摘要
FollowingreparativesurgeryfortetralogyofFallotorcriticalpulmonarystenosis(PS),patientsfrequentlypresentwithsevererightventricular(RV)volumeoverloadduetopulmonaryregurgitation,resultingindecreasedRVfunction.Surgicalpulmonaryvalvereplacement(PVR)isknowntoimproveRVfunction,butchangesinleftventricular(LV)functionafterPVRhaverarelybeendescribed.WesoughttodeterminethemidtermresultsregardingLVsystolicfunctionafterPVRusingcardiacMRIin40consecutivepatientswithrepairedTOF(31patients)orPS(9patients)withanageof29±9yearswhounderwentPVRfrom2006to2011atasinglecenter.CardiacMRIRVandLVvolumesbeforeandafterPVRwereanalyzed.Demographics,clinicalvariables,cardiopulmonarybypassduration,andmedicationswerereviewed.LVejectionfraction(LVEF)increasedfrom(54±8)to(57±6)%(P=0.02).BeforePVR,26patientshaddepressedLVEFof(49±5)%(range36–54%).Inthisgroup,LVEFincreasedby(7±7)%(P<0.0001)afterPVR.LowLVEFbeforePVRwascorrelatedwithincreasedLVEFafterPVR(regressioncoefficient-0.7,R2=0.59,P<0.0001).Demographics,medications,priorpregnancies,andcardiopulmonarybypassdurationhadnoeffectonLVEFafterPVR.TheincreaseinLVEFwasmostsignificantinpatientswithlowpre-PVRLVEF.
出版日期
2018年11月17日（中国期刊网平台首次上网日期，不代表论文的发表时间）
