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简介：Dickinson’s ,the ,to 

简介：was one of the foremost authors in American literature. Emily Dickinson ’s poems,Death and eternity are the major themes in most of Emily Dickinson’s poems.,death and eternity. Death is a must-be-crossed bridge. She did not fear it

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简介：<正>Mr.President,itisnaturaltomantoindulgeintheillusionsofhope.Weareapttoshutoureyesagainstapainfultruth,andlistentothesongofthatsiren,tillshetransformsusintobeasts.Isthisthepartofwisemen,

简介：' by Emily Dickinson. The use of remembered images of the past to clarify infinite conceptions through the establishment of a dialectical relationship between reality and imagination,Emily Dickinson uses remembered images of the past to clarify infinite conceptions through the establishment of a dialectical relationship between reality and imagination,allowing the reader momentarily to glimpse a universe in which the seemingly distinct and discontinuous stages of existence are holistically implicated and purposed. NOTES [1.] Others who have written on Emily Dickinson's responses to death include Ruth Miller (The Poetry of Emily Dickinson [Middletown

简介：and ,the ,eternity. 

简介：' by Emily Dickinson. The use of remembered images of the past to clarify infinite conceptions through the establishment of a dialectical relationship between reality and imagination,an interpretation which allows the reader to evaluate "Death as either kind or malevolent" (130) and "Eternity" (131) as a "pleasant" place or realm of "nothingness" (132). [4. In The Rhetoric of American Romance (Baltimore摘要,a house seems as "A Swelling of the Ground" (18). Figuratively the poem may symbolize the three stages of life摘要

简介：Coloncancersdevelopadaptivemechanismstosurviveunderextremeconditionsanddisplayhallmarksofunlimitedproliferationandresistancetocelldeath.Thederegulationofcelldeathisakeyfactorthatcontri-butestochemoresistanceintumors.Inaphysiologicalcontext,balancebetweencellproliferationanddeath,andprotectionagainstcelldamagearefundamentalprocessesformaintaininggutepithelialhomeostasis.Themechanismsunderlyinganti-deathcytoprotectionandtumorresistanceoftenbearcommonpathways,andalthoughdistinguishingthemwouldbeachallenge,itwouldalsoprovideanopportunitytodevelopadvancedanti-cancertherapeutics.Thisreviewwilloutlinecelldeathpathways(i.e.,apoptosis,necrosis,andnecroptosis),anddiscusscytoprotectivestrategiesinnormalintestinalepitheliumanddeathresistancemechanismsofcolontumor.Incolorectalcancers,theintracellularmechanismsofdeathresistanceincludethedirectalterationofapoptoticandnecroptoticmachineryandtheupstreameventsmodulatingdeatheffectorssuchastumorsuppressorgeneinactivationandpro-survivalsignalingpathways.Theautocrine,paracrineandexogenousfactorswithinatumormicroenvironmentcanalsoinstigateresistanceagainstapoptoticandnecroptoticcelldeathincoloncancersthroughchangesinreceptorsignalingortransporteruptake.Therolesofcyclooxygenase-2/prostaglandinE2,growthfactors,glucose,andbacteriallipopolysaccharidesincolorectalcancerwillbehighlighted.Targetinganti-deathpathwaysinthecoloncancertissuemightbeapromisingapproachoutsideofanti-proliferationandanti-angiogenesisstrategiesfordevelopingnoveldrugstotreatrefractorytumors.

