简介:Overthepasttwodecadesconsiderableprogresshasbeenmadeinunderstandingtheototoxiceffectsandmechanismsunderlyingloopdiuretics.Astypicalrepresentativeofloopdiureticsethacrynicacidorfurosemideonlyinducestemporaryhearingloss,butrarelypermanentdeafnessunlessappliedinsevereacuteorchronicrenalfailureorwithotherototoxicdrugs.Loopdiureticinduceuniquepathologicalchangesinthecochleasuchasformationofedematousspacesintheepitheliumofthestriavascularis,whichleadstorapiddecreaseoftheendolymphaticpotentialandeventuallossofthecochlearmicrophonicpotential,summatingpotential,andcompoundactionpotential.LoopdiureticsinterferewithstrialadenylatecyclaseandNat/Kt-ATPaseandinhibittheNa-K-2Clcotransporterinthestriavascularis,howeverrecentreportsindicatethatoneoftheearliesteffectsinvivoistoabolishbloodflowinthevesselssupplyingthelateralwall.Sinceethacrynicaciddoesnotdamagethestriavascularisinvitro,thechangesinNat/Kt-ATPaseandNa-K-2Clseeninvivomaybesecondaryeffectsresultsfromstrialischemiaandanoxia.Recentobservationsshowingthatreninispresentinpericytessurroundingstriaarteriolessuggestthatdiureticsmayinducelocalvasoconstrictionbyreninsecretionandangiotensinformation.Thetightjunctionsintheblood-cochleabarrierpreventtoxicmoleculesandpathogensfromenteringcochlea,butwhendiureticsinduceatransientischemia,thebarrieristemporarilydisruptedallowingtheentryoftoxicchemicalsorpathogens.
简介:Fuelcellsandelectrolysisarepromisingcandidatesforfutureenergyproductionfromrenewableenergysources.Usually,polymerelectrolytefuelcellsystemsrunonhydrogenandair,whilethemostofelectrolysissystemsventoutoxygenasunusedby-product.Replacingairwithpureoxygen,fuelcellelectrochemicalperformance,durabilityandsystemefficiencycanbesignificantlyincreasedwithafurtheroverallsystemsimplificationandincreasedreliability.Thiswork,whichrepresentstheinitialstepforpureH2/O2polymerelectrolytefuelcelloperationinclosed-loopsystems,focusesonperformancevalidationofasinglecelloperatingwithpureH2/O2underdifferentrelativehumidity(RH)levels,reactantsstoichiometryconditionsandtemperature.Asaresultofthisstudy,themostconvenientandappropriateoperativeconditionsforapolymerelectrolytefuelcellstackintegratedinaclosedloopsystemwereselected.
简介:Aswitchableandtunableytterbium-dopedfiberringlaser(YDFL)isreportedanddemonstrated.EmployingaSagnacloopmirrorfabricatedbyan85-cm-longpolarization-maintainingfiber(PMF),theproposedYDFLcanoperatewithstabledual-wavelengthlasingortunablesingle-wavelengthlasingaround1064nm.Bothstabledual-wavelengthlasingandtunablesingle-wavelengthlasingareachievedbyadjustingapolarizationcontrollerintheSagnacloopmirror.Theexperimentalresultsshowthattheoutputoftheproposedfiberlaserwithtwodifferentoperationmodesisratherstableatroomtemperature.
