthematerial,positiveeffectofSi-HAonpromotingboneformationinclinicalapplications,andmolecularmechanisminvestigationofsuchpromotiveeffect.

简介：钴hexacyanoferrate(CoHCF)nanoparticle(尺寸ca。60nm)化学上修改的电极(CME)被制作，在这nanosizedCoHCFCME的血红素(Hb)的电气化学的行为被学习。与一个赤裸的玻璃质的碳电极(GCE)和以一种传统的方式的一般CoHCFCMEelectrodeposited比较，现在的nanosizedCoHCFCME高效地与相对高的敏感，稳定性，和longlife为Hb执行了electrocatalytic减小。与液体层析(LC)结合了，nanosizedCoHCFCME在确定的流动注射被用作Hb的电气化学的察觉者分析电气化学的决心(FIA-ECD)系统。山峰水流是在从2.5楳?景映牯業?捡摩映潲?慣'R湯搠潩楸敤愠摮栠摹潲敧?獵湩?的范围的集中的线性功能?楳楬慣椠浭扯汩穩摥爠瑵敨楮浵挠瑡污獹?獡瀠敲畣獲牯栠獡戠敥?瑳摵敩?湩搠晩敦敲瑮爠慥瑣潩?潣摮瑩潩獮?桔?敲?瑬?敲敶污摥琠慨?桴?佔?琨牵?癯牥映敲畱湥祣?景?佃?愠档敩敶????栠?漠?浩潭楢楬敺?畲桴湥畩?慣慴祬瑳渠慥?桴?牣瑩捩污瀠敲獳牵?潰湩?景??眠瑩??瀠敲獳牵?景???慐?敲捡楴湯琠浥数慲畴敲漠吗？？？？

简介：Objective:ToconfirmwhetherBungarusmulticinctuscrudevenominducestheapoptosisofK562tumorcellsandtofindoutthecomponentsinducingapoptosisofK562cellsfromthecrudevenom.Methods:thecrudevenomseparatedandpurifiedbycationexchangechromatography,andtheeffectofvenomsonK562wasstudiedbyMTTmethodandflowcytometry.Results:ThecrudevenombegantokillK562cellsatthan8(103ng/ml(thesurvivalratewas82.5%)concentrationandtheeffectwasmoresignificantin24hwhenadministrating8(105ng/ml(thesurvivalratewas29.4%)crudevenom.ApoptoticbodieswereobservedintheK562tumorcellsbyfluorescentmicroscopyafteradministrationof5(g/mlcycloheximide(CHX)orthepeakVIsolutionatabout8(105ng/ml.Thesameresultsweredetectedbytheflowcytometry.Asub-G1peakappearedafteradministrationofCHXorthesixthpeaksolution.Conclusion:TheauthorsfoundthatthevenomcankillK562tumorcellsintime-anddose-dependentmanner.However,thekillingeffectofthevenomisnotapoptosis.What'smore,thepeakVIsolution,acomponentofthecrudevenomcaninducetheapoptosisofK562tumorcells.

简介：这篇论文研究平板波导然后匹配的效率在之间的结束衍射远地并且它的Gaussian近似的地被分析导致分叉一半角度的一个新定义。最后，远地的罐头为什么被Gaussian功能接近，根据横梁繁殖因素的特征被介绍。

简介：SpatialscanningisdonefortworegionsinChineseMainland,wheredisplayedadenseprecursorynetworkduring1994～1998.Thetworegionsarethemid-southernsegmentoftheNorth-southseismicbelt(20°～35°N,95°～110°E)andNorthChina(36°～42°N,110°～120°E).Wetook0.5°×0.5°asaspatialwindowwithastepof0.25°and4monthsasatemporalwindowwithastepof1month.Forthetworegions,theanomalydensityisscannedfrom1994and1995respectivelyinthetworegions.TheprecursoryanomaliesareallfromtheDivisionofSeismicTrendinChinaandtheDivisionofSeismicTrendintheCapitalArea,CenterforAnalysisandPrediction,ChinaSeismologicalBureau.Aseismogenictectonicmodelisintroducedtoexplainthescanningresults.Inthemodel,thefrictionalstrengthofthefocalsourcesisdistributedrandomly.Aftertheboundaryplatemotionrateandallothergeologicalparametersaregiven,thestressofthesourcesinthesystemchangesinhomogenouslyduetothevariationofthefrictionalstreng

简介：Thepaperelaboratesindetailscertificationmechanismforsustainableforestmanagement,includingthedefinition,contents,objectives,costs,benefits,characteristics,proceduresandimpactsofcertificationaswellasmaincertificationsystems.ItalsointroducesindetailsthelatestprogressanddevelopmentperspectivesofcertificationinChinaandaroundtheworld.Certificationisamarket-basedmechanism,whichaimsatenhancingandstrengtheningthereasonableutilizationofforests.Itusua...

