Resuscitation therapy for traumatic brain injury-induced coma in rats：mechanisms of median nerve electrical stimulation-中国期刊网

摘要 Inthisstudy,ratswereputintotraumaticbraininjury-inducedcomaandtreatedwithmediannerveelectricalstimulation.Weexploredthewake-promotingeffect,andpossiblemechanisms,ofmediannerveelectricalstimulation.Electricalstimulationupregulatedtheexpressionlevelsoforexin-AanditsreceptorOX1Rintheratprefrontalcortex.Orexin-Aexpressiongraduallyincreasedwithincreasingstimulation,whileOX1Rexpressionreachedapeakat12hoursandthendecreased.Inaddition,aftertheOX1Rantagonist,SB334867,wasinjectedintothebrainofratsaftertraumaticbraininjury,fewerratswererestoredtoconsciousness,andorexin-AandOXIRexpressionintheprefrontalcortexwasdownregulated.Ourfindingsindicatethatmediannerveelectricalstimulationinducedanup-regulationoforexin-AandOX1Rexpressionintheprefrontalcortexoftraumaticbraininjury-inducedcomarats,whichmaybeapotentialmechanisminvolvedinthewake-promotingeffectsofmediannerveelectricalstimulation.

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Resuscitation therapy for traumatic brain injury-induced coma in rats：mechanisms of median nerve electrical stimulation

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Resuscitation therapy for traumatic brain injury-induced coma in rats：mechanisms of median nerve electrical stimulation

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