简介:AIM:Toevaluatethelong-termresultsandcomplicationsofahmedglaucomavalve(AGV)implantationinrefractoryglaucoma.·METHODS:Aretrospectivereviewof13patients(13eyes)withrefractoryglaucomawhounderwentAGVimplantationandhadaminimumfollow-upof18monthswasperformed.Allpatientsunderwentacompleteophthalmologicexaminationandintraocularpressure(IOP)measurementbeforesurgeryandat1month,3months,6months,1yearaftersurgeryandyearlyafterwards.Complicationsandthenumberofantiglaucomamedicationsneededwererecorded.·RESULTS:Meanagewas27.3±16.0years.Alleyes(100%)hadatleastonepriorincisionalsurgery.Meanfollow-upwas61.3±30.8months.IOPwasreducedfromameanof35.0±7.0mmHgto18.2±7.9mmHgat12monthsandto17.0±4.1mmHgat96months(P<0.05)withalowernumberofmedicationsfrombaseline,76.9%patientsrequiredadditionalprocedurestoachievethesuccesscriteriasetbypreviouslypublishedseries.Themostcommoncomplicationswereencapculatedcystformationineighteyes(61.5%)andtubeexposureinfoureyes(30.8%).·CONCLUSION:EncapsulatedcystformationwasthemostcommoncomplicationwhichhinderedsuccesfulIOPcontrolafterAGVimplantinsertionforrefractoryglaucoma.Despitecystexcisionwithanti-fibroticagents,successfulIOPreductionwasnotachievedin76.9%ofthepatientswithoutantiglaucomamedication.
简介:从多刺绿绒蒿MeconopsishorridulaHook.f.etThoms的全草中分离鉴定了13个化合物,分别为:木犀草素-7-O-β-D-葡萄糖苷(1)、山奈酚-3-O-β-D-葡萄糖(1→2)-β-D-葡萄糖苷(2)、槲皮素-3-O-β-D-半乳糖(1→6)-β-D-葡萄糖苷(3)、小麦黄素-7-O-β-D-葡萄糖苷(4)、山奈酚-3-O-β-D-葡萄糖(5)、桂皮酰胺(6)、对羟基桂皮酰胺对羟基苯乙胺(7)、小麦黄素(8)、木犀草素(9)、槲皮素(10)、芹菜素(11)、山奈酚-4′-甲醚(12)、山奈酚(13)。其中化合物1、5、6、7、12、13为首次从该属中分离得到,化合物2、3、4为首次从该植物中分离得到。
简介:摘要目的为了确保人工气道护理的质量,探讨改良气道湿化方法在人工气道中的应用价值。方法将86例人工气道患者,随机分为实验组(n=43)和对照组(n=43)。实验组微量泵连接三通管,前端连接延长管,侧端一次性的氧气管,氧流量为5L/ml。对照组微量泵直接连接延长管。2组微量泵速度均为5~10ml/h。比较2组患者气道湿化效果、依从性及气道湿化并发症。结果实验组湿化效果满意率、依从性、并发症发生率分别为88.4%、90.0%2.3.3%,对照组依次为67.4%、68.4%、58.1%,经比较,P<0.05,有统计学差异。结论改良气道湿化方法简单,有效,可以提高人工气道护理质量。
简介:·Glaucomaisoneoftheleadingcausesofvisualimpairmentandblindnessworldwide.Ofknownriskfactorsforglaucoma,anincreasedinintraocularpressureismosthighlycorrelatedwithglaucomatousdamage.Irrespectiveofthecause,apoptosisoftheretinalganglioncellsistheeventualoutcome.Itiswidelyacceptedthatglaucomaisaneurodegenerativediseasethatisstronglycorrelatedwithcentralnervoussystemdisorders,suchasAlzheimer’sdisease.Thesetwodisordersalsosharesomesimilaritiesinpathogenicmechanisms.Recentstudiessuggestthatthetransientreceptorpotentialcanonical6channelcouldworktogetherwithbrain-derivedneurotrophicfactortopromoteneuronsurvivalinbrainandretina.Inthisstudy,weproposethattransientreceptorpotentialcanonical6maycontributetothepathogenesisofhumanglaucomaandbecomeapotentialtherapeutictarget.