简介：Dickinson’s ,’s ,poets 

简介：' by Emily Dickinson. The use of remembered images of the past to clarify infinite conceptions through the establishment of a dialectical relationship between reality and imagination,Emily Dickinson uses remembered images of the past to clarify infinite conceptions through the establishment of a dialectical relationship between reality and imagination,allowing the reader momentarily to glimpse a universe in which the seemingly distinct and discontinuous stages of existence are holistically implicated and purposed. NOTES [1.] Others who have written on Emily Dickinson's responses to death include Ruth Miller (The Poetry of Emily Dickinson [Middletown

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简介：Programmedcelldeathplaysanimportantroleinmaintaininghomeostasisduringanimaldevelopment,andhasbeenconservedinanimalsasdifferentasnematoesandhumans.RecentstudiesofDrosophilahaveprovidedvaluadleinformationtowardourunderstandingofgeneticregulationofdeath.Differentsignalstriggerthenoveldeathregulatorsrpr,hid,andgrim,thatutilizetheevolutionarilyconservediapandarkgenestomodulatecaspasefunction.Subsequentremovalofdyingcellsalsoappearstobeaccomplishedbyconservedmechanisms.ThesimilaritybetweenDrosophilaandhumanincelldeathsignalingpathwaysillustratethepromiseoffruitfliesasamodelsystemtoelucidatekthemechanismsunderlyingregulationofprogrammedcelldeath.

简介：Uponencounteringtheantigen(Ag),theimmunesystemcaneitherdevelopaspecificimmuneresponseofenteraspecificstateofunresponsiveness,tolerance.TheresponseofBcellstotheirspecificAgcanbeactivationandproliferation,leadingtotheimmuneresponse,oranergyandactivation-inducedcelldeath(AICD),leadingtotolerance.AICDinBlymphocytesisahighlyregulatedeventinitiatedbycrosslinkingoftheBcellreceptor(BCR).BCRengagementinitiatesseveralsignalingeventssuchasactivationofPLCγ,Ras,andPI3K,whichgenerallyspeaking,leadtosurvival.However,intheabsenceofsurvivalsignals(CD40orIL-4Rengagement),BCRcrosslinkingcanalsopromoteapoptoticsignaltransductionpathwayssuchasactivationofeffectorcaspases,expressionofpro-apoptoticgenes,andinhibitionofpro-survivalgenes.ThecomplexinterplaybetweensurvivalanddeathsignalsdeterminestheBcellfateand,consequently,theimmuneresponse.

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简介：Twomajorapoptosispathwayshavebeendefinedinmammaliancells,theFas/TNF-R1deathreceptorpathwayandthemitochondriapathway.TheBcl-2familyproteinsconsistofbothanti-apoptosisandpro-apoptosismembersthatregulateapoptosis,mainlybycontrollingthereleaseofcytochromecandothermitochondrialapoptoticevents.However,deathsignalsmediatedbyFas/TNF-R1receptorscanusuallyactivatecaspasesdirectly,bypassingtheneedformitochondriaandescapingtheregulationbyBcl-2familyproteins.Bidisanovelpro-apoptosisBcl-2familyproteinthatisactivatedbycaspase8inresponsetoFas/TNF-R1deathreceptorsignals.ActivatedBidistranslocatedtomitochondriaandinducescytochromecrelease,whichinturnactivatesdownstreamcaspases.Suchaconnectionbetweenthetwoapoptosispathwayscouldbeimportantforinductionofapoptosisincertaintypesofcellsandresponsibleforthepathogenesisofanumberofhumandiseases.

简介：本文选自《时代》周刊。读者阅后可从一个侧面窥测发达的资本主义社会存在的畸形问题。

简介：AbstractGamete production is essential for mammalian reproduction. In the ovaries, the primordial follicle, which is the basic reproductive unit, is formed either perinatally or during the second pregnancy stage in humans. However, some oocytes die before the establishment of the primordial follicle pool. Consequently, it is essential to uncover how the size of the primordial follicle pool is determined and how the programmed cell death of oocytes is performed under potential surveillance. According to recent studies, the fate of oocytes in the fetal ovary seems to be determined by different protective strategies through the timely control of apoptosis or autophagy. In this review, we discuss at least three oocyte-derived protective biomarkers, glycogen synthase kinase 3 beta, X-linked inhibitor of apoptosis, and Lysine-specific demethylase 1 (also known as KDM1A), responsible for surveilling the developmental quality of fetal oocytes to coordinate primordial follicle formation in the fetal ovary. This review contributes to a better understanding of the secrets of the female reproductive reserve under physiological conditions.