简介:摘要:本文依托HXD3C型电力机车C6级修为载体,依据轨道车辆制造行业的特点及各系统的管理方法,提出工位制节拍化生产基本实施方案,确保满足精益化生产的要求,最终达到提高机车组装效率,降低成本、提高利润,同时为减少机车在厂停时,提升企业竞争优势奠定基础。
简介:摘要目的评价髂静脉球囊扩张治疗对C3以上的浅静脉曲张患者临床症状的改善程度。方法选取新疆医科大学第一附属医院2016年6月至2018年6月收治的C3以上浅静脉曲张患者568例,按治疗方式分为介入球囊扩张组、弹力袜治疗组和剥脱手术组,使用静脉临床严重程度评分(VCSS)评价患者疗效。结果介入球囊扩张组47例,有效40例,无效7例;弹力袜治疗组82例,有效39例,无效43例;剥脱手术组439例,有效280例,无效159例。三组有效率比较差异有统计学意义(P<0.05),介入球囊扩张组症状改善程度高于其他两组(P<0.05)。结论球囊扩张髂静脉可以更好地改善部分C3以上浅静脉曲张患者的临床症状。
简介:摘要: C6MW汽轮机的油系统不仅担负着机组轴承的润滑冷却,而且还担负着机组的调速、保安任务,是 C6MW汽轮机安全运行的关键。 C6MW汽轮机的油系统中如果进水能造成轴承室内微负压、外缸变形、真空滤油机脱水效果差等危害。本文主要论述 C6MW汽轮机油中进水的原因及改进措施。
简介:[ 摘要 ] 采用膨胀法,结合金相法,测试了实验钢的临界转变点 Ac1 、 Ac3 及 Ms 点。测定了不同冷却温度下轧辊用钢 的膨胀曲线,得到了该材料的连续冷却转变曲线( CCT )。并根据温度对连续冷却转变过程中相转变的影响进行了探讨。
简介:摘要目的探讨肾小球补体C1q及C3c沉积与糖尿病肾病进展的相关性。方法纳入2011年1月至2019年7月在南京医科大学第一附属医院确诊的2型糖尿病肾病患者112例,其中男性83例(74.1%),年龄(51.22±11.12)岁,随访时间19.0(8.5,31.3)个月。根据肾小球C1q和C3c是否沉积分为四组:C1q无沉积C3c无沉积组(n=38)、C1q无沉积C3c沉积组(n=24)、C1q沉积C3c无沉积组(n=14)和C1q沉积C3c沉积组(n=36),检测24 h尿蛋白等临床指标并收集病理资料。采用Cox回归及Kaplan-Meier生存曲线评估肾C1q和C3c沉积对肾脏预后的影响。结果四组间24 h尿蛋白差异有统计学意义[分别为1.84(0.92,3.89),4.19(2.09,6.50)3.30(1.84,6.70),3.64(2.49,7.22)g/24 h,P<0.01],C1q沉积C3c沉积组24 h尿蛋白定量显著高于C1q无沉积C3c无沉积组(P<0.01)。Kaplan-Meier生存曲线结果提示,四组累积生存率差异有统计学意义(Log-rank χ²=8.785,P<0.05),C1q沉积C3c无沉积组累计生存率最低,预后最差。调整后的多因素Cox分析显示,肾小球C1q和C3c共沉积[风险比(HR)2.260,95%可信区间1.329~3.845,P<0.01]、肾小球C1q+C3c+IgM均沉积(HR=4.142,95%可信区间 1.071~16.021,P<0.05)是肾脏预后的独立危险因素。结论肾小球C1q及C3c沉积与糖尿病肾病患者蛋白尿、较差的肾功能和预后不良相关,且肾小球C1q和C3c共沉积是糖尿病肾病进展的独立危险因素。
简介:摘要目的建立C57BL/6小鼠放射性心肺功能不全动物模型。方法24只雄性C57BL/6小鼠随机分为对照组、照射组。照射组接受胸部局部单次20 Gy电子线照射,照后饲养6个月。超声心动检查心功能,血气分析检测血氧分压(PaO2),Tunel染色法检测细胞凋亡,Masson染色法检测心肺纤维化。结果照射组LVEF (68.60±10.92)%与对照组(81.75±8.79)%降低(P<0.01);照射组心脏凋亡指数(23.90±6.60)%比对照组(3.25±3.38)%增高(P<0.01);照射组心脏CVF (15.42±5.72)%比对照组(1.45±0.64)%增高(P<0.01)。照射组PaO2(86.10±7.60) mmHg比对照组PaO2(107.16±9.01) mmHg下降(P<0.01);照射组肺脏凋亡指数(27.90±8.94)%比对照组(2.50±3.55)%增高(P<0.01);照射组肺脏CVF (17.76±5.77)%比对照组(2.50±3.55)%增高(P<0.01)。结论辐射使心肺凋亡纤维化重塑,进而导致心肺功能的下降,成功构建C57BL/6小鼠放射性心肺功能不全动物模型。
简介:摘要目的对1例孕期超声提示肾脏增大、回声增强的胎儿进行全外显子组测序,以明确其病因。方法收集胎儿的影像学资料,穿刺收集羊水样本20 mL,抽取胎儿父母静脉血样各2 mL。提取羊水DNA进行文库构建和全外显子组测序,对与胎儿表型相关的变异位点进行家系Sanger测序验证。结果产前超声提示胎儿双肾增大、回声增强且肾内存在多个小囊肿。全外显子组测序发现胎儿ETFDH基因存在致病性复合杂合变异c.3G>C与c.1436dupA,家系Sanger测序提示上述变异分别遗传自其母亲和父亲。结论结合临床表现与全外显子组测序的结果,胎儿被诊断为戊二酸血症ⅡC型,其病因为ETFDH基因复合杂合变异。上述结果为胎儿的产前诊断及遗传咨询提供了依据。胎儿全外显子组测序将成为产前诊断的重要手段。
简介:AbstractBackground:Aberrant activation of the complement system plays an important role in the pathogenesis and development of immunoglobulin A nephropathy (IgAN). The relationship between serum complement and the clinical-histopathological features and outcomes of IgAN is controversial. This retrospective study aimed to examine the relationship between the complement 3/4 (C3/C4) ratio and the clinicopathologic changes and prognosis of patients with IgAN.Methods:A total of 397 patients with primary IgAN from January 2007 to December 2012 at the Chinese People’s Liberation Army General Hospital were included in this study. The correlation test and Chi-square test or one-way analysis of variance test were performed to evaluate the relationship between the C3/C4 ratio and other clinical-pathological factors. Propensity score matching and a multivariate Cox regression model were used to calculate the risk factors of renal outcome.Results:The median follow-up period was 75 months. During the follow-up period, 62 patients (15.6%) developed into the end-stage renal disease (ESRD). The C3/C4 ratio at baseline was associated with the level of serum creatinine (SCr), 24 h urinary protein