简介:
简介:AmodelofcrosslinkerunbindingisimplementedinahighlycoarsegrainedgranularmodelofF-actincytoskeleton.WeemploythisspecificgranularmodeltostudythemechanismsofthecompressiveresponsesofF-actinnetworks.ItisfoundthatthecompressiveresponseofF-actincytoskeletonhasdependencyonthestrainrate.TheevolutionofdeformationenergyinthenetworkindicatesthatcrosslinkerunbindingeventscaninducetheremodellingofF-actincytoskeletoninresponsetoexternalloadings.TheinternalstressinF-actincytoskeletoncanefficientlydissipatewiththehelpofcrosslinkerunbinding,whichcouldleadtothespontaneousrelaxationoflivingcells.