简介:AsoneofthekeyunitsofspaceCCDcamera,thetemperaturerangeandstabilityofCCDcomponentsaffecttheimage’sindexes.Reasonablethermaldesignandrobustthermalcontroldevicesareneeded.Onekindoftemperaturecontrolloopheatpipe(TCLHP)isdesigned,whichhighlymeetsthethermalcontrolrequirementsofCCDcomponents.InordertostudythedynamicbehaviorsofheatandmasstransferofTCLHP,particularlyintheorbitalflightcase,atransientnumericalmodelisdevelopedbyusingthewell-establishedempiricalcorrelationsforflowmodelswithinthreedimensionalthermalmodeling.Thetemperaturecontrolprincipleanddetailsofmathematicalmodelarepresented.Themodelisusedtostudyoperatingstate,flowandheatcharacteristicsbasedupontheanalysesofvariationsoftemperature,pressureandqualityunderdifferentoperatingmodesandexternalheatfluxvariations.TheresultsindicatethatTCLHPcansatisfythethermalcontrolrequirementsofCCDcomponentswell,andalwaysensuregoodtemperaturestabilityanduniformity.Bycomparisonbetweenflightdataandsimulatedresults,itisfoundthatthemodelistobeaccuratetowithin1℃.ThemodelcanbebetterusedforpredictingandunderstandingthetransientperformanceofTCLHP.
简介:
简介:Newmetal-freeorganicdyesensitizerscontainingmono-triphenylamineorbis-triphenylamineastheelectrondonor,athiopheneastheπ-conjugatedsystem,andacyanoacrylicacidmoietyastheelectronacceptorweresynthesized.Theopticalandelectrochemicalpropertiesofthedyeswereinvestigated,andtheirperformanceassensitizersinsolarcellswasevaluated.Dye-sensitizedsolarcellsbasedondyecontainingbis-triphenylamineastheelectrondonorproducedaphoton-to-currentconversionefficiencyof6.06%(Jsc=14.21mA/cm~2,Voc=0.62V,ff=0.69)under100mW/cm~2simulatedAM1.5Gsolarirradiation(100mW/cm~2).
简介:Anovelmagneticfieldsensingsystembasedonthefiberloopring-downtechniqueisproposedinthispaper.Inthefiberloop,aU-bentsingle-mode-fiberstructurecoatedwithmagneticfluid(MF)servesasthesensinghead,andanerbium-dopedfiberamplifier(EDFA)isintroducedtocompensatefortheintrinsiclossofthecavity.Thering-downtimeofthesystemvarieswiththechangeofappliedmagneticfieldduetothetunableabsorptioncoefficientandrefractiveindexoftheMF.Therefore,measurementofthemagneticfieldcanberealizedbymonitoringtheringdowntime.Theexperimentalresultsshowthattheperformanceofthesystemisextremelydependentontheinterrogationwavelength,becauseboththegainoftheEDFAandthelossofthesensingheadarewavelengthdependent.Wefoundthatattheoptimalwavelength,theratioofthegaintolossattaineditsmaximum.Thesensingsystemwasexperimentallydemonstratedandasensitivityof-0.5951μs∕Oewasachieved.
简介:Tosolvetheflightsafetyproblemcausedbynonlinearinstabilities(categoryIIpilotinducedoscillations,PIOs)oftheclosed-looppilot-vehiclesystemwithrate-limitingactuator,theantiwindup(AW)compensationmethodtoavoidcategoryIIPIOsisinvestigated.Firstly,theAWcompensationmethodoriginallyusedforcontrollinginputmagnitudelimitedsystemisintroduced,thenthismethodisextendedforcontrollinginputrate-limitingsystemthroughacirclecriteriontheorem.Secondly,theestablishmentoftheAWcompensatoristransformedintothesolvingoflinearmatrixinequalities.Finally,anAWcompensatorestablishmentalgorithmfortheclosed-looppilot-vehiclesystemwiththerate-limitingactuatorisobtained.TheeffectivenessoftheAWcompensationmethodtoavoidcategoryIIPIOsisvalidatedbytime-domainsimulations,andcomparedwithrate-limitedfeedback(RLF)commandratecompensationmethod.TheresultsshowthattheAWcompensationmethodcaneffectivelysuppresscategoryIIPIOsandmaintainthenominalperformancewhentheclosed-looppilot-vehiclesystemisnormal.Unlikethecommandratecompensatorwhichworksuponsystemuninterruptedly,theAWcompensationmethodaffectstheclosed-looppilot-vehiclesystemonlywhentherate-limitingofactuatorisactivated,soitisanovelPIOavoidancemethod.