excretion (24 h Upre), global glomerular sclerosis, and tubulointerstitial lesion. The level of SCr and 24 h Upre and the degree of chronic kidney injury were statistically different among groups defined by different C3/C4 ratio levels. The survival rates of patients among groups with different C3/C4 ratio levels were different. After propensity score matching, eighty-eight pairs of patients were successfully matched, and the C3/C4 ratio was an influencing factor for the patients’ outcome (hazard ratio 0.587, 95% confidence interval 0.329-0.880). Patients with a C3/C4 ratio <3.6 had a poorer outcome compared with the others (P = 0.002).Conclusions:IgAN patients with decreased C3/C4 ratio displayed significantly more severe clinical symptoms and chronic renal injury than patients with higher ratios. A low C3/C4 ratio could be a risk factor for patients developing to ESRD.
简介:摘要: 火电厂在实际运行的过程中,最容易发生故障的类型就是电气设备故障,基于此,本篇文章主要对电气设备故障以及实际的故障处理方法进行深入的探究和分析。
简介:摘要目的分析1个诺里病家系的致病基因变异,确定其遗传学病因。方法对先证者核心家系4名成员的DNA样本进行全外显子组检测,筛选变异位点,确定致病基因。通过Sanger测序对核心家系及7名其他家系成员进行验证。结果全外显子组检测及Sanger测序结果显示先证者及另外3例男性患者的NDP基因均存在c.361C>T(p.Arg121Trp)半合子错义变异,先证者母亲、外祖母和2个表妹均为c.361C>T杂合变异携带者,正常表型男性家系成员均未检测到该变异,符合X连锁隐性遗传病的特点。结论NDP基因c.361C>T错义变异是该诺里病家系的遗传学病因。
简介:AbstractBackground:Developing effective spinal cord repair strategies for spinal cord injury (SCI) is of great importance. Emerging evidence suggests that microRNAs (miRNAs) are closely linked to SCI recovery. This study aimed to investigate the function of miR-34c in the neuronal recovery in rats with SCI.Methods:A rat model with SCI was established. Differentially expressed miRNAs were identified by a microarray analysis. MiR-34c expression in rats was measured by reverse transcription quantitative polymerase chain reaction. Altered expression of miR-34c or C-X-C motif ligand 14 (CXCL14) was introduced in SCI rats to measure their roles in neuronal recovery. Western blot analysis was performed to determine the phosphorylation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription-3 (STAT3). Neuronal apoptosis in rat spinal cord tissues was detected. The concentrations of SCI recovery-related proteins thyrotropin releasing hormone (TRH), prostacyclin (PGI2), and ganglioside (GM) were evaluated by enzyme-linked immunosorbent assay. Data were analyzed using a t-test with a one-way or two-way analysis of variance.Results:Rats with SCI presented decreased grip strength (112.03 ± 10.64 vs. 17.32 ± 1.49 g, P < 0.01), decreased miR-34c expression (7 days: 3.78 ± 0.44 vs. 0.95 ± 0.10, P < 0.05), and increased CXCL14 expression (7 days: 0.61 ± 0.06 vs. 2.91 ± 0.27, P < 0.01). MiR-34c was found to directly bind to CXCL14. Overexpression of miR-34c increased grip strength (11.23 ± 1.08 vs. 31.26 ± 2.99 g, P < 0.01) and reduced neuronal apoptosis in spinal cord tissues (53.61% ± 6.07% vs. 24.59% ± 3.32%, P < 0.01), and silencing of CXCL14 also increased the grip strength (12.76 ± 1.13 vs. 29.77 ± 2.75 g, P < 0.01) and reduced apoptosis in spinal cord tissues (55.74% ± 6.24% vs. 26.75% ± 2.84%, P < 0.01). In addition, miR-34c upregulation or CXCL14 downregulation increased the concentrations of TRH, PGI2, and GM, and reduced phosphorylation of JAK2 and STAT3 in rats with SCI (all P < 0.01).Conclusion:The study provided evidence that miR-34c could promote neuronal recovery in rats with SCI through inhibiting CXCL14 expression and inactivating the JAK2/STAT3 pathway. This study may offer new insights into SCI treatment.