简介：Next-generationsequencing(NGS)isanewtechnologyusedforDNAandRNAsequencingandvariant/mutationdetection.NGScansequencehundredsandthousandsofgenesorwholegenomeinashortperiodoftime.Thesequencevariants/mutationsdetectedbyNGShavebeenwidelyusedfordiseasediagnosis,prognosis,therapeuticdecision,andfollowupofpatients.Thecapacityofitsmassiveparallelsequencingoffersnewopportunitiesforpersonalizedprecisionmedicine.

简介：Supercontinuum(SC)generationhasattractedasignificantscientificinterestinthepastdecadesduetoitspromisingapplicationscoveringthefieldsofmetrology,spectroscopy,defense,aswellasmedicaltreatments.Todate,researchersaredevotedtoimprovingthespectralwidthandflatnessofSCgenerationbyusingspecialtyopticalfibers.Theflatnessofthespectrumisofimportancebecauseitcanimprovetheaccuracyofmeasurementinpracticalapplications.ThispapersummarizesthetheoryofSC,thestateoftheartofflatSCgenerationusingopticalfiberincludingphotoniccrystalfibers,softglassfibersaswellasgermania-dopedfibers,andsuggeststhefutureresearchdirectionofflatSClightsource.

简介：High-dimensionalentanglementisavaluableresourceforsecureandefficientquantuminformationprocessing.Amajorchallengeforpracticaluseofmultidimensionalquantumsystemsistheestablishmentofcontrolsoverarbitrarysuperpositionstatesinrealisticconditions.Thisworkdemonstratesspatiallyentangledphotonpairspropagatingthroughtwoseparatefour-coreopticalfiberswiththeamplitudesandphasesofthesuperpositionbeingindependentlycontrollable.Usingquantumstateanalyzersthatcandetectarbitrarymulticoresuperpositionstates,Bell-typeCGLMPinequalitiesintwo,three,andfourdimensionsaredirectlytested.Enhancedviolationoftheinequalitybyslightnonmaximalityofentanglementisalsodemonstrated.

简介：Weproposeahumanavatarrepresentationschemebasedonintrinsiccoordinates,whichareinvarianttoisometryandinsensitivetohumanposechanges,andanefficientposetransferalgorithmthatcanutilizethisrepresentationtoreconstructahumanbodygeometryfollowingagivenpose.Suchaposetransferalgorithmcanbeusedtocontrolthemovementofanavatarmodelinvirtualrealityenvironmentsfollowingauser'smotioninrealtime.Ourproposedalgorithmconsistsofthreemainsteps.First,werecognizetheuser'sposeandselectatemplatemodelfromthedatabasewhohasasimilarpose;then,theintrinsicLaplacianoffsetsencodedinlocalcoordinatesareusedtoreconstructthehumanbodygeometryfollowingthetemplatepose;finally,themorphingbetweenthetwoposesisgeneratedusingalinearinterpolation.Weperformexperimentstoevaluatetheaccuracyandefficiencyofouralgorithm.Webelieveourproposedsystemisapromisinghumanmodelingtoolthatcanbeusedingeneralvirtualrealityapplications.

简介：Wereportonadiode-end-pumpedhigh-powerandhigh-energyNd:YAGsingle-crystalfiberlaserat1834nm.Two808nmdiodesinjectingabout58WpumppowerintotheNd:YAGfiberhavegenerated3.28Wcontinuouswaveand1.66WCr:ZnSe-basedpassivelyQ-switchedlasers.Slopeefficiencieswithrespecttopumppowersare8.7%forthecontinuous-wavelaserand4.9%fortheQ-switchedlaser.Theextractedmaximumpulseenergyisabout266.9μJ,andthecorrespondingmaximumpulsepeakpoweris2.54kW.Theseperformancesgreatlysurpasspreviousresultsregardingthisspecificlaseremissionbecausethelasergainmediumintheformoffibercansignificantlymitigatethermallyinducedpowersaturationthankstoitssignificantlyreducedthermallensingeffect.Single-crystalfiberlasersshowgreatpotentialforhighaveragepower,pulseenergy,andpeakpower.

