简介：Afacileone-potsynthesisofα-cyclodextrin-basedpolyrotaxane(PR)inaqueoussolutionisreported,wherethepeptideglutathionewasusedastheend-cappingagentandthethiol-eneMichaeladditionwasusedastheend-cappingreaction.Bothpolyrotaxaneswithlowthreadingratioandhighthreadingratioweresuccessfullyobtained.Incontrasttotheconventionallyusedmultiple-stepsynthesismethodsandhydrophobicendcappers,thisone-potaqueoussynthesisaswellasthebiocompatibilityoftheend-cappingagentcouldresultinamuchmorebiocompatiblePRtobeusedasbiomaterials.

简介：

简介：α-andβ-cyclodextrinsconsistingofsixandsevenglucoseresiduesrespectively,havelipophiliccavitieswithdifferentinnerdiameters.Theyformhost-guestinclusioncomplexeswithhydrophobicorganicandorganometallicguestmoleculesinaqueoussolution.Thesehost-guestcomplexeshaveprovedtobeexcellentmodelsystemsforstudyingthenatureofnoncovalentbondingforcesinaqueousmedia.TheyhaveprovidedvaluableinsightsintothehydrophobiceffectandLondondispersionforcesandaregoodmodelforunderstandingthespecificityofenzymesubstrateinteractions[1]Evidencefortheformationofinclusioncomplexeshavebeenprovidedfromcalovimetrictitration[2]NMR[33],circulardichroism[4],UV[1]andfluorescencespectra[5]andconductometricmethod[6]etc.Herewereportanewfluorimetricmethodforastudyonthereactionofthehost-guestinclusioncomplexesofcyclodextrinwithphenols.Dissociationconstants(Kd)oftheinclusioncomplexesofsomephenolswithα-β-cyclodextrinareestimatedbasedonthevariationofthefluorescentintensityandmodifiedHarad'equations.

简介：Thesupramolecularinclusioncompoundofβ-cyclodextrin(β-CD,host)with(η5-cyclopentadienyl)tricarbonylmanganese[MnCp(CO)3,guest]wasobtainedinacrystallinestate.Thehost-guestcompoundisthermallystableanddonotliberatetheguestonheatingat100$invacuum.Itwascharacteriedbyelementalanalysis,1HNMR,differentialscanningthermal(DSC)analysisandTLC.ContinueousvariationplotbyNMRmethodshowsthatβ-CDformed1:1inclusioncompoundwithMnCp(CO)3.Onthebasisof1HNMRspectraandthemodelbuildingwithCoreyPaulingKoltum(CPK)models,themostprobableinclusionmodeisproposed.

简介：在这个工作，最佳的clathration条件为阿司匹林的准备被调查--cyclodextrin(毒蛇--CD)实验(雌动物)的包括建筑群使用设计方法论。A3水平，有17试验性的跑的一个总数的3因素Box-Behnken设计被使用。毒蛇--CD包括建筑群被浸透的答案方法准备。对嵌入的率的影响被调查，包括到毒蛇，clathration温度和clathration时间，和变量被发现是0.82的如此的三测试的最佳值的CD的臼齿的比率，49吗？？

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简介：Anureaadsorbentwithanaldostructurewasobtainedbytheoxidationofacrosslinkedβ-cyclodextrinpolymer.Thehighestureaadsorptioncapacityreached56.7mg/gin0.05Maqueousphosphatebuffer37℃andpH=7.4,anddecreaseto4.8mg/gininaqueoushumanserumalbumin.Thecompositeadsorbentwaspreparedbytheoxidationofacrosslinkedβ-cyclodextrinanddialyticmembrane.Itwasfoundthatthecompositeadsorbenthasahigherureaadsorptionselectivityandcapacitycomparedtothatoftheoxidationofacrosslinkedβ-cyclodextrinadsorbentwhenureaisinaqueoushumanserumalbumin.

简介：Anα-cyclodextrin(α-CD)incorporatedcarbonnanombe(CNT)-coatedelectrodewasfabricatedandappliedtothesimultaneousdeterminationofdopamine(DA)andepinephrine(EP).Ithasbeenfoundthatthemodifiedelectrodeshowsstrongcatalyticeffectsontheelectro-separationofDAandEP,andthecathodicpotentialdifferencebetweenDAandEPisabout390mV.ThereducingpeakcurrentisproportionaltoDAandEPconcentrationsintherangeof2.0×10^-6-1.0×10^-3and1.0×10^-6-1.0×10^-3mol·L^-1,respectively.Theirdetectionlimitscanreach1×10^-6and5×10^-7mol·L^-1,respectively.Becausetheoxidationofascorbicacid(AA)isanirreversiblereactioninα-CD/CNTfilm,theinterferenceofAAindeterminationofDAandEPiseliminated.

