Neuroprotective effect of ischemic preconditioning in focal cerebral infarction：relationship with upregulation of vascular endothelial growth factor-中国期刊网

摘要 Neuroprotectionbyischemicpreconditioninghasbeenconfirmedbymanystudies,buttheprecisemechanismremainsunclear.Inthepresentstudy,weperformedcerebralischemicpreconditioninginratsbysimulatingatransientischemicattacktwice(eacha20-minuteocclusionofthemiddlecerebralartery)beforeinducingfocalcerebralinfarction(2hourocclusion-reperfusioninthesameartery).Wealsoexploredthemechanismunderlyingtheneuroprotectiveeffectofischemicpreconditioning.Sevendaysafterocclusion-reperfusion,tetrazoliumchloridestainingandimmunohistochemistryrevealedthattheinfarctvolumewassignificantlysmallerinthegroupthatunderwentpreconditioningthaninthemodelgroup.Furthermore,vascularendothelialgrowthfactorimmunoreactivitywasconsiderablygreaterinthehippocampalCA3regionofpreconditionedratsthanmodelrats.Ourresultssuggestthattheprotectiveeffectsofischemicpreconditioningonfocalcerebralinfarctionareassociatedwithupregulationofvascularendothelialgrowthfactor.

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Neuroprotective effect of ischemic preconditioning in focal cerebral infarction：relationship with upregulation of vascular endothelial growth factor

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Neuroprotective effect of ischemic preconditioning in focal cerebral infarction：relationship with upregulation of vascular endothelial growth factor

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