简介：Hepatocellularcarcinoma(HCC),thepredominantformofadultlivermalignancies,isaglobalhealthconcern.Itsdismalprognosishaspromptedrecentsignificantadvancesintheunderstandingofitsetiologyandpathogenesis.Thederegulationofepigeneticmechanisms,whichmaintainheritablegeneexpressionchangesandchromatinorganization,isimplicatedinthedevelopmentofmultiplecancers,includingHCC.ThisreviewsummarizesthecurrentknowledgeofepigeneticmechanismsinthepathogenesisofHCC,withanemphasisonHCCmediatedbychronichepatitisBvirusinfection.Thisreviewalsodiscussestheencouragingoutcomesandlessonslearntfromepigenetictherapiesforhematologicalandothersolidcancers,andhighlightsthefuturepotentialofsimilartherapiesinthetreatmentofHCC.

简介：WithDNA-mRNAhybridizationinsitutechnique,theexpressionoffiveoncogenes,c-N-ras,c-Ki-ras.c-Ha-ras,c-mycandc-fos,wasobservedintwocasesofhumanhepatocellularcarcinoma.Theexpressionofc-N-ras&c-foswasgreatlyenhancedintumortissuesofthetwocases,andabout25%-50%ofthetumorcellsshowedpositiveexpression.Theotherthreeoncogenesnamelyc-Ki-ras,c-Ha-ras&c-myc,werenotdetectedinthesetwocarcinomasorinthenon-cancerouslivertissuesadjacenttothecarcinomas.Itissurmisedthatc-N-rasandc-fosmayplaycoordinativeroleinmaintainingthemalignantphenotypeofhumanprimaryhepatocellularcarcinoma.

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简介：流行病学的研究为长期的肝炎B的一个原因的角色提供了压到优势的证据在hepatocellular癌(HCC)的发展的病毒(HBV)感染。然而，HBV感染的致病和联系HBV的HCC的carcinogenesis仍然是逃犯的。这评论将在涉及HBV相关的肝carcinogenesis的机制上总结当前的知识。在肿瘤形成的HBV的角色出现到复杂，并且可以包含直接、间接的机制。进主人染色体的HBVDNA的集成发生在同种细胞的肿瘤的早步扩大，和它被显示了提高主人chromosomal不稳定性，导致大转换复制，删除和chromosomaltranslocations。chromosomal改变的率在HBV相关的肿瘤显著地被增加，这被显示出。病毒的规章的HBVx蛋白质的延长表示可以贡献调整表明小径的细胞的抄写，蛋白质降级，增长，和apoptotic，并且它在hepatocellular癌的发展起一个关键作用。

简介：ＡＤＥＮＯＳＱＵＡＭＯＵＳＣＡＲＣＩＮＯＭＡＯＦＴＨＥＮＡＳＯＰＨＡＲＹＮＸＣＯＮＴＡＩＮＩＮＧＥＢＶＩＲＵＳ，ＡＰＲＯＰＯＳＯＦＡＣＡＳＥＺｈａｎｇＦｅｎｇ张锋；ＺｈａｎｇＣｈａｎｇｑｉｎｇ张昌卿；ＺｈａｎｇＪｉｎｘｉａ张锦霞；ＺｏｎｇＹｏｎｇｓｈ...