简介：Thispaperpresentedaninterestingnanoparticle-baseddrugdeliverysystemwithmorphologytransitionbehaviordependingonthecontentofexposedPEGchainontheparticlesurface,whichisadjustablebyadditionofdifferentamountofcyclodextrin(a-CD).Theeffectofa-CDinclusiontotheself-assemblybehaviorofmethoxypolyethyleneglycol(mPEG)graftedchitosan(CS)wasstudied.TheresultsshowedthatthemPEGgraftedchitosan(mPEG-[9_TD$IF]g-CS)formsself-assemblednanoparticleswitheithermicelleorhollowspheremorphologydependingontheratioofa-CDtomPEG,ascharacterizedbyatomicforcemicroscopy(AFM),transmissionelectronmicroscopy(TEM),andX-raydiffraction(XRD).Theirsizesandzetapotentialincreasedfrom257.6nmto768.2nmandfrom+4.5mVto+11.6mV,respectively,withtheincreasingamountofa-CD.Thecorrelationbetweenzetapotentialandparticlesizeofa-CD/mPEG-[9_TD$IF]g-CSnanoparticlesindicatedvariedPEGdensityonsurfaceofnanoparticles.Basedontheaboveexperimentalobservations,alikelymechanismforthemorphologicaltransitionoftherod-coilgraftcopolymermPEG-[9_TD$IF]g-CSwasproposed.

简介：ＤｉｍｅｒｉｚａｔｉｏｎＣｏｎｓｔａｎｔＤｅｔｅｒｍｉｎａｔｉｏｎｏｆ６－Ｏ－Ｂｅｎｚｏｙｌ－β－ＣｙｃｌｏｄｅｘｔｒｉｎｉｎＡｑｕｅｏｕｓＳｏｌｕｔｉｏｎ.ＤｉｍｅｒｉｚａｔｉｏｎＣｏｎｓｔａｎｔＤｅｔｅｒｍｉｎａｔｉｏｎｏｆ６－Ｏ－Ｂｅｎｚｏｙｌ?..

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简介：Apartiallysubstitutedβ-cyclodextrinchiralstationaryphasewaspreparedbythereactionofphenylisocyanate.TheenantiomersofaseriesofO,O-diethyl(p-methylbenzenesulfonamido)-aryl(oralkyl)-methylphos-.phonateswerestudiedonthepreparedphenylcarbamatederivativeβ-cyclodextrinbondedphaseandacommercial(S)-(.+)-l-(l-naphthyl)ethylcarbamatederivativeβ-cyclodextrinbondedphaseonnormalphasechromato-graphiccondition.Resultsshowthatthepreparedphenylcarbamatederivativeβ-cyclodextrinbondedphasehasbetterenantiomericselectivitytotheseriesofcompounds.Achiralrecognitionmechanismwassuggestedfortheseparationofthesenovelorganicphosphorusenantiomers.

简介：￣１ＨＡＮＤ￣（１３）ＣＮＭＲＳＴＵＤＹＯＦＩＮＣＬＵＳＩＯＮＣＯＭＰＬＥＸＡＴＩＯＮＯＦＤＳＳＷＩＴＨβ－ＣＹＣＬＯＤＥＸＴＲＩＮ￥ＱｉｎｇＸｉａｎｇＧＵＯ；ＴａｎＲＥＮ；ＺｉＺｈｏｎｇＬＩａｎｄＹｏｕＣｈｅｎｇＬＩＵ（ＮａｔｉｏｎａｌＬａｂｏｒａ...

简介：Anovelβ-cyclodextrin(β-CD)derivativebearingdiethanolaminemoietywassynthesizedbyaconvenientmethodwith63%yield,andthenewhostcompoundwascharacterizedby(13)~C-NMR,FT-IRspectraetc,

简介：在现在的学习，我们执行了-cyclodextrin的合成(用微波的-CD)functionalized金牌nanoparticles(AuNPs)帮助了在碱的媒介加热方法。CD的稳定的分散稳定的AuNPs在10.5的优化pH被获得。在这pH珍视CD的第二等的氢氧根组显示出的deprotonated向从而导致AuNP聚集的Pb2+离子的最高的chelating亲密关系。Pb2+在-CD-AuNP导致了聚集答案被比色的反应和紫外力的光谱学监视。TEM，DLS和FTIR分析被执行证实Pb2+离子在碱的条件下面导致了-CD-AuNPs的聚集行为。而且当时，在试验性的pH，向Pb2+离子的-CD-AuNP系统的反应是选择的与另外的介入的金属阳离子相比。

