Preparation of Optically Active Compounds by Combination of Chemical and Enzymatic Methods

(整期优先)网络出版时间:2001-11-04
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Manynaturalproductscontainγ-lactonemoieties.Forexample,β-methyl-γ-butyl-γ-lactones(quercuslactones)aregradientsofagedwhiskey,andβ-methyl-γ-(3-methyl-2-butenyl)-γ-lactone(eldanolide)isapheromoneoftheAfricansugarcaneborer.Wesynthesizedsuchγ-lactonesbyhydrolysesofthehomoallylicalcoholsobtainedbyadditionofaldehydestotheallylicanionsgeneratedfromketenedithioacetalsor2-propenyl-1,3-dithiane.