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简介：Objective:Puremucinousbreastcarcinoma(PMBC)isanuncommonhistologicaltypeofbreastcancercharacterizedbyalargeamountofmucinproduction.MicroRNA(miRNA)isalargeclassofsmallnoncodingRNAofabout22ntinvolvedintheregulationofvariousbiologicalprocesses.ThisstudyaimstoidentifythemiRNAexpressionprofileinPMBC.Methods:MiRNAexpressionprofilesin11PMBCswereanalyzedbymiRNA-microarrayandreal-timepolymerasechainreaction(PCR).Thirty-onePMBCsand27invasiveductalcarcinomaofnospecialtypes(IDC-NSTs)wereassessedbyimmunohistochemistryusingantibodiesagainstER,PR-progesteronereceptor,HER2,Ki-67,Bcl-2,p53,PCNA,andCK5and6.Results:WeanalyzedthemiRNAexpressionin11PMBCsandcorrespondingnormaltissuesusingmiRNA-microarrayandreal-timePCR,andfoundthatmiR-143andmiR-224-5pweresignificantlydownregulatedinmucinouscarcinomatissue.ComparedwithIDC-NSTs,PMBCshowedasignificantlyhigherERpositiverate,lowerHER-2positiverate,andlowercellproliferationrates.Conclusions:Toourknowledge,thisisthefirststudytodemonstratethemiRNAexpressionprofileofPMBC,andourfindingsmayleadtofurtherunderstandingofthistypeofbreastcancer.

简介：目的将在hepatocellular癌(HCC)调查cortactin表示并且在HCC病人的预后探索它的意义。方法Immunohistochemistry被执行让119HCC纸巾(HCC)和paratumorous肝纸巾(PTLT)的石蜡样品计算cortactin表达式。在HCC和PTLT的cortactin表示差别被McNemars测试分析。在HCC和clinicopathologic因素的cortactin表情的关系与Mann-WhitneyU测试被分析。Kaplan-Meier方法和木头等级测试被采用比较在Cortactin否定表示组，弱表示组和强壮的表示组之间的全面幸存。cortactin的表示进一步与西方的弄污在19个新鲜HCC和PTLT标本被决定。结果Cortactin表示率在HCC是显著地更高的(53/119，44.5%)比那在PTLT(2/119，1.7%)(P<0.001)。在HCC的upregulatedcortactin表示显著地被相关到形成(P=0.012)，脉管的侵略(P=0.037)和高Edmondson啤酒杯杯分级的囊的缺席(P=0.020)，并且预言了更短的全面幸存。西方的弄污证明那cortactin表情与相应PTLT相比从19HCC(47.4%)是在9的upregulated。结论Cortactin表示是在HCC的upregulated并且与病人的更短的全面幸存有关，建议cortactin可能起在HCC的转移的作用并且预言HCC病人的差的预后。

简介：Enterovesicalfistulasarenotuncommoninpatientswithinflammatoryormalignantcolonicdisease,however,fistulassecondarytoprimarybladdercarcinomasareextremelyrare.Wehereinreportedapatientpresentingwithintractableurinarytractinfectionduetoenterovesicalfistulaformationcausedbyasquamouscellcarcinomaoftheurinarybladder.Thispatientunderwentenblocresectionofthebladderdomeandinvolvedileum,andrecovereduneventfullywithouturinarycomplaint.Tothebestofourknowledge,thisisthefirstcasereportedintheliterature.

简介：ＤＩＥＬＥＣＴＲＩＣＰＲＯＰＥＲＴＩＥＳＯＦＨＵＭＡＮＢＲＥＡＳＴＣＡＲＣＩＮＯＭＡＡＮＤＳＵＲＲＯＵＮＤＩＮＧＴＩＳＳＵＥＳＤＩＥＬＥＣＴＲＩＣＰＲＯＰＥＲＴＩＥＳＯＦＨＵＭＡＮＢＲＥＡＳＴＣＡＲＣＩＮＯＭＡＡＮＤＳＵＲＲＯＵＮＤＩＮＧＴＩＳＳＵＥ...

