简介:Underdifferentreactionconditions,theexpectedandunexpectedreactionproducts(ofwhichX-raycrystallographicstructurewaspresented)ofetherificationof2-per(poly)fluoroethyl4-substitutedphenolwithβ-haloethanolcanbeobtainedrespectively.
简介:Thecellulosetris(4-methylbenzoate)hasbeensynthesisedbythecatalyticmethodandwassupportedatGasChromQ.Theabsorptioncapabilityofcellulosetris(4-methylbenzoate)usedasagaschromatographicstationaryphasewascharacterizedbychromatographicmethodandtheClausius-Clapeyronequation.However,n-alcohols(C1-C8)weresuccessfullyseparatedonthecolumnpackedwithGasChromQcoatedwithcellullosetris(4-methylbenzoate).
简介:IntroductionSelenoetherplatinumcomplexesasanewkindofhydrosilylationcatalysthavebeendrawnmuchatentionrecently.Aseriesofselenoe...
简介:Ahigherβ-glucosidase-producingstrainwasisolatedandidentifiedasTolypocladiumcylindrosporumsyzx4basedonitsmorphologyandinternaltranscribedspacer(ITS)rDNAgenesequence.Thepresentstudyistoferment,purifyandcharacterizeaβ-glucosidasefromT.cylindrosporumgams.Theenzymewaspurifiedtohomogeneitybysulfateprecipitataion,diethylaminoethylcelluloseanionexchangechromatographyandSephadexG-100gelfiltrationwitha9.47-foldincreaseinspecificactivityandarecoveryof12.27%.Themolecularweight(Mw)oftheβ-glucosidasewasestimatedtobe58600bySDS-PAGE,whichismuchlowerthanthatoftheenzymefromotherfungi.Theβ-glucosidaseshowshighactivityoverawiderangeoftemperaturefrom35℃to70℃andtheoptimumpHisapproximately2.4.ThenthekineticparametersKm(0.85mmol/L)andvmax[85.23mmol/(L·s)]oftheβ-glucosidasewerestudied,respectivelywithhighaffinityp-nitrophenyl-β-D-glucopyranoside(p-NPG)asthesubstrate,inhibitionconstantKi(39.5mmol/L)withthetoleranceofglucose.Althoughβ-glucosidaseshavebeenpurifiedandcharacterizedfromseveralothersources,T.cylindrosporumβ-glucosidasewiththeuniqueoptimalpHandhighertoleranceofglucosedistinguishedfromothersmakestheβ-glucosidaseapotentialapplicationinsimultaneoussaccharificationandfermentation(SSF).
简介:新精力充沛的材料,4,5-diacetoxyl-2-(dinitromethylene)-imidazolidine(DADNI),被4,5-dihydroxyl-2-(dinitromethylene)的反应综合-imidazolidine(DDNI)和醋性的酐,并且由单个水晶X光检查衍射描绘了。为DADNI的水晶数据是单斜晶的,空间组C2/c,a=15.9167(3)?,b=8.6816(4)?,c=8.5209(3)?,=103.294(9)獩潩?硯杹湥戭浯?潣扭獵楴湯挠污牯浩瑥牥愠?啣????7敢?敤楬敶敲?景吗?
简介:DrugsSPD-304(6,7-dimethyl-3-{[methyl-(2-{methyl-[1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl]-amino}-ethyl)-amino]-methyl}-chromen-4-one)andzafirlukastcontainacommonstructuralelementof3-substitutedindolemoietywhichcloselyrelatestoadehydrogenatedreactioncatalyzedbycytochromeP450s(CYPs).ItwasreportedthatthedehydrogenationcanproduceareactiveelectrophilicintermediatewhichcausetoxicitiesandinactivateCYPs.DrugL-745,870(3-{[4-(4-chlorophenyl)piperazin-1-yl]-methyl}-1H-pyrrolo2,3-β-pyridine)mighthavesimilareffectsinceitcontainsthesamestructuralelement.Weusedmoleculardockingapproachcombinedwithmoleculardynamics(MD)simulationtomodelthree-dimensional(3D)complexstructuresofSPD-304,zafirlukastandL-745,870intoCYP3A4,respectively.Theresultsshowthatthesethreedrugscanstablybindintotheactivesiteandthe3-methylenecarbonsofthedrugskeepareasonablereactivedistancefromthehemeiron.ThecomplexstructureofSPD-304-CYP3A4isinagreementwithexperimentaldata.Forzafirlukast,thecalculationresultsindicatethat3-methylenecarbonmightbethedehydrogenationreactionsite.DockingmodelofL-745,870-CYP3A4showsapotentialpossibilityofL-745,870dehydrogenatedbyCYP3A4at3-methylenecarbonwhichisinagreementwithexperimentinvivo.Inaddition,residuesinthephenylalanineclusteraswellasS119andR212playacriticalroleintheligandsbindingbasedonourcalculations.ThedockingmodelscouldprovidesomecluestounderstandthemetabolicmechanismofthedrugsbyCYP3A4.