简介：Entangledphotonsarethefundamentalresourceinquantuminformationprocessing.Howtoproducethemefficientlyhasalwaysbeenamatterofconcern.HereweproposeanewwaytoproducecorrelatedphotonsefficientlyfrommonolayerWS2basedonboundstatesinthecontinuum(BICs).TheBICsofradiationmodesinthemonolayerWS2arerealizedbydesigningthephotoniccrystalslab-WS2-slabstructure.Thegenerationefficiencyofcorrelatedphotonpairsfromsuchastructurehasbeenstudiedbyusingarigorousquantummodelofspontaneousparametricdown-conversionwiththeplanewaveexpansionmethod.ItisfoundthatthegenerationefficiencyofcorrelatedphotonpairsisgreatlyimprovedifthesignalandidlerfieldsarelocatedattheBICsdeterminedbytheinversescatteringmatrixofthestructure.Thisisincontrasttotheparametricdown-conversionprocessfortheenhancedgenerationofnonlinearwavesifthepumpfieldislocatedattheBICsdeterminedbythescatteringmatrixofthestructure.Thegenerationrateofthecorrelatedphotonpairscanbeimprovedby7ordersofmagnitudeinsomedesignedstructures.Thegeneratedquantumsignalsaresensitivetothewavelengthandexhibitnarrowedrelativelinewidth,whichisverybeneficialforquantuminformationprocessing.

简介：Tomeettherequirementsofelectronicvehicles(EVs)andhybridelectricvehicles(HEVs),thehighenergydensityLiNi0.8Co0.15Al0.05O2(NCA)cathodeandSi–Canodehaveattractedmoreattention.HerewereportthethermalbehaviorsofNCA/Si–Cpouchcellduringthecharge/dischargeprocessesatdifferentcurrentdensities.ThetotalheatgenerationsarederivedfromthesurfacetemperaturechangeduringelectrochemicalLi+insertion/extractioninadiabaticsurrounding.Thereversibleheatisdeterminedbytheentropiccoefficients,whicharerelatedwithopen-circuitvoltageatdifferenttemperatures;whiletheirreversibleheatisdeterminedbytheinternalresistance,whichcanbeobtainedviaV–Icharacteristic,electrochemicalimpedancespectroscopyandhybridpulsepowercharacterization(HPPC).Duringtheelectrochemicalprocess,thereversibleheatcontributeslessthan10%tototalheatgeneration;andtheheatgeneratedinchargeprocessislessthanthatindischargeprocess.Theresultsofthermalbehaviorsanalysesareconducivetounderstandingthesafetymanagementandpavingthewayforbuildingareliablethermalmodelofhighenergydensitylithiumionbattery.

简介：Bismuth(Bi)-dopedphotonicmaterials,whichexhibitbroadbandnear-infrared(NIR)luminescence(1000–1600nm),areevolvingintointerestinggainmedia.However,thetraditionalmethodshaveshowntheirlimitationsinenhancingBiNIRemission,especiallyinthemicroregion.Consequently,thetypicalNIRemissionhasseldombeenachievedinBi-dopedwaveguides,whichhighlyrestrictstheapplicationofBi-activatedmaterials.Here,superbroadbandBiNIRemissionisinducedinsituinstantlyinthegratingregionbyafemtosecond(fs)laserinsideborosilicateglasses.Aseriesofstructuralandspectroscopiccharacterizationsaresummonedtoprobethegenerationmechanism.AndweshowhowthisnovelNIRemissioninthegratingregioncanbeenhancedsignificantlyanderasedreversibly.Furthermore,wesuccessfullydemonstrateBi-activatedopticalwaveguides.TheseresultspresentnewinsightsintoBi-dopedmaterialsandpushthedevelopmentofbroadbandwaveguideamplification.

简介：Wedemonstrateapassivelymode-lockedall-fiberlaserincorporatingapieceofgraded-indexmultimodefiberasamode-lockingmodulatorbasedonanonlinearmultimodalinterferencetechnique,whichgeneratestwotypesofcoexistinghigh-energyultrashortpulses(i.e.,theconventionalsoliton(CS)andthestretchedpulse(SP))TheCSwithpulseenergyashighas0.38nJisobtainedatthepumplevelof130mW.Whenthepumpincreasesto175mW,thehigh-energySPoccursatasuitablenonlinearphasebiasanditspulseenergycanreach4nJata610mWpump.ThepulsedurationsofthegeneratedCSandSPare2.3psand387fs,respectively.Thetheoryofnonlinearfiberoptics,single-shotspectralmeasurementbythedispersiveFourier-transformtechnique,andsimulationmethodsbasedontheGinzburg–LandauequationareprovidedtocharacterizethelaserphysicsandrevealtheunderlyingprinciplesofthegeneratedCSandSP.Aroguewave,observedbetweentheCSandSPregions,mirrorsthelaserphysicsbehindthedynamicsofgeneratingahigh-energySPfromaCS.Theproposedall-fiberlaserisversatile,cost-effectiveandeasytointegrate,whichprovidesapromisingsolutionforhigh-energypulsegeneration.