简介：这研究寻求了在病理学的ENE阴茎癌估计extranodal扩展(ENE)和几个另外的风险因素的度的预示的意义。我们分析了有希望地与证明ENE在31个化疗天真的病人的一个连续系列上收集了数据经历了治疗学的地区性的lymphadenectomy。手术后的外部放射疗法然后被执行。我们学习了一个新奇分级系统和相关病人与他们的结果措施分级的利用的ENE的程度。ENE作为1被分级-如果淋巴节点(行)的囊被破裂不到三分之一个它的圆周或2-如果囊被破坏，超过三分之一个它的圆周或全部行被破坏。我们用Kaplan-Meier方法估计了全面幸存(OS)。Multivariate分析根据比例的危险用在univariate分析作为统计上重要被识别的因素建模的考克斯的意见被执行。ENE的发生率在有阴茎的病理学的节点积极的癌的病人是51.8%。中部的OS和5年的幸存是18个月(95%信心间隔(CI)，14.4-21.6)并且23%分别地。univariate分析上的预示的变量是ENE等级2，≥；有ENE的3行，最大的行≥；35公里，≥；5积极的行和骨盆的行参与。在multivariate分析上，仅仅ENE等级2仍然保持与减少的OS联系了(危险比率(HR)：6.50)。在结论，有ENE的病人有等级2是的差的结果，和ENE在有病理学的ENE的病人的差的OS的一个独立预兆的因素阴茎癌。

简介：AbstractIntroduction:Basal cell carcinoma (BCC) is the most common human malignancy commonly in white people, but in less than 1% of cases it may appear on unexposed areas, like the perineal and anal regions. Vulvar BCC is often diagnosed late because it grows slowly and tends to be asymptomatic, with no specific physical findings. Here, we present a rare Latin patient with a 10-year history of vulvar BCC with dermatoscopic and histopathologic findings.Case report:A 65-year-old Latin woman presented with a nodule on her left labium majus, which she first noted 10 years ago, and that had grown slowly but constantly. She also reported a 20-year history of pruritus and occasional pain. Physical examination showed a 3.5 cm × 3.0 cm erythematous lesion with a central rough without inguinal lymphadenopathy. Contact dermatoscopy (Dermalite DL3 Gen.) showed one blurred cluster of arborising vessels in a pinkish background with white homogeneous areas and lines radial converging. An incisional biopsy was realized, and histopathology diagnosed BCC.Discussion:Vulvar BCC is a rare malignancy that affects mainly Caucasian women over 70 years of age. The most common etiology for BCC is ultraviolet radiation, but as the vulva is unexposed its cause is unclear. Mutations in tumor suppressor and regulatory genes such as p53 are present in 50% of cases. Gorlin syndrome, chronic radiation, chronic arsenic exposure, xeroderma pigmentosum, and immunosuppression have been considered as risk factors.Conclusion:Vulvar BCC characteristics are the same as other cutaneous forms, featuring blue ovoid nests and arborizing telangiectasia, confused with inflammatory diseases, such as eczema, psoriasis, and chronic infection (especially if it is accompanied by pruritus), this makes diagnosis complex, with a delay of 5 to 6 years on average, with an average size of 2.1 cm. Diagnosis is enhanced with dermatoscopy, as the preferred treatment for most BCC cases is wide surgical excision.

简介：AbstractIntroduction:Basal cell carcinoma (BCC) is the most common skin cancer which mainly affects the population over 50 years of age. In addition to surgical treatment, nonsurgical treatment is also an attractive option for some patients.We herein report a case of an 82-year-old man with BCC successfully treated with acitretin.Case presentation:An 82-year-old man presented with BCC on his left nose wing more than 2 years ago. Due to his unwillingness to accept treatment that may lead to pain, discomfort, or trauma, the patient was prescribed oral acitretin 25 mg twice daily [0.8 mg/(kg·d)] and was instructed to apply 2% fusidic acid cream topically once daily for trauma protection. The lesion progressively shrank in size after 4 weeks of treatment, and was almost completely resolved after 28 weeks of follow-up. The patient reported mild adverse effects, such as mild skin fragility and cheilitis, and apparent scaling skin, which caused minor discomfort but did not affect the continuation of treatment.Discussion:The pathogenesis of BCC is still unclear, but it has been demonstrated to be linked to overactive hedgehog signaling and its crosstalk with other pathways such as phosphoinositide 3-kinase and mammalian target of rapamycin. Acitretin could obviously inhibit cell growth and proliferation and down-regulate AMP-dependent protein kinases that plays critical role in the blocking of malignant progression of several tumors including BCC.Conclusion:We provide an effective alternative for the patients with BCC who are unwilling to receive surgical therapy.