简介：AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve, generating new variants that pose a threat to global health; therefore, it is imperative to obtain safe and broad-spectrum antivirals against SARS-CoV-2 and its variants. To this end, we screened compounds for their ability to inhibit viral entry, which is a critical step in virus infection. Twenty compounds that have been previously reported to inhibit SARS-CoV-2 replication were tested by using pseudoviruses containing the spike protein from the original strain (SARS-CoV-2-WH01). The cytotoxicity of these compounds was determined. Furthermore, we identified six compounds with strong antagonistic activity against the WH01 pseudovirus, and low cytotoxicity was identified. These compounds were then evaluated for their efficacy against pseudoviruses expressing the spike protein from B.1.617.2 (Delta) and B.1.1.529 (Omicron), the two most prevalent circulating strains. These assays demonstrated that two phenothiazine compounds, trifluoperazine 2HCl and thioridazine HCl, inhibit the infection of Delta and Omicron pseudoviruses. Finally, we discovered that these two compounds were highly effective against authentic SARS-CoV-2 viruses, including the WH01, Delta, and Omicron strains. Our study identified potential broad-spectrum SARS-CoV-2 inhibitors and provided insights into the development of novel therapeutics.

简介：AbstractPlacenta accreta spectrum is a complication of pregnancy, which poses a great risk on maternal health. Historically, hysterectomy was the modality of treatment of such condition, but an approach towards a more conservative management has been in the light recently. This includes several methods with varying rates of success and complications. Expectant management is effective in up to 78%-80% of the cases. The extirpative method is associated with a high risk of postpartum hemorrhage. The success of the one-step conservative procedure depends on the degree of placental invasion, and the triple-P procedure appears to be successful but requires and interdisciplinary approach. Adjuvant treatment options can be tailored according to individual cases, and these include methotrexate injection, uterine devascularization and hysteroscopic resection of retained placental tissues. Follow up after conservative management is crucial to detect complications early, and it can be done by ultrasound, Doppler examination, and trending β human chorionic gonadotropin levels. Conservative management of placenta accreta spectrum can preserve future fertility but should only be done in hospitals with enough experience as it carries a high risk of maternal complications. In the future, more research should be directed to achieve clear guidelines regarding this topic.

简介：AbstractFibroblast growth factor 21 (FGF21) is a fasting or stress inducible metabolic hormone produced mainly in the liver. It plays important roles in regulating both glucose and lipid homeostasis via interacting with a heterodimeric receptor complex comprising FGF receptor 1 (FGFR1) and β-klotho (KLB). For the past decade, great effort has been made on developing FGF21 derivatives or specific FGF21 receptor agonists into therapeutic agents for various metabolic disorders including type 2 diabetes (T2D), obesity, and more importantly, nonalcoholic fatty liver disease (NAFLD). Here we have reviewed FGF21 gene and protein structures, its expression pattern, cellular signaling cascades that mediate FGF21 production and function. We have then summarized the six clinical trials utilizing four FGF21 analogues. Finally, two recent literatures on the development of GLP-1 and FGF21 dual agonists were presented briefly.

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简介：Inthispaper,anoptimalcontrolproblemgovernedbysemilinearparabolicequationwhichinvolvesthecontrolvariableactingonforcingtermandcoefficientsappearinginthehigherorderderivativetermsisformulatedandanalyzed.Thestrongvariationmethod,dueoriginallytoMayneetaltosolvetheoptimalcontrolproblemofalumpedparametersystem,isextendedtosolveanoptimalcontrolproblemgovernedbysemilinearparabolicequation,anecessaryconditionisobtained,thestrongvariationalgorithmforthisoptimalcontrolproblemispresented,andthecorrespondingconvergenceresultofthealgorithmisverified.

简介：TheBacklundtransformation(BT)forafifthorderKdVequationispresentedinthebilinearform.Furthermore,anonlinearsuperpositionformularelatedtotheBTobtainedaboveisprovedrigorously.Bytheway,anonlinearsuperpositionformulaofamodifiedfifthorderKdVequationisalsogiven.