简介：Next-generationsequencing(NGS)technologyiscapableofsequencingmillionsorbillionsofDNAmoleculessimultaneously.Therefore,itrepresentsapromisingtoolfortheanalysisofmoleculartargetsfortheinitialdiagnosisofdisease,monitoringofdiseaseprogression,andidentifyingthemechanismofdrugresistance.OnbehalfoftheTumorBiomarkerCommitteeoftheChineseSocietyofClinicalOncology(CSCO)andtheChinaActionableGenomeConsortium(CAGC),thepresentexpertgroupherebyproposesadvisoryguidelinesonclinicalapplicationsofNGStechnologyfortheanalysisofcancerdrivergenesforprecisioncancertherapy.Thisgroupcomprisesanassemblyoflaboratorycancergeneticists,clinicaloncologists,bioinformaticians,pathologists,andotherprofessionals.Aftermultipleroundsofdiscussionsandrevisions,theexpertgrouphasreachedapreliminaryconsensusontheneedofNGSinclinicaldiagnosis,itsregulation,andcompliancestandardsinclinicalsamplecollection.Moreover,ithaspreparedNGScriteria,thesequencingstandardoperationprocedure(SOP),dataanalysis,report,andNGSplatformcertificationandvalidation.

简介：Weexperimentallydemonstratedatypeoftunableandswitchableharmonich-shapedpulsegenerationinathulium-dopedfiber(TDF)laserpassivelymodelockedbyusinganultralongnonlinearopticalloopmirror.Thetotalcavitylengthwas~3.03km,thelongesteverbuiltforaTDFlasertoourbestknowledge,whichresultedinanultralargeanomalousdispersionover-200ps~2aroundtheemissionwavelength.Theproducedh-shapedpulsecanoperateeitherinafundamentalorinahigh-orderharmonicmode-locking(HML)statedependingonpumppowerandintra-cavitypolarizationstate(PS).Thepulseduration,nomatteroftheoperationstate,wastunablewithpumppower.However,pulsebreakingandself-organizingoccurred,resultinginhigh-orderHML,whenthepumppowerincreasedaboveathreshold.Atafixedpumppower,theorderofHMLwasswitchablefromonetoanotherbymanipulatingthePS.Switchingfromthe8thuptothe48thorderofHMLwasachievedwithafixedpumppowerof~4.15W.OurresultsrevealedthedetailedevolutionandswitchingcharacteristicsoftheHMLandindividualpulseenvelopewithrespecttoboththepumppowerandPS.Wehavealsodiscussedindetailthemechanismsofboththeh-shapedpulsegenerationandtheswitchingofitsHML.Thiscontributionwouldbehelpfulforfurtherin-depthstudyontheunderlyingdynamicsoflong-durationparticular-envelopepulseswithultralargeanomalousdispersionandultralongroundtriptime.

简介：Ultrafastfiberlasersareingreatdemandforvariousapplications,suchasopticalcommunication,spectroscopy,biomedicaldiagnosis,andindustrialfabrication.Here,wereportthehighlystablefemtosecondpulsegenerationfromaMXenemode-lockedfiberlaser.Wehavepreparedthehigh-qualityTi3C2Txnanosheetsviatheetchingmethod,andcharacterizedtheirultrafastdynamicsandbroadbandnonlinearopticalresponses.Theobviousintensity-andwavelength-dependentnonlinearresponseshavebeenobservedandinvestigated.Inaddition,ahighlystablefemtosecondfiberlaserwithsignal-to-noiseratioupto70.7dBandcentralwavelengthof1567.3nmhasbeendelivered.Thestudymayprovidesomevaluabledesignguidelinesforthedevelopmentofultrafast,broadbandnonlinearopticalmodulators,andopennewavenuestowardadvancedphotonicdevicesbasedonMXenes.