简介：ObjectiveTorecordtheendocochlearpotential(EP)andcalculatepotassiumconcentration[K+]inMinipigcochleae.MethodsWeusedmulti-barreledelectrodestomeasuretheEPandthepotential,[K+].EPandpotassiumelectroderecordingweremadein9cochleaefrom5minipigstogetnormalEPvalues.ResultsTheaverageEPvalueinthecochleafromtheminipigswas77.3±14mV.Theaverage[K+]fortheminipigswas147.1±13mM.ConclusionsTheEPandpotential,[K+]inminipigsarelowerthaninthehumanandrodents.ThismaybethereasonwhyporcineABRthresholdsareslightlyhigherthanhumansandrodents.

简介：Objective:Todescribeaprotocolforrecordingelectricalpotentialsfromthescalamedia,saccule,andutricleinmice.Method:CBA/Jmicewereusedandpotentialswererecordedwithglasselectrodesinsertedthroughthebasilarmembraneusingapatchclampsystem.Results:Restingpotentialsweresuccessfullyrecordedfromthescalamedia,sacculeandutricleusingdescribedprotocols.Conclusions:Withthemethoddescribed,onecanmeasurerestingpotentialsfromthescalamedia,sacculeandutricle,aswellascochlearmicrophonics(CM)andevenauditorynervecompoundactionpotentials(CAP),inasinglemouse.

简介：Objective:Electrocochleography(ECochG)isvaluabletodiagnoseMeniere'sdiseaseobjectively.TheaimofthepresentstudywastoprovidepreliminarynormativedataforECochGamongAsianadults.Theinfluencesofethnicity(MalayversusChinese)andgenderonECochGresultswerealsostudied.Methods:Twenty-twoMalayadults(10menand12women)andtwentyChineseparticipants(10menand10women)agedbetween20and49yearsparticipatedinthisstudy.ExtratympanicECochG(ET-ECochG)wasrecordedaccordingtostandardnon-invasiveprocedure.Summatingpotential(SP)amplitude,actionpotential(AP)amplitudeandSP/APratiowereanalyzedaccordingly.Results:ET-ECochGresultswerefoundtobecomparablebetweenleftandrightears(p>0.05).NonotabledifferencesinET-ECochGresultswerefoundbetweenMalayandChinesegroups(p>0.05).NosignificantinfluenceofgenderonET-ECochGoutcomeswasalsonoted(p>0.05).ThederivednormativedataforAsianadults(84ears)areconsistentwithpreviousreports.Conclusion:ThepresentstudyprovidespreliminarynormativedataforET-ECochGamongAsianadults.TheECochGcomponentsdonotappeartobeinfluencedbyeitherethnicityorgender.ThederivednormativedatacanbeusedforclinicalapplicationsandasthereferenceforfuturestudiesinvolvingAsianpopulation.