简介：Thequestforneuroprotectivedrugstoslowtheprogressionofneurodegenerativediseases(NDDs),includingAlzheimer'sdisease(AD),Parkinson'sdisease(PD),andHuntington'sdisease(HD),hasbeenlargelyunrewarding.Preclinicalevidencesuggeststhatrepurposingquetiapine,lithium,valproate,fluoxetine,donepezil,andmemantineforearlyandpre-symptomaticdisease-modificationinNDDsmaybepromisingandcanspareregulatorybarriers.Theliteratureofthesepsychotropicsinearlystageandpre-symptomaticAD,PD,andHDisreviewedandpropitiousfindingsfollow.Mildcognitiveimpairment(MCI)phaseofAD:salutaryhumanrandomizedcontrolledtrialfindingsforlow-doselithiumand,inselectedpatients,donepezilawaitreplication.Pre-symptomaticAD:humanepidemiologicaldataindicatethatlithiumreducesADrisk.Animalmodelstudies(AMS)revealencouragingresultsforquetiapine,lithium,donepezil,andmemantine.EarlyPD:valproateAMSfindingsshowpromise.Pre-symptomaticPD:lithiumandvalproateAMSfindingsareencouraging.EarlyHD:uncontrolledclinicaldataindicatenon-progressionwithlithium,fluoxetine,donepezil,andmemantine.Pre-symptomaticHD:lithiumandvalproateareauspiciousinAMS.Manyotherpromisingfindingsawaitingreplication(valproateinMCI;lithium,valproate,fluoxetineinpre-symptomaticAD;lithiuminearlyPD;lithium,valproate,fluoxetineinpre-symptomaticPD;donepezilinearlyHD;lithium,fluoxetine,memantineinpre-symptomaticHD)arereviewed.Dose-andstage-dependenteffectsareconsidered.Suggestionsforsignal-enhancementinhumantrialsareprovidedforeachNDDstage.

简介：六新光学地活跃并且flame-retardant(amide-imide)poly，在主要的链作为一个flame-retardant单位包含磷化氢氧化物一半的s白族5a鈥?f从六chiralN的直接polycondensation反应被综合，有二度(3-aminophenyl)的N鈥?(pyromellitoyl)-bis-L-amino酸3a鈥?f在中等在于的苯基磷化氢氧化物4N-methyl-2-pyrrolidone(NMP)，triphenyl亚磷酸盐(TPP)，钙氯化物(CaCl2)和pyridine。生产的聚合反应一系列光学地活跃poly(amide-imide)有好产量和0.34鈥?.70dLg的好固有的粘性的s?1。结果的聚合物充分借助于FTIR和1H-NMR光谱学，胶化浸透层析(GPC)，元素的分析，固有的粘性和溶解度测试被描绘。热性质和白族5a鈥?f的flame-retardant行为被调查使用热gravimetric分析(TGA和DTG)并且限制氧索引(LOI)。热分析(TGA和DTG)获得的数据表明这些聚合物显示出好热稳定性。而且，在TGA的高字符产量和好LOI值显示产生聚合物能够展出好火焰retardant性质。N，N鈥?(pyromellitoyl)-bis-L-amino酸3a鈥?f被pyromelliticdianhydride(1,2,4,5-benzenetetracarboxylicacid-1,2,4,5-dianhydride)的冷凝作用反应在量的收益准备1与L丙氨酸2a，L缬氨酸2b，L白氨酸2c，L异白氨酸2d，L苯基丙氨酸2e和L-2-aminobutyric在醋酸的酸2f答案。关键词光学地活跃-Flame-retardant聚合物-Poly(amide-imide)s-限制氧索引

简介：Thispaperconstructedportfoliosaccordingtothegrowthratesandtheirstabilityoffirm'stotalstockholders'equitypershareandnetincomepershare,usingallthefirms'informationofShanghaiA-sharemarket.Wefoundthatthemarketexhibitssomeoverreactiontothegrowthraieoffirm'snetincomepershare,andisn'tsensitivetothestabilityoffirm'sgrowthrates.

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简介：RelationsbetweenEuropeandAmericahavealwaystakenanimportantpositioninmajorpowerrelations.NATO,formedduringtheColdWar,wasuniversallyseenasthemostsuccessfulallianceinhistory.Inthepost-ColdWarmilitaryactionssuchasthefirstGulfWar,KosovowarandAfghanistanwar,EuropeannationsandAmeri

简介：TheU.S.-drivenTPPhascaughttheattentionoftheregionandisbringinguncertaintytoEastAsianeconomicintegration.China,theU.S.andJapanhavetakendifferentpositionsontheTPPitself.TheU.S.isactivelyparticipatinginTPPnegotiationsandtryingtodominateit.JapanregardstheTPPasatoolwithwhichitcanfurtherexploremarketsaswellasstrengthenitsrelationshipwiththeU.S..ChinaiscurrentlyassessingtheU.S.shiftineconomicstrategytowardsEastAsiaandthepotentialimpactsofTPPexpansion.

