Schisandra N-butanol extract improves synaptic morphology and plasticity in ovarectomized mice-中国期刊网

摘要 PreliminaryworkbyourresearchteamrevealedthatSchisandra,arenownedtraditionalChinesemedicine,causeslearningandmemoryimprovementsinovariectomizedmice.ThisactivitywasattributedtoactiveingredientsextractedwithN-butylalcohol,namedSchisandraN-butanolextract.Inthisstudy,ovariectomizedmicewerepretreatedwithSchisandraN-butanolextractgivenbyintragastricadministration.Thistreatmentledtotheenhancementoflearning,andanincreaseinhippocampalCA1synaptic,surfaceandpostsynapticdensity.Adecreaseintheaveragesizeofthesynapticactivezonewasalsoobserved.TheseexperimentalfindingsshowingthatSchisandraN-butanolextractimprovedsynapticmorphologyindicateanunderlyingmechanismbywhichtheabilityoflearningisenhancedinovariectomizedmice.

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Schisandra N-butanol extract improves synaptic morphology and plasticity in ovarectomized mice

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Schisandra N-butanol extract improves synaptic morphology and plasticity in ovarectomized mice

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