简介：Theeffectofportalveintumorthrombus(PVTT)ontheprognosisofpatientswithhepatocellularcarcinomahasbecomeclearoverthepastseveraldecades.However,identifyingthemechanismsandperformingthediagnosisandtreatmentofPVTTremainchallenging.Therefore,thisstudyaimedtosummarizetheprogressintheseareas.AcomputerizedliteraturesearchinMedlineandEMBASEwasperformedwiththefollowingcombinationsofsearchterms:'hepatocellularcarcinoma'AND'portalveintumorthrombus.'AlthoughseveralsignaltransductionormolecularpathwaysrelatedtoPVTThavebeenidentified,theexactmechanismsofPVTTarestilllargelyunknown.Manybiomarkershavebeenreportedtodetectmicrovascularinvasion,butnonehaveprovedtobeclinicallyusefulbecauseoftheirlowaccuracyrates.SorafenibistheonlyrecommendedtherapeuticstrategyinWesterncountries.However,moretreatmentoptionsarerecommendedinEasterncountries,includingsurgery,radiotherapy(RT),transhepaticarterialchemoembolization(TACE),transarterialradioembolization(TARE),andsorafenib.Therefore,weestablishedastagingsystembasedontheextentofportalveininvasion.Ourstagingsystemeffectivelypredictsthelong-termsurvivalofPVTTpatients.Currently,severalclinicaltrialshadshownthatsurgeryiseffectiveandsafeinsomePVTTpatients.RT,TARE,andTACEcanalsobeperformedsafelyinpatientswithgoodliverfunction.However,onlyafewcomparativeclinicaltrialshadcomparedtheeffectivenessofthesetreatments.Therefore,morerandomizedcontrolledtrialsexaminingtheextentofPVTTshouldbeconductedinthefuture.

简介：AIM:Toevaluatetheshort-andlong-termoutcomesofliverresectionforcaudatelobehepatocellularcarcinoma(HCC).METHODS:Weretrospectivelyanalyzed114consecutivepatientswithHCC,originatingfromthecaudatelobe,whounderwentresectionbetweenJanuary2001andJanuary2007.Univariateandmultivariateanalyseswereperformedonseveralclinicopathologicvariablestodeterminethefactorsaffectinglong-termoutcomeandintrahepaticrecurrence.RESULTS:Overallmortalityandmorbiditywere0%and18%,respectively.Afteramedianfollow-upof31mo(interquartilerange,11-66mo),tumorrecurrencehadoccurredin76patients(66.7%).The1-,3-,and5-yeardisease-freesurvivalrateswere65.7%,38.1%,and18.4%,respectively.The1-,3-,and5-yearoverallsurvivalrateswere76.1%,54.7%,and31.8%,respectively.Univariateanalysisshowedthatsubsegmentallocationofthetumor(45.7%vs16.2%,P=0.01),livercirrhosis(12.3%vs47.9%,P=0.03),surgicalmargin(18.5%vs54.6%,P=0.04),vascularinvasion(37.9%vs23.2%,P=0.04)andextendedcaudateresection(42.1%vs15.4%,P=0.04)wererelatedtopoorerlong-termsurvival.Multivariateanalysisshowedthatonlysubsegmentallocationofthetumor,livercirrhosisandsurgicalmarginweresignificantindependentprognosticfactors.CONCLUSION:HepatectomywasaneffectivetreatmentforHCCinthecaudatelobe.Thesubsegmentallocationofthetumor,livercirrhosisandsurgicalmarginaffectedlong-termsurvival.