简介：Anumberofnaphthalenedonorcompoundsthatpossessanadamantanaminebindingmoietyandan(OCH2CH2)n(nn1,2,3,4,6,8)spacerweresynthesized.Thefluorescencequenchingbetweenthesedonorsubstratesandmono-6-O-p-nitrobenzoyl-β-cyclodextrin(pNBCD)andmono-6-O-m-nitrobenzoyl-β-cyclodextrin(mNBCD)wasstudiedindetail.Itwasfoundthatveryefficientfluorescencequenchingcouldoccurinthesesupramolecularsystems.Thisquenchingwasattributedtothephotoinducedelectrontransferinsidethesupramolecularassemblybetweenthenaphthalenedonorsandcyclodextrinacceptors.DetailedStern-VolmerconstantsweremeasuredandtheywerepartitionedintodynamicStern-Volmerquenchingconstantsandstaticbindingconstants.Itwasdemonstratedthatthebindingconstantsbetweenallthenaphthalenecompoundsandcyclodextrinsarethesameastheypossessthesamebindingsite,i.e.,adamantanamine.

简介：Anovelcovalentlymodifiedglassycarbonelectrodewithβ-cyclodextrinwaspreparedviaelectropolymerizationtechniqueforthesimultaneousdeterminationofuricacid(UA),xanthine(XA),hypoxanthine(HX)anddopamine(DA).ThisnewelectrodepresentedanexcellentelectrocatalyticactivitytowardstheoxidationofUA,XA,HXandDAbycyclicvoltammetry(CV)method.Theoxidationpeaksofthefourcompoundswerewelldefinedandhadtheenhancedpeakcurrents.TheseparationpotentialsoftheoxidationpeaksforDA-UA,UA-XAandXA-HXwere150,390and360mVinCV,respectively.Bymeansofdifferentialpulsevoltammetry(DPV)method,thecalibrationcurvesintherangesof10―225,5―105,10―170and5―150μmol/LwereobtainedforUA,XA,HXandDA,respectively.Thelowestdetectionlimits(S/N=3)were5,1.25,5and1.5μmol/LforUA,XA,HXandDA,respectively.ThepracticalapplicationofthemodifiedelectrodewasdemonstratedbythedeterminationofDAinhydrochlorideinjectionandUA,XA,HXinhumanurinesamples.

简介：Toinvestigatethetreatmenteffectof2-seleniumbridgedβ-cyclodextrin(2-SeCD),aGPXmimic,onthestrokeofstroke-pronespontaneouslyhypertensiverats(SHRSP),fifty-twoSHRSPof8-weekoldwererandomlydividedintofourgroupsA,B,CandcontrolgroupD.TheratsofgroupsA,B,CandDweregiven1.0%-1.5%NaClmassfractionasdrinkingfluid.Afteronsetofstroke,groupsA,BandCweregivenorally16.05,160.5and1605mg*kg-1*day-1of2-SeCD,respectively,andgroupDwasgivenwaterfor2weeks.Theclinicalscoreofstroke,systolicbloodpressure(SBP),survivaltimeofratswererecordedandthehistopathologicexaminationsoftheirbrainandcarotidarteryweremadeafterdecapitation.Theclinicalscoresofstrokeaftertreatmentwith160.5mg*kg-1*day-1(GroupB)and1605mg*kg-1*day-1(GroupC)of2-SeCDare2.55±0.98and1.98±0.79,respectively,thoseareobviouslylowerthanthatofgroupD(3.41±0.83,p<0.01).ThesurvivaldaysingroupB(10.0±8.6)andgroupC(14.4±7.9)arelongerthanthatforgroupD(4.7±2.9,p<0.01).TheelectronmicroscopestudyshowedthattheendotheliumofcarotidarterywasneartonormalingroupBandgroupC,whileitwasseriouslyinjuredincontrolgroupDandmildlyinjuredingroupA.2-SeCDmayeffectivelybeusedtotreatthestrokeforSHRSP.

简介：Theseparationofenantiomersofaseriesofeighteennovelnitrogenmustardlinkedphosphoryldiamidederivativeswasinvestigatedonthepreparedphenylcarbamatederivativeβ-cy-clodextrinbondedphaseinnormal-phaseHPLC.Someoftheenantiomerscouldbeseparatedinbaseline.Thechiralrecognitionmechanismwasalsosuggestedfortheseparationofchiralphosphorusorganiccompounds.

简介：Usingfourβ-cyclodextrinderivatives,2,6-di-O-benzyl-3-O-heptanonyl-β-CD,2,6-di-O-benzyl-3-O-octanonyl-β-CD,2,3-di-O-benzyl-6-O-heptanonyl-β-CD,and2,3-di-O-benzyl-6-O-octanonyl-β-CD,aschiralstationaryphasesofcapillarygaschromatography(CGC),theenantiomersofSharplessepoxideswerewellseparated.Theenantiomerexcessvalues(e.e.%)ofsomechiralSharplessepoxideswerealsodeterminedsuccessfullyusingtheseCDs.