简介：NatsumeSōseki(1867-1916)sufferedfromcyclicmentaldepressionsthroughhislife,anditwaswhenhewasinthestateofthemostterribleonethathestartedhiscareerasawriterbywritingIAmaCat(1905-1906).TherearesomeevidencebyhiswifeandfriendsthatSōseki’sconditionofdiseasedramaticallyimprovedduringitsserializationonamagazine,andthewriterhimselfadmitedhumorouslyintheprefaceofotherworkthatitwashisdepressionandmaniathatenabledhimtoproduceIAmaCatandotherearlyworks.Thispaperaimsatdescribingtheprocesshowhisactofnarratinghadtherapeuticeffectsonhisstateofmindfocusingontheconstructionofcomplicitousrelationshipbetweenanimpliedauthorandreadersintheworkbytheuniquefunctionsofthefirst-‘person’narrator:ACat.Amongothers,IwillconsidertheinfluenceofLaurenceSterne’sTristramShandy(1759-1767),whichSōsekiintroducedtoJapanforthefirsttime,bydiscussingthefrequentuseofmetalepsisthatthetwoworkshaveincommon.

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简介：力远作为业内知名穿线机品牌,多年来一直以优质的产品和专业的售后服务,在业内赢得了良好的口碑,在2011年成都体博会成功推出了S11穿线机之后,今年在北京体博会又成功推出了两款新型S系列电脑穿线机。为此本期特别推荐给大家。

简介：学校变革是教育改革的突破口与落脚点。大学与中小学在政府的支持保障或促成下进行合作的U-G-S模式具有重要意义,然而其局限也很明显:投入多、见效慢,理论研究者与实践者交流不畅。U-G-S-S模式承继了U-G-S模式的优势,并进行了突破:强调参与学校变革行动的中小学的数量为两所及以上,且学校教育质量是异质的,既有城市优质学校,也有城郊薄弱学校或乡村学校;U-G-S-S四方主体平等互动、各司其职。个案研究表明,U-G-S-S模式可以通过制度建构、任务驱动和文化营造促进各参与学校的整体发展,促进城乡义务教育均衡发展。U-G-S-S模式成功的三个主要要素:文化异质交融、知识多维共享、理论实践有机结合。

简介：令Vn=span{1,2,…,n},设函数f∈Lp[E,μ],1≤p<∞,在点p处定义一个最佳Lp逼近算子τ∫（p）。记Nf（p）=∥f-τ∫（p）∥p=inf/Q∈Vn∥f-Q∥po本文证明了Nf（p）/[μ（E）]l/p是p的单调增加且有界的函数。如果f∈L∞[E,μ],则存在τ∫（∞）∈Vn,使得∥f-τ∫（∞）∥∞=inf/Q∈Vn∥f-Q∥∞,并且给出了最佳逼近值。

简介：GivenacontinuousfunctionfdefinedontheunitcubeofRnandaconvexfunctiont,t（0）-0,t（x）>0,forx>0,weprovethatthesetofbestLt-approximationsbymonotonefunctionshasexactlyoneelementft,whichisalsoacontinuousfunction.Moreoverifthefamilyofconvexfunctions{t}t>0convergesuniformlyoncompactsetstoafunction0,thenthebestapproximationft→f0uniformly,ast→0,wherefoisthebestapproximationoffwithintheOrliczspaceL0Thebestapproxima-tions{ft}areobtainedaswellasminimizingintegralsortheLuxemburgnorm

简介：长城显示器2008年进入三甲并非偶然，而是必然，即便遇到全球性的经济危机，但是长城显示器前进的脚步并没有停止，逆市上涨的秘密是什么？不外乎两个条件：过硬的产品，低廉的价格。

简介：AcharacteristicoftheextendedCarlesonmeasureexpressedbythederivativesofLpfunctionsinRn+1+isobtained.

简介：让Sq-1，q≥2，联合起来的范围的表面在欧几里德几何学的spaceRq，f(x)∈Lp(Sq-1)，f(x)≥0，f吗？0，1≤p≤+∞。然后，它在现在的纸被证明有顺序≤N和经常的C>的球形的泛音PN(x)0以便‖f-1/P_N‖L_p≤Cω(f,N~(-1))Lp,在哪儿ω(f，吗δ)Lp=sup_(0S_t(f，μ)='1/(|S~(q-2)|sin~(2λ)t)∫'连续性ofmoduli‖S_t(f)-f‖Lp>

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简介：上汽大众全新途安L，横向化的设计元素、丰富的层次感，以及动感的细节处理，