简介：Esophagealcancerisoneofthemostfataldiseasesworldwidemainlybecauseofitsrapidprogressionandpoorprognosis.AlthoughtheincidenceofesophagealadenocarcinomahasmarkedlyriseninNorthAmericaandEuropeinthepastseveraldecades,esophagealsquamouscellcarcinomaisstillthepredominantsubtypeofesophagealcancer,especiallyinChina.Itaccountsformorethan90%ofallesophagealsquamouscellcarcinomacasesinChina.Geographicaldifferentiationisoneofthemostdistinctivecharacteristicsofesophagealcancer.Theprogression,riskfactors,andprognosisofthesetwosubtypesofesophagealcancerdiffer.Thisstudyreviewstheepidemiology,etiology,andpreventionofesophagealsquamouscellcarcinomainChina,therebyprovidingsystematicreferencesforpolicy-makerswhowilldecideonissuesofesophagealcancerpreventionandcontrol.

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简介：AbstractObjective:To evaluate the survival outcomes for a cohort of nasopharyngeal cancer with intracranial extension (ICE) treated with induction chemotherapy (ICT) followed by chemo-intensity-modulated radiotherapy (CTRT) at a tertiary cancer center.Methods:We retrospectively analyzed 45 patients with histologically proven, non-metastatic NPC with ICE treated at our institute between October 2008 and October 2016. Patients were classified as minor ICE or major ICE, based on the extent of ICE. All the patients received 2-3 cycles of a taxane-based ICT regimen followed by CTRT. Radiotherapy was delivered with "riskadapted" intensity-modulated radiotherapy (IMRT) technique in all patients.Results:After a median follow up of 45 months (range: 8-113 months), the estimated 5-year DFS, LRFS, DMFS, and OS of the entire cohort was 58%, 82%, 67% and 74% respectively. On multivariate analysis, histological subtype was an independent predictor of LRFS, and age was an independent predictor of DFS. The extent of ICE showed only a trend towards worse DFS (P= 0.06). None of the factors significantly predicted for DMFS or OS. Gender, N-stage, and response to ICT did not significantly affect any of the outcomes. Grade 2 or worse subcutaneous fibrosis was seen in 22% of patients and grade 2 or worse xerostomia was seen in 24% of patients at last follow up. Thirty-three percent of the patients developed clinical hypothyroidism at last follow up. None of the patients experienced any neurological or vascular complications.Conclusions:Taxane-based induction chemotherapy followed by chemo-intensity modulated radiotherapy resulted in excellent locoregional control and survival with acceptable toxicities in patients of nasopharyngeal cancer with intracranial extension. Distant metastasis continues to be the predominant problem in these patients.

简介：ＡＣＬＩＮＩＣＡＬＲＥＰＯＲＴＯＦＲＥＦＲＡＣＴＯＴＹＣＡＲＣＩＮＯＭＡＯＦＯＶＡＲＹＡＮＤＦＡＬＬＯＰＩＡＮＴＵＢＥＴＲＥＡＴＥＤＷＩＴＨＴＡＸＯＬＣａｉＳｈｕｍｏ蔡树模；ＴａｎｇＪｉｅ汤洁；ＦａｎＪｉａｎｘｕａｎ范建玄；ＷｅｎｇＺｈｏｎｇｙｉｎｇ...

简介：客观：在人的hepatocellular癌(HCC)在HLA医生表示上调查干扰素(IFN)的管理效果。方法：房间衬里的在4种HCC的HLA医生的表示，HHCC，SMMC-7721，BEL-7402，HCC-9204和一个正常的肝房间衬里QZG在被IFN-或IFN-的不同剂量刺激前后与immunohistochemicalABC和ELISA方法被检测。结果：仅仅SMMC-7721房间的小部分表示了另外的房间线的HLA医生，和所有是在有IFN-或IFN-的刺激前否定的HLA医生。HLA医生表示在刺激以后5根房间线在所有被提高，并且它与IFN的剂量被相关。QZG房间不比HCC房间明显。IFN-的效果比IFN-的更明显。结论：IFN能在HCC房间提高HLA医生表示。