SELECTIVE KILLING OF GASTRIC CANCER CELLS BY MONOCLONAL ANTIBODY CONJUGATED WITH A CHAIN OF RICIN

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摘要 AspecificcytotoxicagentagainstgastriccancerwasconstructedbycovalentlycouplingthericinAchaintomonoclonalartibody,MGb2.MGb2wasmodifiedbySPDPtointroducethe3-(2-pyridylthio)propionylradicalandthentreatedwithareducedAchaintogiveadisulfidelinkedconjugatethatretainedtheoriginalbindingspecificityoftheantibodymoiety.TheconjugateobtainedretainedtheactivityoftheantibodyandthebiologicalactivityoftheAchainwell.
机构地区 不详
出版日期 1989年03月13日(中国期刊网平台首次上网日期,不代表论文的发表时间)
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