简介:Inthispaperwereportachemicaloscillationcatalyzedby[Ni(Me2[14]1,3-dieneN4)]2+(Me2[14]l,3-dieneN4denotes2,3-dimethyl-l,4,8,ll-tetraazacyclotetradeca-1,3-diene)inBrO3--pyruvicacid-H2SO4system.Thedomainoftheexistenceoftheoscillationwasobtained.Theeffectsofinitialconcentrationofthecomponentsontheoscillationwerestudied.Thefeaturesoftheoscillationsweredescribedindetail.WealsoexaminedtheeffectsofAg+,Hg2+,CCl4,freeradicalinhibitors,etc.ontheosillations.
简介:Theabinitiomolecularorbitalmethodisemployedtostudytheenantioselectivereductionofacetophenonewithboranecatalyzedbythiszolidino[3,4-c]oxazaborolidine.Computationresultshowsthatthecontrollingstepforthereductionisthedecompositionofthecatalyst-alkoxyboraneadductandthereductionleadstoS-alcohols.ThetransitionatateofthehydridetransferfromtheboranemoietytothecarbonylcarbonofacetophenoneisatwistedchairstructurewithaB(2)-N(3)-BBH3-HBH3-CCo-OCO6-memberedring.
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简介:SYNTHESISOF3-ARYL-1(2H,4H)ACRIDONESANDTHEIRDERIVATIVES¥RongYIN;GuangFanHAN;YuTianLI(DepartmentofMedicalLaboratory,JilinMediea...
简介:Thenanomaterialsoftenexhibitveryinterestingelectrical,optical,magnetic,andchemicalproperties,whichcannotbeachievedbytheirbulkcounterparts[1-7].Thedevelopmentofuniformnanometersizedparticleshasbeenintensivelypursuedbecauseoftheirtechnologicalandfundamentalscientificimportance[8-15].Itissignificantthatnanostructuredmaterialscanbecontrollablyassembledintotherequiredgeometryontosubstrates,becomingthebasisofthenextgenerationofcomponentsanddevices[16-31].Thedevelopmentofnewmethodsandstrategiesfororganizingthenanoparticlebasicbuildingblocksintothedesiredstructuresisrequired.Superlatticesmadefromthesebuildingblocksgiveustheopportunitytostudynotonlythepropertiesoftheindividualbuildingblocks,butalsocollectiveeffects.Thesuperparamagneticironoxidenanocrystals(NCs)havebeenusedinthefieldsofbio-medicine,ferrofluids,refrigerationsystem,catalysis,particularlyinmagneticresonanceimaging,tissueengineering,anddrugdeliveryapplications[32-42].
简介:Graphitic碳氮化物(g-C3有向在可见轻照耀下面的4-nitrophenol的降级的高photocatalytic活动的N4)被蚀刻的HCl准备由氨中立化列在后面。准备样品的结构,形态学,表面区域,和photocatalytic性质被学习。在处理以后,g-C3N4从几测微计减少了到几百纳米,和g-C3N4从11.5 增加了;m2/g到115 ;m2/g。同时,g-C3N4显著地在可见的光下面向4-nitrophenol的降级在处理以后被改进照耀。小粒子g-C3N4是5.7次体积g-C3为水处理和环境补习为未来应用使它成为有希望的可见轻光催化剂的N4,。
简介:Thedifferentregioselectiveandstereoselectiveproductswereobtainedbythereductionofstigmast-4,22-dien-3,6-dionewithNaBH4-CH3OHwhendifferentkindsofmetalionswasaddedtothereaction.
简介:SYNTHESIS AND SPECTRA STUDIES OF TRANSITION METAL COMPLEXES DERIVED FROM 2, 4-DINITROPHENYL HYDRAZINESYNTHESISANDSPECTRASTUDI...